Results 31 to 40 of about 7,863,983 (293)

Defense Priming in Nicotiana tabacum Accelerates and Amplifies ‘New’ C/N Fluxes in Key Amino Acid Biosynthetic Pathways

Plants, 2020
In the struggle to survive herbivory by leaf-feeding insects, plants employ multiple strategies to defend themselves. One mechanism by which plants increase resistance is by intensifying their responsiveness in the production of certain defense agents to
Nils Hanik, Marcel Best, Michael J. Schueller, Ryan Tappero, Richard A. Ferrieri   +4 more
doaj   +1 more source

Pitfalls and solutions of the fully-automated radiosynthesis of [11C]metoclopramide

EJNMMI Radiopharmacy and Chemistry, 2019
Background [11C]Metoclopramide is a new radiotracer for investigating the activity of P-glycoprotein at the blood-brain barrier. A highly stable and reproducible radiosynthesis is a prerequisite for clinical studies applying [11C]metoclopramide or other ...
Verena Pichler, Marius Ozenil, Karsten Bamminger, Chrysoula Vraka, Marcus Hacker, Oliver Langer, Wolfgang Wadsak   +6 more
doaj   +1 more source

Non-invasive 11C-Imaging Revealed the Spatiotemporal Variability in the Translocation of Photosynthates Into Strawberry Fruits in Response to Increasing Daylight Integrals at Leaf Surface

Frontiers in Plant Science, 2021
The efficiency of photosynthate translocation from leaves to fruits directly affects dry matter partitioning. Therefore, controlling photosynthate translocation dynamics is critical for high-yield and high-quality fruit production.
Yuta Miyoshi, Kota Hidaka, Yong-Gen Yin, Nobuo Suzui, Keisuke Kurita, Keisuke Kurita, Naoki Kawachi   +6 more
doaj   +1 more source

Quantifying Plant-Borne Carbon Assimilation by Root-Associating Bacteria

Microorganisms, 2020
Herbaspirillum seropedicae is a rhizobacteria that occupies a specialized ecological niche in agriculture. As an endophyte and prolific grass root colonizer it has the potential to promote plant growth, enhancing crop yield in many cereal crops.
Spenser Waller, Stacy L. Wilder, Michael J. Schueller, Alexandra B. Housh, Richard A. Ferrieri   +4 more
doaj   +1 more source

From Carbon-11-Labeled Amino Acids to Peptides in Positron Emission Tomography: the Synthesis and Clinical Application

Molecular Imaging and Biology, 2018
Radiolabeled amino acids, their derivatives and peptides have a broad scope of application and can be used as receptor ligands, as well as enzyme substrates for many different diseases as radiopharmaceutical tracers.
A. Pekošak, U. Filp, A. Poot, A. Windhorst   +3 more
semanticscholar   +1 more source

Synthesis and Evaluation of ¹¹C-Labeled Triazolones as Probes for Imaging Fatty Acid Synthase Expression by Positron Emission Tomography

Molecules, 2022
Cancer cells require lipids to fulfill energetic, proliferative, and signaling requirements. Even though these cells can take up exogenous fatty acids, the majority exhibit a dependency on de novo fatty acid synthesis.
James M. Kelly, Thomas M. Jeitner, Nicole N. Waterhouse, Wenchao Qu, Ethan J. Linstad, Banafshe Samani, Clarence Williams, Anastasia Nikolopoulou, Alejandro Amor-Coarasa, Stephen G. DiMagno, John W. Babich   +10 more
doaj   +1 more source

Carbon-11 carboxylation of trialkoxysilane and trimethylsilane derivatives using [11C]CO2

Chemical Communications, 2019
A simple and rapid carbon-11 carboxylation radiosynthesis method.
S. Bongarzone, Nicola Raucci, I. Fontana, Federico Luzi, A. Gee   +4 more
semanticscholar   +1 more source

Rapid one-pot radiosynthesis of [carbonyl-11C]formamides from primary amines and [11C]CO2

EJNMMI Radiopharmacy and Chemistry, 2020
Background Formamides are common motifs of biologically-active compounds (e.g. formylated peptides) and are frequently employed as intermediates to yield a number of other functional groups.
Federico Luzi, Antony D. Gee, Salvatore Bongarzone   +2 more
doaj   +1 more source

Radiolabeled COX-2 Inhibitors for Non-Invasive Visualization of COX-2 Expression and Activity — A Critical Update

Molecules, 2013
Cyclooxygenase-2 (COX-2) is a key player in inflammation. Its overexpression is directly associated with various inflammatory diseases and, additionally, with several processes of carcinogenesis. The development of new selective COX-2 inhibitors (COXIBs)
Torsten Kniess, Markus Laube, Jens Pietzsch   +2 more
doaj   +1 more source

PET Molecular Imaging in Drug Development: The Imaging and Chemistry Perspective

Frontiers in Medicine, 2022
Positron emission tomography with selective radioligands advances the drug discovery and development process by revealing information about target engagement, proof of mechanism, pharmacokinetic and pharmacodynamic profiles. Positron emission tomography (
Sridhar Goud Nerella, Priti Singh, Tulja Sanam, Chander Singh Digwal   +3 more
doaj   +1 more source