Results 21 to 30 of about 997,598 (214)

Pitfalls and solutions of the fully-automated radiosynthesis of [11C]metoclopramide

EJNMMI Radiopharmacy and Chemistry, 2019
Background [11C]Metoclopramide is a new radiotracer for investigating the activity of P-glycoprotein at the blood-brain barrier. A highly stable and reproducible radiosynthesis is a prerequisite for clinical studies applying [11C]metoclopramide or other ...
Verena Pichler, Marius Ozenil, Karsten Bamminger, Chrysoula Vraka, Marcus Hacker, Oliver Langer, Wolfgang Wadsak   +6 more
doaj   +1 more source

Quantifying Plant-Borne Carbon Assimilation by Root-Associating Bacteria

Microorganisms, 2020
Herbaspirillum seropedicae is a rhizobacteria that occupies a specialized ecological niche in agriculture. As an endophyte and prolific grass root colonizer it has the potential to promote plant growth, enhancing crop yield in many cereal crops.
Spenser Waller, Stacy L. Wilder, Michael J. Schueller, Alexandra B. Housh, Richard A. Ferrieri   +4 more
doaj   +1 more source

Synthesis and Evaluation of ¹¹C-Labeled Triazolones as Probes for Imaging Fatty Acid Synthase Expression by Positron Emission Tomography

Molecules, 2022
Cancer cells require lipids to fulfill energetic, proliferative, and signaling requirements. Even though these cells can take up exogenous fatty acids, the majority exhibit a dependency on de novo fatty acid synthesis.
James M. Kelly, Thomas M. Jeitner, Nicole N. Waterhouse, Wenchao Qu, Ethan J. Linstad, Banafshe Samani, Clarence Williams, Anastasia Nikolopoulou, Alejandro Amor-Coarasa, Stephen G. DiMagno, John W. Babich   +10 more
doaj   +1 more source

Rapid one-pot radiosynthesis of [carbonyl-11C]formamides from primary amines and [11C]CO2

EJNMMI Radiopharmacy and Chemistry, 2020
Background Formamides are common motifs of biologically-active compounds (e.g. formylated peptides) and are frequently employed as intermediates to yield a number of other functional groups.
Federico Luzi, Antony D. Gee, Salvatore Bongarzone   +2 more
doaj   +1 more source

PET Molecular Imaging in Drug Development: The Imaging and Chemistry Perspective

Frontiers in Medicine, 2022
Positron emission tomography with selective radioligands advances the drug discovery and development process by revealing information about target engagement, proof of mechanism, pharmacokinetic and pharmacodynamic profiles. Positron emission tomography (
Sridhar Goud Nerella, Priti Singh, Tulja Sanam, Chander Singh Digwal   +3 more
doaj   +1 more source

Radiolabeled COX-2 Inhibitors for Non-Invasive Visualization of COX-2 Expression and Activity — A Critical Update

Molecules, 2013
Cyclooxygenase-2 (COX-2) is a key player in inflammation. Its overexpression is directly associated with various inflammatory diseases and, additionally, with several processes of carcinogenesis. The development of new selective COX-2 inhibitors (COXIBs)
Torsten Kniess, Markus Laube, Jens Pietzsch   +2 more
doaj   +1 more source

A Facile Fabrication of Ordered Mesoporous Carbons Derived from Phenolic Resin and Mesophase Pitch via a Self-Assembly Method

Nanomaterials, 2022
Ordered and disordered mesoporous structures were synthesized by a self-assembly method using a mixture of phenolic resin and petroleum-based mesophase pitch as the starting materials, amphiphilic triblock copolymer F127 as a soft template, hydrochloric ...
Jae-Yeon Yang, Tae Hoon Ko, Yun-Su Kuk, Min-Kang Seo, Byoung-Suhk Kim   +4 more
doaj   +1 more source

Cross-Coupling Reactions as Valuable Tool for the Preparation of PET Radiotracers

Molecules, 2011
The increasing application of positron emission tomography (PET) in nuclear medicine has stimulated the extensive development of a multitude of new radiotracers and novel radiolabeling procedures with the most prominent short-lived positron emitters ...
Marc Pretze, Constantin Mamat, Philipp Große-Gehling   +2 more
doaj   +1 more source

Huntington’s Disease: A Review of the Known PET Imaging Biomarkers and Targeting Radiotracers

Molecules, 2020
Huntington’s disease (HD) is a fatal neurodegenerative disease caused by a CAG expansion mutation in the huntingtin gene. As a result, intranuclear inclusions of mutant huntingtin protein are formed, which damage striatal medium spiny neurons (MSNs)
Klaudia Cybulska, Lars Perk, Jan Booij, Peter Laverman, Mark Rijpkema   +4 more
doaj   +1 more source

Determination of the Electrical Parameters of Iodine-Doped Polymer Solar Cells at the Macro- and Nanoscale for Indoor Applications

Energies, 2023
In this work, macro- and nanodiagnostic procedures for working, third-generation photovoltaic devices based on a modified polymer:fullerene (P3HT:PCBM) absorber were conducted using atomic force microscopy (AFM) and impedance spectroscopy (IS) equipment.
Marcin Palewicz, Andrzej Sikora, Tomasz Piasecki, Ewelina Gacka, Paweł Nitschke, Paweł Gnida, Bożena Jarząbek, Teodor Gotszalk   +7 more
doaj   +1 more source