Results 21 to 30 of about 7,863,983 (293)

On the Road towards Small-Molecule Programmed Cell Death 1 Ligand 1 Positron Emission Tomography Tracers: A Ligand-Based Drug Design Approach

Pharmaceuticals, 2023
PD-1/PD-L1 immune checkpoint blockade for cancer therapy showed promising results in clinical studies. Further endeavors are required to enhance patient stratification, as, at present, only a small portion of patients with PD-L1-positive tumors (as ...
Karsten Bamminger, Verena Pichler, Chrysoula Vraka, Tina Nehring, Katharina Pallitsch, Barbara Lieder, Marcus Hacker, Wolfgang Wadsak   +7 more
doaj   +1 more source

A Study On The Metal Carbide Composite Diffusion Bonding For Mechanical Seal

Archives of Metallurgy and Materials, 2015
Mechanical Seal use highly efficient alternative water having a great quantity of an aqueous solution and has an advantage no corrosion brine. Metal Carbide composites have been investigated as potential materials for high temperature structural ...
Kim D.-K., Shon I.-J., Song J., Ryu W.-J., Shin H.-Ch., Kwon E.-Y., Shin H., Kang S.-J.   +7 more
doaj   +1 more source

Cu-Expanded Graphite Composite Material Preparation and Thermal Properties

Eurasian Chemico-Technological Journal, 2017
A composite material based on expanded graphite (EG) and copper compounds was obtained by natural graphite oxidation with 95% nitric acid, copper (II) nitrate and granular carbamide addition with further rapid heat treatment at three different ...
I. M. Karzov, O. N. Shornikova, S. V. Filimonov, A. P. Malakho, V. V. Avdeev   +4 more
doaj   +1 more source

Recent Advances in the Development and Application of Radiolabeled Kinase Inhibitors for PET Imaging

Molecules, 2015
Over the last 20 years, intensive investigation and multiple clinical successes targeting protein kinases, mostly for cancer treatment, have identified small molecule kinase inhibitors as a prominent therapeutic class.
Vadim Bernard-Gauthier, Justin J. Bailey, Sheldon Berke, Ralf Schirrmacher   +3 more
doaj   +1 more source

Boron Nitride Nanotube Cyclotron Targets for Recoil Escape Production of Carbon-11

Instruments, 2019
Boron nitride nanotubes (BNNTs) were investigated as a target media for cyclotron production of 11C for incident beam energy at or below 11 MeV. Both the 11B(p,n)11C and 14N(p,α)11C nuclear reactions were utilized.
Johanna Peeples, Sang-Hyon Chu, James P. O’Neil, Mustafa Janabi, Bruce Wieland, Matthew Stokely   +5 more
doaj   +1 more source

E-Cigarette Aerosol Deposition and Disposition of [¹¹C]Nicotine Using Positron Emission Tomography: A Comparison of Nicotine Uptake in Lungs and Brain Using Two Different Nicotine Formulations

Pharmaceuticals, 2022
Smoking is a cause of serious disease in smokers. Electronic cigarettes, delivering aerosolized nicotine, offer adult smokers a potentially less harmful alternative to combustible cigarettes.
Anders Wall, Sara Roslin, Beatrice Borg, Simon McDermott, Tanvir Walele, Thomas Nahde, Grant O’Connell, Joseph Thompson, Mark Lubberink, Gunnar Antoni   +9 more
doaj   +1 more source

Radiosynthesis and First Preclinical Evaluation of the Novel 11C-Labeled FAP Inhibitor 11C-FAPI: A Comparative Study of 11C-FAPIs and (68Ga) Ga-DOTA-FAPI-04 in a High–FAP-Expression Mouse Model

Frontiers in Chemistry, 2022
Purpose: 68Ga-labeled fibroblast activation protein inhibitors, such as [68Ga]Ga-DOTA-FAPI-04 and [68Ga]Ga-DOTA-FAPI-46, have been successfully applied in positron emission tomography imaging of various tumor types.
Cheng Wang, Zhoumi Hu, Fan Ding, Haitao Zhao, Fuqiang Du, Chun Lv, Lianghua Li, Gang Huang, Gang Huang, Jianjun Liu   +9 more
doaj   +1 more source

Preliminary Evaluations of [11C]Verubulin: Implications for Microtubule Imaging With PET

Frontiers in Neuroscience, 2021
[11C]Verubulin (a.k.a.[11C]MCP-6827), [11C]HD-800 and [11C]colchicine have been developed for imaging microtubules (MTs) with positron emission tomography (PET).
Anton Lindberg, Andrew V. Mossine, Arturo Aliaga, Robert Hopewell, Gassan Massarweh, Pedro Rosa-Neto, Xia Shao, Vadim Bernard-Gauthier, Vadim Bernard-Gauthier, Vadim Bernard-Gauthier, Peter J. H. Scott, Neil Vasdev, Neil Vasdev, Neil Vasdev   +13 more
doaj   +1 more source

Practical Radiosynthesis and Preclinical Neuroimaging of [11C]isradipine, a Calcium Channel Antagonist

Molecules, 2015
In the interest of developing in vivo positron emission tomography (PET) probes for neuroimaging of calcium channels, we have prepared a carbon-11 isotopologue of a dihydropyridine Ca2+-channel antagonist, isradipine. Desmethyl isradipine (4-(benzo[c][1,
Benjamin H. Rotstein, Steven H. Liang, Vasily V. Belov, Eli Livni, Dylan B. Levine, Ali A. Bonab, Mikhail I. Papisov, Roy H. Perlis, Neil Vasdev   +8 more
doaj   +1 more source

Adventures with Carbons 11, 12, 13 and 14 [PDF]

Photosynthesis Research, 2011
I provide here a glimpse of my involvement with different isotopes of carbon. In my 65 years of synthetic work with C-12, I had experience working with C-11 (one year, 1942-1943), C-13 (one year, 1999) and C-14 (67 years, 1943-2009). I have also included a postscript dealing with my 1951 communication on the 5-carbon intermediate in photosynthesis.
openaire   +2 more sources