Results 1 to 10 of about 7,863,834 (154)

Carbon-11 and Fluorine-18 Labeled Amino Acid Tracers for Positron Emission Tomography Imaging of Tumors [PDF]

Frontiers in Chemistry, 2018
Tumor cells have an increased nutritional demand for amino acids (AAs) to satisfy their rapid proliferation. Positron-emitting nuclide labeled AAs are interesting probes and are of great importance for imaging tumors using positron emission tomography ...
Aixia Sun, Xiang Liu, Ganghua Tang
doaj   +3 more sources

Recent Developments in Carbon-11 Chemistry and Applications for First-In-Human PET Studies. [PDF]

Molecules, 2023
Positron emission tomography (PET) is a molecular imaging technique that makes use of radiolabelled molecules for in vivo evaluation. Carbon-11 is a frequently used radionuclide for the labelling of small molecule PET tracers and can be incorporated into
Pees A, Chassé M, Lindberg A, Vasdev N.
europepmc   +2 more sources

Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds. [PDF]

Chem Rev, 2023
The presence of positron emission tomography (PET) centers at most major hospitals worldwide, along with the improvement of PET scanner sensitivity and the introduction of total body PET systems, has increased the interest in the PET tracer development ...
Shegani A, Kealey S, Luzi F, Basagni F, Machado JDM, Ekici SD, Ferocino A, Gee AD, Bongarzone S.   +8 more
europepmc   +2 more sources

Discovery of carbon-11 labeled sulfonamide derivative: A PET tracer for imaging brain NLRP3 inflammasome. [PDF]

Bioorg Med Chem Lett, 2021
We report herein the discovery of a positron emission tomography (PET) tracer for the (NOD)-like receptor protein 3 (NLRP3). Our recent medicinal chemistry campaign on developing sulfonamide-based NLRP3 inhibitors led to an analog, 1, with a methoxy ...
Xu Y, Xu Y, Blevins H, Lan Y, Liu Y, Yuan G, Striar R, Zagaroli JS, Tocci DR, Langan AG, Zhang C, Zhang S, Wang C.   +12 more
europepmc   +2 more sources

Technical Design Report for a Carbon-11 Treatment Facility [PDF]

Frontiers in Medicine, 2022
Particle therapy relies on the advantageous dose deposition which permits to highly conform the dose to the target and better spare the surrounding healthy tissues and organs at risk with respect to conventional radiotherapy.
Liviu Penescu, Thierry Stora, Simon Stegemann, Johanna Pitters, Elisa Fiorina, Elisa Fiorina, Ricardo Dos Santos Augusto, Ricardo Dos Santos Augusto, Ricardo Dos Santos Augusto, Claus Schmitzer, Fredrik Wenander, Katia Parodi, Alfredo Ferrari, Thomas E. Cocolios   +13 more
doaj   +2 more sources

Carbon-11 Radiotracing Reveals Physiological and Metabolic Responses of Maize Grown under Different Regimes of Boron Treatment [PDF]

Plants, 2022
In agriculture, boron is known to play a critical role in healthy plant growth. To dissect the role of boron in maize metabolism, radioactive carbon-11 (t½ 20.4 min) was used to examine the physiological and metabolic responses of 3-week-old B73 maize ...
Stacy L. Wilder, Stephanie Scott, Spenser Waller, Avery Powell, Mary Benoit, James M. Guthrie, Michael J. Schueller, Prameela Awale, Paula McSteen, Michaela S. Matthes, Richard A. Ferrieri   +10 more
doaj   +2 more sources

Reactive Palladium–Ligand Complexes for ¹¹C-Carbonylation at Ambient Pressure: A Breakthrough in Carbon-11 Chemistry [PDF]

Pharmaceuticals, 2023
The Pd–Xantphos-mediated 11C-carbonylation protocol (also known as the “Xantphos- method”), due to its simplistic and convenient nature, has facilitated researchers in meeting a longstanding need for preparing 11C-carbonyl-labeled radiopharmaceuticals at
Kenneth Dahl, Anton Lindberg, Neil Vasdev, Magnus Schou   +3 more
doaj   +2 more sources

Gas Phase Transformations in Carbon-11 Chemistry. [PDF]

Int J Mol Sci
The short-lived positron-emitter carbon-11 (t1/2 = 20.4 min; β+, 99.8%) is prominent for labeling tracers for use in biomedical research with positron emission tomography (PET).
Lu S, Telu S, Siméon FG, Cai L, Pike VW.   +4 more
europepmc   +2 more sources

New methodologies for the preparation of carbon-11 labeled radiopharmaceuticals. [PDF]

Clin Transl Imaging, 2017
PurposeThis short review aims to cover the more recent and promising developments of carbon-11 (11C) labeling radiochemistry and its utility in the production of novel radiopharmaceuticals, with special emphasis on methods that have the greatest ...
Dahl K, Halldin C, Schou M.
europepmc   +2 more sources

Ethanolic carbon-11 chemistry: the introduction of green radiochemistry. [PDF]

Appl Radiat Isot, 2014
The principles of green chemistry have been applied to a radiochemistry setting. Eleven carbon-11 labeled radiopharmaceuticals have been prepared using ethanol as the only organic solvent throughout the entire manufacturing process.
Shao X, Fawaz MV, Jang K, Scott PJ.
europepmc   +2 more sources