Results 91 to 100 of about 11,218 (183)
The Multifaceted Legacy of Thalidomide: Chemistry and Biology Driving Modern Drug Design
ChemMedChem, Volume 21, Issue 7, 14 April 2026.Thalidomide serves as a molecular nexus linking chemistry and biology: advances in synthesis and structural understanding enable protein degradation technologies, while its immunomodulatory activity underpins anti‐inflammatory and anticancer therapies.
Konstantina Nikovia +4 more
wiley +1 more source
Transcriptional Response to Acute Thermal Exposure in Juvenile Chinook Salmon Determined by RNAseq. [PDF]
, 2015 Thermal exposure is a serious and growing challenge facing fish species worldwide. Chinook salmon (Oncorhynchus tshawytscha) living in the southern portion of their native range are particularly likely to encounter warmer water due to a confluence of ...
Baerwald, Melinda R +6 more
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Advanced Science, Volume 13, Issue 19, 2 April 2026.Staphylococcus aureus (S. aureus) infection creates a high‐lactate microenvironment, promoting p300‐mediated lactylation of PGK1 at lysine 361 (K361). Lactylated PGK1 translocates to the mitochondrial outer membrane and interacts with VDAC3. This interaction triggers FtMt downregulation, iron accumulation, and excessive PINK1/Parkin‐mediated mitophagy,
Han‐jun Qin +5 more
wiley +1 more source
Regulation of Protein Degradation in the Heart by AMP-Activated Protein Kinase [PDF]
, 2012 The degradation of proteins by the ubiquitin proteasome system is essential for cellular homeostasis in the heart. An important regulator of metabolic homeostasis is AMP-activated protein kinase (AMPK).
Baskin, Kedryn K, Baskin, Kedryn K
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MedComm, Volume 7, Issue 4, April 2026.This graphical abstract shows the antibacterial potential of phytochemicals from 15 spices, showcasing key compounds, their extraction methods, and mechanisms of action. It highlights membrane disruption, ROS generation, enzyme inhibition, and biofilm prevention as core antibacterial pathways.
Hettiyahandi Binodh De Silva +3 more
wiley +1 more source
Transcriptional activation and intracellular localization of Arabidopsis ubiquitin ligase ATL31 in defense and carbon/nitrogen response [an abstract of entire text]]この博士論文全文の閲覧方法については、以下のサイトをご参照ください。 https://www.lib.hokudai.ac.jp/dissertations/copy-guides/ (主査) 教授 山口 淳二, 准教授 藤田 知道, 准教授 千葉 由佳子, 助教 佐藤 長緒 生命科学院（生命科学専攻）
openaire
Isolation, genome sequencing, assembly, annotation and Characterization of Thermus sp. CCB_US3_UF1 FROM Ulu Slim, Perak, Malaysia. [PDF]
, 2011 Thermus sp. CCB_US3_UF1, satu bacteria thermofilik telah Berjaya dipencilkan dari kolam air panas di Ulu Slim, Perak, Malaysia. Genomnya mengandungi 2,243,772 pasangan bes dan satu plasmid bersaiz 19,716 pasangan bes. Thermus sp.
Teh, Beng Soon
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ApoJ regulates endothelial lipase activity and stability
Protein Science, Volume 35, Issue 4, April 2026.Abstract Endothelial lipase (EL) is a key regulator of high‐density lipoprotein (HDL) metabolism. Many aspects of EL function remain incompletely understood due to challenges in purifying active EL. This study identifies apolipoprotein J (ApoJ) as a novel chaperone for EL, crucial for its solubility and activity.
Uriel L. Jean‐Baptiste +5 more
wiley +1 more source
Dynamic nature of proteins : interpretation of residual dipolar couplings [PDF]
, 2007 Protein conformations and dynamics can be studied by nuclear magnetic resonance spectroscopy using dilute liquid crystalline samples. This work clarifies the interpretation of residual dipolar coupling data yielded by the experiments.
Louhivuori, Martti
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Neuroprotective Effects of Cerium Oxide Nanoparticles During Spaceflight
Small Science, Volume 6, Issue 4, April 2026.Cerium oxide nanoparticles are investigated as antioxidant neuroprotectants for neurons exposed to the spaceflight environment aboard the International Space Station. The treatment preserves neuronal morphology, supports neurite outgrowth, and stabilizes gene networks involved in antioxidant defense, mitochondrial function, and dopamine metabolism ...
Alessio Carmignani +13 more
wiley +1 more source