Results 31 to 40 of about 11,301 (193)

Functional role of PGAM5 multimeric assemblies and their polymerization into filaments. [PDF]

, 2019
PGAM5 is a mitochondrial protein phosphatase whose genetic ablation in mice results in mitochondria-related disorders, including neurodegeneration. Functions of PGAM5 include regulation of mitophagy, cell death, metabolism and aging.
Agnew, Christopher, Frost, Adam, Herrera, Clara, Ingaramo, Maria, Jura, Natalia, Miller-Vedam, Lakshmi, Ruiz, Karen, Thaker, Tarjani M, Toso, Daniel, Trenker, Raphael   +9 more
core   +3 more sources

Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions

Advanced Science, EarlyView.
This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang, Wenzhi Wang, Dongjiao Wang, Qibin Wu, Youxiong Que   +4 more
wiley   +1 more source

Novel European free-living, non-diazotrophic Bradyrhizobium isolates from contrasting soils that lack nodulation and nitrogen fixation genes - a genome comparison [PDF]

, 2016
The slow-growing genus Bradyrhizobium is biologically important in soils, with different representatives found to perform a range of biochemical functions including photosynthesis, induction of root nodules and symbiotic nitrogen fixation and ...
A Bejarano, A Peix, B Gourion, BL Horecker, BS Weir, C Bobik, D Richardson, D Vaninsberghe, E Fullam, E Giraud, E Meilhoc, EJ Bedmar, HL Xi, IA Suvorova, J Gregor, J Preston-Mafham, JL Sachs, K Zhalnina, L Ferrieres, LA Fernandez, LK Black, M Kanehisa, M Kanehisa, M Neumann, M Schmid, M Zuber, MJ Delgado, MS Roset, N Igarashi, NF Alikhan, P Dimroth, P Menna, P Menna, P Van Berkum, P Van Berkum, P Van Rhijn, PL Li, PR Hirsch, R Luo, R Overbeek, R Rivas, RC Edgar, RK Aziz, RS Kaas, S Henry, S Uroz, T Kaneko, T Kaneko, T Okubo, T Okubo, TH Mauchline, TO Delmont, Y Kawaharada, Y Shiina, Y Wang, YS Kim, YS Kim   +56 more
core   +2 more sources

Liquid Metal Nanotransformers for Drug‐Resistant Pan‐Cancer Therapy in Patient‐Derived Organoids

Advanced Science, EarlyView.
Pan‐cancer therapies are severely limited in drug‐resistance patients due to genetic mutations and other factors, resulting in poor therapeutic outcomes and constrained clinical benefit. Liquid metal nanotransformers, a new class of shape‐transformable nanomaterials capable of dramatic morphological changes, offer a promising physical strategy to ...
Xiaojie Yuan, Xuelin Wang, Zhongyao Chen, Shuo Wang, Weining Gao, Ziyi Chen, Runyang Li, Cheng Hao, Lei Zhang, Qiongqiong Zhang, Ke Zhang, Mei Yu, Qian Liu, Jingxuan Wang, Huiping Li, Simpkins Fiona, Jing Liu, Qiang Liu, Peng Liu, Yawei Hu   +19 more
wiley   +1 more source

RNAseq analysis of Aspergillus fumigatus in blood reveals a just wait and see resting stage behavior [PDF]

, 2015
Background: Invasive aspergillosis is started after germination of Aspergillus fumigatus conidia that are inhaled by susceptible individuals. Fungal hyphae can grow in the lung through the epithelial tissue and disseminate hematogenously to invade into
Ana Conesa, Christoph Sasse, Gerhard H. Braus, Henriette Irmer, Jürgen Loeffler, Patrick Olbermann, Sonia Tarazona, Sven Krappmann   +7 more
core   +6 more sources

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Cars2‐Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2

Advanced Science, EarlyView.
We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng, Hongyong Song, Yin Long, Kaimin Wu, Yinkun Fu, Wenkai Zhou, Wenyan Li, Zhe Shi, Xu‐Yun Zhao   +8 more
wiley   +1 more source

Detailed characterization of a long-term rodent model of critical illness and recovery [PDF]

, 2015
Objective: To characterize a long-term model of recovery from critical illness, with particular emphasis on cardiorespiratory, metabolic, and muscle function. Design: Randomized controlled animal study. Setting: University research laboratory.
Brett, SI, Castells, J, Chambers, D, Ellis, MJ, Freysennet, DG, Hill, NE, Morel, J, Murphy, KG, Phadke, R, Saeed, S, Singer, M, Wilson, DR   +11 more
core   +1 more source

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

Genomic and phenomic screens for flower related RING type ubiquitin E3 ligases in Arabidopsis [PDF]

, 2017
Flowering time control integrates endogenous as well as environmental signals to promote flower development. The pathways and molecular networks involved are complex and integrate many modes of signal transduction.
Bilicka, Marcelina Marta, Chovanček, Erik, Himanen, Kristiina Irma Helena, Mouhu, Katriina, Pavicic, Mirko, Wang, Feng   +5 more
core   +1 more source