Results 61 to 70 of about 11,218 (183)

Tetraspanin‐ESCRT sorting drives miR‐29b packaging into extracellular vesicles to reverse fibrosis in intrauterine adhesions

BMEMat, EarlyView.
MiR‐29b is enriched in extracellular vesicles (EVs) via a tetraspanin transporter‐dependent endocytosis and sorting complex required for the endosomal transport (ESCRT)‐dependent pathway. These EVs target the 3′ untranslated region (3′UTR) of TGFB2, thereby inhibiting the TGF‐β/Smad3 signaling pathway and repairing endometrial damage in intrauterine ...
Lihao Chen, Jianfeng Wu, Shunhan Zhang, Siqi Huang, Yingjun Xie, Hongda Chen, Yinghong Yang, Lan Xiao, Ding Wang, Keke Wu, Xiaofang Sun   +10 more
wiley   +1 more source

Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers

Chemistry – A European Journal, EarlyView.
ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda, Alan Pham, SreeNidhi Karnati, Natalia Soto Rodriguez, Alyssa Toner, Wenshe Ray Liu   +5 more
wiley   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Meiotic control of the APC/C: similarities & differences from mitosis [PDF]

, 2011
The anaphase promoting complex is a highly conserved E3 ligase complex that mediates the destruction of key regulatory proteins during both mitotic and meiotic divisions.
Katrina F Cooper, Randy Strich
core   +2 more sources

Comparative Analysis of Heat Exposure‐Induced Molecular Changes in Two Turtle Species with Contrasting Thermal Adaptations

Integrative Zoology, EarlyView.
Protein processing in the endoplasmic reticulum is highlighted in response to heat stress in Platysternon megacephalum. Under heat stress, the up‐regulation of genes such as CHOP in protein processing in the endoplasmic reticulum pathway, along with the suppression of energy and lipid metabolism and the up‐regulation of JARID2 expression, leads to ...
Jian Hong, Yangchun Gao, Jiaxuan Li, Yan Ge, Yufeng Wei, Youqiang Yin, Qianru Liang, Shiping Gong   +7 more
wiley   +1 more source

Structural insight into SUMO chain recognition and manipulation by the ubiquitin ligase RNF4 [PDF]

, 2014
The small ubiquitin-like modifier (SUMO) can form polymeric chains that are important signals in cellular processes such as meiosis, genome maintenance and stress response.
A Hershko, A Plechanovova, A Plechanovova, A Rojas-Fernandez, AM Weissman, AT Brunger, AT Namanja, CC Chang, CH Cheng, CM Hecker, CM Pickart, CW Liew, D Reverter, E Escobar-Cabrera, ES Johnson, F Ikeda, FM Lin, GNB Yip, H Sun, HD Ulrich, HY Sun, I Matic, J Marchant, J Prudden, J Song, J Song, J Xia, JD Schnell, JH Hurley, JL Battiste, JS Thrower, K Keusekotten, L Deng, M Ottiger, M Zweckstetter, MH Tatham, MH Tatham, MJ Eddins, MJ Eddins, MR Hansen, MS Rodriguez, N Sekiyama, N Zhang, O Kerscher, O Kerscher, Q Wang, R Bruderer, R Lescasse, R Mahajan, R Varadan, RT Hay, S-R Tzeng, SC Panchal, W Rieping, W-C Huang, XD Zhang, Y Shen, Y Xie   +57 more
core   +4 more sources

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

The FEBS Journal, EarlyView.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova, Angelina Osipyan, Lili Zhang, Matthew R. Groves, Sandy Schmidt, Kristina Haslinger   +5 more
wiley   +1 more source

Comparative biochemistry of CO2 fixation and the evolution of autotrophy [PDF]

, 1999
Carbon dioxide fixation is a polyphyletic trait that has evolved in widely separated prokaryotic branches. The three principal CO2-assimilation pathways are (i) the reductive pentose-phosphate cycle, i. e.
Becerra, Arturo, Lezcano, Antonio, Peretó, Juli, Velasco, Ana Maria   +3 more
core  

H2‐dependent modulation of tetrahydromethanopterin S‐methyltransferase (Mtr complex) activity by the small protein MtrR in Methanosarcina mazei

The FEBS Journal, EarlyView.
Small protein MtrR is a regulator of the Mtr methyltransferase complex in Methanosarcina mazei. It binds specifically to the MtrA subunit and modulates Mtr activity in response to hydrogen (H2) availability. Deleting mtrR impairs growth in the presence but not absence of H2, indicating its role in directing methyl transfer toward an energy‐conserving ...
Tim Habenicht, Bjarne Hastedt, Liam Cassidy, Claudia Kießling, Andreas Tholey, Jan M. Schuller, Ruth A. Schmitz   +6 more
wiley   +1 more source