Results 61 to 70 of about 5,307,624 (304)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Estimación no paramétrica de la densidad y de la regresión - previsión no paramétrica

open access: yesRevista de Matemática: Teoría y Aplicaciones, 2009
We begin with a short wiew of non parametric estimation of density and regression; then we give details and interpretation of a forecasting method, called non parametric forecasting .
Michel Carbon, Christian Francq
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Carbon and titanium diboride (TiB2) multilayer coatings. [PDF]

open access: yes, 2004
Titanium Diboride, (TiB2) is a metal-based refractory ceramic material that has been investigated in industrial applications ranging from, cutting tools to wear parts and for use in the aerospace industry.
Cruz, R.   +3 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Characterization of carbon contamination under ion and hot atom bombardment in a tin-plasma extreme ultraviolet light source [PDF]

open access: yes, 2014
Molecular contamination of a grazing incidence collector for extreme ultraviolet (EUV) lithography was experimentally studied. A carbon film was found to have grown under irradiation from a pulsed tin plasma discharge.
Bijkerk, F   +6 more
core   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Digital servitization and leadership: A holistic view on required leadership traits and skills [PDF]

open access: yesJournal of Entrepreneurship, Management and Innovation
PURPOSE: Digitalization and servitization are two major developments significantly disrupting companies’ competitive landscape. The research area that combines both aspects, digital servitization, poses substantial opportunities and challenges for ...
Florian Tagscherer   +1 more
doaj   +1 more source

Activated carbons as catalytic support for Cu nanoparticles [PDF]

open access: yes, 2018
There are a wide range of catalytic applications for Cu-based nanoparticles materials, since Cu is an abundant and inexpensive metal and Cu nanoparticles possess unusual electrical, thermal and optical properties.
Cordero, Tomás   +5 more
core  

A new paradigm of governance for a carbon-pricing system [PDF]

open access: yes, 2016
Throughout its life, the United Nations has played a pioneering role in the world of ideas. COP21 – also known as Paris 2015 – shows the path for the United Nations to establish a new governance that will enforce the compliance of a new planetary carbon ...
Berezin, A.   +2 more
core   +1 more source

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