Results 51 to 60 of about 528,430 (305)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Warming mineralises young and old soil carbon equally [PDF]
, 2006 The temperature sensitivity of soil organic carbon decomposition is critical for predicting future climate change because soils store 2-3 times the amount of atmospheric carbon.
Leifeld, J. +7 more
core +1 more source
A long-term high-resolution dataset of grasslands grazing intensity in China
Scientific DataGrazing is a significant anthropogenic disturbance to grasslands, impacting their function and composition, and affecting carbon budgets and greenhouse gas emissions.
Daju Wang +8 more
doaj +1 more source
Responses of soil detachment capacity to different rock dip angles in karst trough valley
GeodermaThe karst region is distinguished by pronounced and complex soil erosion, while the bedrock strata dip and root traits significantly influence the erosion slope, thereby altering the hydrodynamic characteristics and impacting Dc.
Lisha Jiang +6 more
doaj +1 more source
Evaluation and optimization of enhanced coagulation process: Water and energy nexus
Water-Energy Nexus, 2019 The rapid deterioration of water quality poses a serious threat and at the same time giving rise to an opportunity to the researchers for solving the problem cogently through innovative coagulation strategies.
Yongjun Sun +3 more
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
The contribution of weathering of the main Alpine rivers on the global carbon cycle [PDF]
, 2013 On geological time-scales the carbon fluxes from the solid Earth to the atmosphere mainly result from volcanism and metamorphic-decarbonation processes, whereas the carbon fluxes from atmosphere to solid Earth mainly depend on weathering of silicates and
Donnini, Marco +5 more
core
Optimization and Process Effect for Microalgae Carbon Dioxide Fixation Technology Applications Based on Carbon Capture: A Comprehensive Review [PDF]
, 2023 Microalgae carbon dioxide (CO2) fixation technology is among the effective ways of environmental protection and resource utilization, which can be combined with treatment of wastewater and flue gas, preparation of biofuels and other technologies, with ...
Tenglun Yang +7 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source