Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
A long-term high-resolution dataset of grasslands grazing intensity in China
Scientific DataGrazing is a significant anthropogenic disturbance to grasslands, impacting their function and composition, and affecting carbon budgets and greenhouse gas emissions.
Daju Wang +8 more
doaj +1 more source
Responses of soil detachment capacity to different rock dip angles in karst trough valley
GeodermaThe karst region is distinguished by pronounced and complex soil erosion, while the bedrock strata dip and root traits significantly influence the erosion slope, thereby altering the hydrodynamic characteristics and impacting Dc.
Lisha Jiang +6 more
doaj +1 more source
Evaluation and optimization of enhanced coagulation process: Water and energy nexus
Water-Energy Nexus, 2019 The rapid deterioration of water quality poses a serious threat and at the same time giving rise to an opportunity to the researchers for solving the problem cogently through innovative coagulation strategies.
Yongjun Sun +3 more
doaj +1 more source
The significance of organic carbon and nutrient export from peatland-dominated landscapes subject to disturbance, a stoichiometric perspective [PDF]
, 2009 The terrestrial-aquatic interface is a crucial environment in which to consider the fate of exported terrestrial carbon in the aquatic system. Here the fate of dissolved organic carbon (DOC) may be controlled by nutrient availability.
Arlaud, C. +4 more
core +2 more sources
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Sensitivity Analysis of Carbonate Looping Process Using Twin Fluidized Bed Model
Aerosol and Air Quality Research, 2020 CO2 as the major greenhouse gas plays an important role in environmental problems. Therefore, it is reasonable to find an effective technology for mitigating large CO2 emissions.
Xuan Yang +5 more
doaj +1 more source
An evaluation of the economic benefits of active cooling and carbon dioxide enrichment of greenhouse cucumbers (Cucumis sativus L.) : a thesis presented in partial fulfilment of the requirements for the degree of Master of Horticultural Science at Massey University [PDF]
, 1996 Cooling a greenhouse with a refrigeration system rather than conventional ventilation makes it possible to maximise the fractional enrichment time for carbon dioxide, and more importantly enrich during periods of high photosynthetically active radiation.
Van Heijst, Marcus Johannes Aart Everardus
core