Results 21 to 30 of about 21,417 (198)

PU-H71, a novel Hsp90 inhibitor, as a potential cancer-specific sensitizer to carbon-ion beam therapy

Journal of Radiation Research, 2016
PU-H71, a heat shock protein 90 (Hsp90) inhibitor, has yielded therapeutic efficacy in many preclinical models and is currently in clinical trials. Carbon-ion radiotherapy (CIRT) has provided successful tumor control; however, there is still room for ...
H. Li, Y. Matsumoto, Y. Furusawa, T. Kamada   +3 more
semanticscholar   +1 more source

Motion Management for Carbon Ion Therapy at the Heidelberg Ion-Beam Therapy Center [PDF]

, 2019
In 2011, stereotactic body radiotherapy was introduced for the treatment of hepatocellular carcinoma at the Heidelberg Ion-Beam Therapy Center (HIT). Initially, thirteen patients were treated, including the first patient treated using respiratory beam gating.
openaire   +1 more source

Performances of the beam monitoring system and quality assurance equipment for the HIMM of carbon‐ion therapy [PDF]

Journal of Applied Clinical Medical Physics, 2020
AbstractPurposeThe heavy‐ion medical machine (HIMM), which is the first commercial medical accelerator designed and built independently by the institute of modern physics (IMP) in Wuwei, Gansu Province, China, had officially completed clinical trials at the time of this article's writing.
Wei, Kun, Xu, Zhiguo, Mao, Ruishi, Zhao, Zulong, Zhao, Tiecheng, She, Qianshun, Kang, Xincai, Wang, Jianli, Li, Shengpeng, Li, Min, Song, Kai, Yang, Herun, Duan, Limin   +12 more
openaire   +2 more sources

Validation of robust radiobiological optimization algorithms based on the mixed beam model for intensity-modulated carbon-ion therapy

PLoS ONE, 2023
Currently, treatment planning systems (TPSs) that can compute the intensities of intensity-modulated carbon-ion therapy (IMCT) using scanned carbon-ion beams are limited.
M. Yagi, T. Tsubouchi, N. Hamatani, M. Takashina, Naoto Saruwatari, Kazumasa Minami, Yushi Wakisaka, S. Fujitaka, S. Hirayama, H. Nihongi, A. Hasegawa, M. Koizumi, S. Shimizu, K. Ogawa, T. Kanai   +14 more
semanticscholar   +1 more source

Energy-Loss Straggling and Delta-Ray Escape in Solid-State Microdosimeters Used in Ion-Beam Therapy

Journal of Nuclear Engineering, 2022
Microdosimetry is increasingly adopted in the characterization of proton and carbon ion beams used in cancer therapy. Spectra and mean values of lineal energy calculated in frequency and dose are seen by many as the tools which, by complementing ...
G. Magrin, S. Barna, C. Meouchi, A. Rosenfeld, H. Palmans   +4 more
semanticscholar   +1 more source

Neutron capture enhances dose and reduces cancer cell viability in and out of beam during helium and carbon ion therapy

bioRxiv, 2023
Purpose Neutron Capture Enhanced Particle Therapy (NCEPT) is a proposed augmentation of charged particle therapy which exploits thermal neutrons generated internally, within the treatment volume via nuclear fragmentation, to deliver a biochemically ...
Nicholas Howell, Ryan J. Middleton, Frederic Sierro, Naomi Wyatt, Andrew Chacon, Benjamin H. Fraser, Keith R. Bambery, Elle Livio, Chris Dobie, J. Bevitt, Justin B. Davies, A. Dosseto, Daniel R. Franklin, U. Garbe, S. Guatelli, R. Hirayama, Naruhiro Matsufuji, A. Mohammadi, Karl Mutimer, L. Rendina, Anatoly B. Rosenfeld, M. Safavi-Naeini   +21 more
semanticscholar   +1 more source

Slight Truncation Changes in Iron Oxide Nanocubes Strongly Affect Their Magnetic Properties

Advanced Functional Materials, EarlyView.
Subtle variations in nanoparticle morphology can lead to significant changes in functional properties. An automated shape‐fitting method captures minor differences in corner truncation between iron oxide nanocubes of similar sizes synthesized under identical conditions, revealing pronounced disparities in their magnetic and hyperthermia behavior ...
Kingsley Poon, Raúl López‐Martín, Verner Håkonsen, Nader Yaacoub, Francisco J. Terán, Alberto López Ortega, Jose A. De Toro, Gurvinder Singh   +7 more
wiley   +1 more source

Cyclic Olefin Copolymers as Versatile Materials for Advanced Engineering Applications

Advanced Functional Materials, EarlyView.
Cyclic olefin copolymers (COCs) are presented as highly versatile materials combining tunable synthesis, excellent optical properties, and mechanical robustness. Their potential spans microfluidics, bioengineering, and advanced electronics, while emerging self‐healing and sustainable solutions highlight future opportunities.
Giulia Fredi, Norma Mallegni, Andrea Dorigato, Mario Milazzo   +3 more
wiley   +1 more source

Phase Space Generation for Proton and Carbon Ion Beams for External Users’ Applications at the Heidelberg Ion Therapy Center [PDF]

Frontiers in Oncology, 2016
In the field of radiation therapy, accurate and robust dose calculation is required. For this purpose, precise modeling of the irradiation system and reliable computational platforms are needed. At the Heidelberg Ion Therapy Center (HIT), the beamline has been already modeled in the FLUKA Monte Carlo (MC) code. However, this model was kept confidential
Thomas eTessonnier, Thomas eTessonnier, Tiago eMarcelos, Andrea eMairani, Andrea eMairani, Stephan eBrons, Katia eParodi, Katia eParodi   +7 more
openaire   +4 more sources

Near‐Infrared Light‐Driven Zn/Au Janus Micromotors for Multiplex SERS Detection of Anticancer Drugs

Advanced Functional Materials, EarlyView.
Zn/Au Janus micromotors, propelled by thermophoretic effects under NIR light, function as active SERS platforms for single and multiplex detection of anticancer drugs. Their dynamic motion enhances analyte exchange at the Au interface, reducing saturation and competitive adsorption, thereby improving sensitivity and extending the linear detection range.
Tijana Maric, Gohar Soufi, Ziqiao Li, Erick Chica, Amran Abdirasheed Ali Jinow, Nada Al‐Roubaï, Noor Ahmed, Yaman Göksel, Anja Boisen   +8 more
wiley   +1 more source