Results 51 to 60 of about 52,149 (242)

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Diel variations in the carbon isotope composition of respired CO(2) and associated carbon sources: a review of dynamics and mechanisms

, 2011
Werner C, Gessler A. Diel variations in the carbon isotope composition of respired CO(2) and associated carbon sources: a review of dynamics and mechanisms. Biogeosciences.
Werner, Christiane ; https://orcid.org/, Geßler, Arthur, C. Werner, Gessler, A., A. Gessler, Werner, Christiane   +5 more
core   +1 more source

d13C pattern of dissolved inorganic carbon in a small granitic catchment: the Strengbach case study (Vosges mountains, France) [PDF]

, 1999
The transfers and origins of dissolved inorganic carbon DIC. were studied for a year in a soil–spring–stream system in the Strengbach catchment, Vosges mountains, France.
Amiotte Suchet, Philippe, P. Amiotte-Suchet, D. Viville, Amiotte-Suchet, P., Aubert, D., Andreux, F., Viville, Daniel, Probst, J.L., J.L. Probst, F. Gauthier-Lafaye, Probst, Jean-Luc, Aubert, Dominique, Probst, A., Gauthier-Lafaye, F., A. Probst, F. Andreux, Andreux, Francis, Viville, D., Probst, Anne, Gauthier-Lafaye, François, D. Aubert   +20 more
core   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Enantioselective Carbon Isotope Exchange

Journal of the American Chemical Society
The synthesis of isotopically labeled organic molecules is vital for drug and agrochemical discovery and development. Carbon isotope exchange is emerging as a leading method to generate carbon-labeled targets, which are sought over hydrogen-based labels due to their enhanced stability in biological systems.
Michael G. J. Doyle, Odey Bsharat, Anna Sib, Volker Derdau, Rylan J. Lundgren   +4 more
openaire   +2 more sources

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Hominin palaeoecology in Late Pliocene Malawi : first insights from isotopes (13C, 18O) in mammal teeth

, 2011
Carbon-13 and oxygen-18 abundances were measured in large mammal skeletal remains (tooth enamel, dentine and bone) from the Chiwondo Beds in Malawi, which were dated by biostratigraphic correlation to ca. 2.5 million years ago.
Kullmer, Ottmar, Hervé Bocherens, Bocherens, Herv é, Bocherens, Herv, Sandrock, Oliver, Friedemann Schrenk, Schrenk, Friedemann, Ottmar Kullmer, Oliver Sandrock   +8 more
core   +1 more source

Trophic interactions of meso- and macrozooplankton and fish in the Iceland Sea as evaluated by fatty acid and stable isotope analysis [PDF]

, 2012
A trophic study was carried out in August of 2007 and 2008 on the pelagic ecosystem in the Subarctic Iceland Sea. Carbon and nitrogen stable isotopes and fatty acid biomarkers were used to study trophic linkages and the trophic ecology of the most ...
Falk Petersen, Stig, Gislason, Astthor, Petursdottir, Hildur, Falk-petersen, Stig   +3 more
core   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source