Results 81 to 90 of about 51,201 (254)

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, EarlyView.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

Estimating global evapotranspiration and its components based on a modified Priestley–Taylor jet propulsion laboratory model

GIScience & Remote Sensing
Estimates of evapotranspiration (ET) and its components from satellite-based ET models have large uncertainties that hinder the understanding of the global terrestrial water cycle and its feedback to climate change.
Siyi Yang, Xiaojun Xu, Daodao Pan
doaj   +1 more source

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

Carbon-centered environmentally persistent free radicals induce stronger toxicity than oxygen-centered ones in earthworms (Eisenia fetida)

Environmental Chemistry and Ecotoxicology
Environmentally persistent free radicals (EPFRs) have attracted significant research interest regarding their generation and potential toxicities. However, conventional toxicity assessments of EPFRs have primarily relied on apparent concentrations ...
Hao Li, Xuqian Lu, Manling Zhang, Cai Long, Huijie Li, Di Lang, Wei Du, Zhaofeng Chang, Peng Zhang, Bo Pan, Baoshan Xing   +10 more
doaj   +1 more source

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

Advanced Science, EarlyView.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai, Keyu Wang, Jiali Fang, Shaorui Jia, Yansong Shi, Wanfeng Gao, Xinpeng Liu, Jiaqiang Li, Zenghui Cui, Yazhi Qian, Xiaosu Chen, Dan Ding, Xuetao Cao   +12 more
wiley   +1 more source

Designer Dynamic DNA Nanoaggregate in Living Cell for Mitochondrial Energy Restriction

Advanced Science, EarlyView.
This study presents the Tech‐tetrahedron, a designer dynamic DNA nanoaggregate engineered for precise mitochondrial energy restriction. Its trinity‐functionalized design integrates navigable unit, telomerase‐activated latch, and self‐assembly module.
Ruijia Deng, Jing Sheng, Ben Niu, Wenjuan Fu, Yingjie Yang, Zuowei Xie, Shuang Xie, Yunxuan He, Meilin Gong, Jue Wang, Yan Pi, Ming Chen, Kai Chang   +12 more
wiley   +1 more source

Improving Chinese Fir Plantations DBH Inversion Accuracy Using Ensemble Learning Models Base on UAV-LiDAR

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Diameter at breast height (DBH) is a fundamental measurement indicator in forest resource surveys. This study explores the use of uncrewed aerial vehicle light detection and ranging (UAV-LiDAR) for individual tree DBH inversion in Chinese fir ...
Jiuen Xu, Yinyin Zhao, Xuejian Li, Lujin Lv, Jiacong Yu, Meixuan Song, Lei Huang, Fangjie Mao, Huaqiang Du   +8 more
doaj   +1 more source

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Cosmopolitan marine bacteria facilitate a vast phytoplankton-derived sulfonate-based carbon flow through sulfoquinovosidases

Nature Communications
Sulfoquinovose (SQ) and sulfoquinovosyl glycerol (SQGro) are derived from abundant membrane sulfolipids termed sulfoquinovosyl diacylglycerols (SQDG) and produced by photosynthetic organisms, serving as sources of carbon and sulfur for bacteria.
Xiaoyi Ma, Huanyu Wang, Changjie Dong, Le Liu, Xuanyun Qiu, Xiaofeng Chen, Quanrui Chen, Liang Wang, Yao Zhang, Nianzhi Jiao, Spencer J. Williams, Kai Tang   +11 more
doaj   +1 more source

Landsat-based spatiotemporal estimation of subtropical forest aboveground carbon storage using machine learning algorithms with hyperparameter tuning

Frontiers in Plant Science
IntroductionThe aboveground carbon storage (AGC) in forests serves as a crucial metric for evaluating both the composition of the forest ecosystem and the quality of the forest.
Lei Huang, Lei Huang, Zihao Huang, Zihao Huang, Weilong Zhou, Sumei Wu, Xuejian Li, Xuejian Li, Fangjie Mao, Fangjie Mao, Meixuan Song, Meixuan Song, Yinyin Zhao, Yinyin Zhao, Lujin Lv, Lujin Lv, Jiacong Yu, Jiacong Yu, Huaqiang Du, Huaqiang Du   +19 more
doaj   +1 more source