Results 11 to 20 of about 79,056 (227)

Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis

Hepatology, EarlyView., 2022
Diagram of the activation of the profibrotic and procontractile Janus kinase 2 (JAK2)/Ras homolog family member A/Rho‐kinase pathway and the inhibition of phosphorylated JAK2 by pacritinib to inhibit hepatic stellate cell activity. Abstract Background and Aims Janus kinase 2 (JAK2) signaling is increased in human and experimental liver fibrosis with ...
Sandra Torres, Cristina Ortiz, Nadine Bachtler, Wenyi Gu, Leon D. Grünewald, Nico Kraus, Robert Schierwagen, Christoph Hieber, Caroline Meier, Olaf Tyc, Maximilian Joseph Brol, Frank Erhard Uschner, Bart Nijmeijer, Christoph Welsch, Marie‐Luise Berres, Carmen Garcia‐Ruiz, Jose Carlos Fernandez‐Checa, Christian Trautwein, Thomas J. Vogl, Stefan Zeuzem, Jonel Trebicka, Sabine Klein   +21 more
wiley   +1 more source

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

Protective Effect of Traditional Medicine Tagtaggunsel on Carbon Tetrachloride Induced Chronic Liver Cirrhosis in a Rat Model

Central Asian Journal of Medical Sciences, 2018
Objective: To study the effect of traditional medicine tagtaggunsel on the development of chronic cirrhosis in rat model. Methods: Rats were divided into 4 groups of 18 animals each.
Tsogtoo Bukhbayar, Dejidmaa Buyantogtokh, Chimedragchaa Chimedtseren, Badamsuren Dorjgotov   +3 more
doaj   +1 more source

An electron microscope study of liver cell in carbon tetrachloride intoxication, significance of "opaque area" [PDF]

, 1961
Electron microscope study on the rat liver cells of carbon tetrachloride poisoning has been reported. Observations have been made on the osmic fixed tissue sections obtained from the liver at early stages of poisoning, 5 to 22 hours after carbon ...
Haba, Kyoichi, Seno, Satimaru
core   +1 more source

The Protective Effect of Panax Ginseng Root Extract against the Toxicity of Carbon Tetrachloride that Induces Infertility to Male Rabbits

Al-Mustansiriyah Journal of Science, 2017
The present study used 20 male rabbits that divided randomly to four groups (each group consist 5 rabbits), control group received only normal diet, the group received carbon tetrachloride (CCL4) for forty days, the group treated (orally) with carbon ...
Layla A. S. Laylani
doaj   +1 more source

Effect of a Short Time Post Carbon Tetrachloride Treatment Interval on Rat Plasma Enzyme Levels and Percentage Mortality

Journal of Applied Sciences and Environmental Management, 2010
The effect of a short time (3 hours) post carbon tetrachloride treatment interval on rat plasma enzyme levels and percentage mortality have been examined.
FO Obi, LA Omogbai, OSJ Oriafo, OD Ovat
doaj   +1 more source

Chemical and biological investigations of Delonix regia (Bojer ex Hook.) Raf. [PDF]

, 2010
U radu je opisana izolacija pet sastojaka petroleterske i diklormetanske frakcije metanolnog ekstrakta kore biljke Delonix regia: lupeol (1), epilupeol (2), β-sitosterol (3), stigmasterol (4) i p-metoksibenzaldehid (5). Nadalje, testirano je antimikrobno
A. Bauer, Abdul Wahab, B. Meyer, B. Vanwagenen, F. Jungalwala, F. Maniruzzaman, G. Morales, Israt Jahan, J. McLaughlin, M. Rahman, Mohammad Islam, Mohammad Kaisar, Mohammad Rahman, Mohammad Rashid, Mohammed Rahman, O. Lawal, R. Harish, U. Kolak, Y. Aratanechemuge   +18 more
core   +3 more sources

IL-1Ra Protects Hepatocytes from CCl4-Induced Hepatocellular Apoptosis via Activating the ERK1/2 Pathway

Pharmaceutical Fronts, 2020
Interleukin-1 receptor antagonist is an important acute-phase protein and an immune mediator, and its expression is associated with the development of hepatitis or acute liver failure.
Ying Zheng, Xinyi Xiao, Zhuoyi Yang, Meiqi Zhou, Hui Chen, Siyi Bai, Jianwei Zhu, Yunsheng Yuan   +7 more
doaj   +1 more source

Comparisons of the effects of solute interactions on partition coefficient, kD, in selected binary immiscible solvents: a case of oxalic acid and succinic acid [version 1; peer review: 2 approved]

F1000Research, 2022
Background: The molecular distributions of solutes in binary immiscible solvents as used in partition coefficient technique serve as measures of the solute separation, concentration and beneficiation from contaminants.
Chukwu P. I., Onyeocha V. O., Onuchukwu A. I., Enemo R. E.   +3 more
doaj   +1 more source