Results 31 to 40 of about 2,002,576 (211)

L-glutamic acid effect on changes in biochemical parameters of rats intoxicated by carbon tetrachloride

, 2021
This study aims to explore the ameliorative effects of L-glutamic acid (L-Glu) against carbon tetrachloride (CCl4) toxicity in male rats. Changes in the activities of alanine and aspartate aminotransferases (ALAT, ASAT) were studied in the tissues and ...
N. O. Salyha
core   +1 more source

Elevated Liver Enzymes Is Not an Impediment to Allopurinol Dose Escalation: An Observational Cohort Study

Arthritis Care &Research, EarlyView.
Objective Routine liver enzyme monitoring is advocated for while on allopurinol, but supporting guidance is lacking. We assessed the incidence and factors associated with elevated liver enzyme levels in patients with gout commenced on allopurinol. Methods One hundred and fifty patients with gout and normal baseline serum aminotransferases initiated on ...
May Shuen Tang, Qai Ven Yap, Peter Pak Moon Cheung, Amelia Santosa, Gim Gee Teng   +4 more
wiley   +1 more source

Engineered Nanoplatforms Targeting Activated Hepatic Stellate Cells for Liver Fibrosis Therapy via TGF‐β Axis Inhibition and Ferroptosis Induction

Advanced Healthcare Materials, EarlyView.
FeS‐VA@lanifibranor (FVL), an activated hepatic stellate cell (aHSC)‐targeted nanoplatform comprising vitamin A‐functionalized two‐dimensional iron sulfide nanosheets and lanifibranor, is engineered for precision therapy of liver fibrosis. FVL suppresses the TGF‐β signaling pathway by inhibiting SMAD2/3 phosphorylation and induces ferroptosis in aHSCs,
Yinuo Yang, Mengyao Mu, Ke Ren, Hui Liu, Pengju Ma, Yingqi Wang, Mengmeng Zhang, Xueli Xu, Wenzhe Li, Wenshuang Gao, Xiao Sun, Qiang Zhu   +11 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

The study of the impact of zinc oxide nanoparticles and carbon tetrachloride on the liver of Rattus norvegicus

Pakistan Journal of Pharmaceutical Sciences, 2023
Cancer is a prevalent problem in modern times and while there are available treatments, it continues to cause a significant number of deaths. Cancer is a complex anomaly of the body that is becoming increasingly difficult to control. In the field of nano
Hamza Ahmad, Maria Siddique  Ghaffar ul Malik, Nighat Afroz, Hasnat Shabbir, Tayyaba Tahir   +4 more
doaj   +1 more source

Morphology of mitochondria and cell respiration,pt.1. [PDF]

, 1960
To reveal the mechanism of liver damage by taking CCl4 the author observed the liver tissues from rats at 1.5, 5, 6, 10, 17, 20, and 22 hours after the CCl4 administration, both by light microscope and electron-microscope. 1. Light microscope observation
Haba, Kyoichi
core   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Gut‐Liver Translocation of Bacteroides Uniformis Alleviates Advanced Metabolic Dysfunction‐Associated Steatotic Liver Disease by Suppressing Hepatocyte Ferroptosis via Propionic Acid Secretion

Advanced Science, EarlyView.
Systematic characterization of the liver‐resident microbiota in advanced metabolic dysfunction‐associated steatotic liver disease (MASLD) reveals a consistent depletion of Bacteroides uniformis (B. uniformis) in both hepatic and gut microbial communities. Oral gavage of B.
Haiyang Liu, Zun Fan, Zhen Liu, Lei Qin, Xin Zhao   +4 more
wiley   +1 more source

Study of the effect of wheat germ oilon carbon tetrachloride induced hepatic damage in adult male mice

Armaghane Danesh Bimonthly Journal, 2018
Background: Carbon tetrachloride, an organic solvent and chemical intermediate used in the industry, can cause numerous side effects including hepatotoxicity. This study was aimed to evaluate the possible hepatoprotective potential of wheat germ oil
Fatemeh Rezazadeh, Vahid Nejati, Ali Shalizar jalali, Gholamreza Najafi, Fatemeh Rahmani   +4 more
doaj  

Dissolution kinetics of natural FeS2 in carbon tetrachloride and water-carbon tetrachloride media saturated by chlorine

, 1996
The dissolution kinetics of natural pyrite samples in Cl-2-saturated carbon tetrachloride and water-carbon tetrachloride media have been investigated, The effects of pyrite particle size, reaction time, temperature, stirring speed and water-to-carbon ...
ÇOLAK, Sabri, KADIOĞLU, Yücel, BAYRAKÇEKEN, Samih   +2 more
core   +1 more source