Results 11 to 20 of about 25,186 (207)

Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis

Hepatology, EarlyView., 2022
Diagram of the activation of the profibrotic and procontractile Janus kinase 2 (JAK2)/Ras homolog family member A/Rho‐kinase pathway and the inhibition of phosphorylated JAK2 by pacritinib to inhibit hepatic stellate cell activity. Abstract Background and Aims Janus kinase 2 (JAK2) signaling is increased in human and experimental liver fibrosis with ...
Sandra Torres, Cristina Ortiz, Nadine Bachtler, Wenyi Gu, Leon D. Grünewald, Nico Kraus, Robert Schierwagen, Christoph Hieber, Caroline Meier, Olaf Tyc, Maximilian Joseph Brol, Frank Erhard Uschner, Bart Nijmeijer, Christoph Welsch, Marie‐Luise Berres, Carmen Garcia‐Ruiz, Jose Carlos Fernandez‐Checa, Christian Trautwein, Thomas J. Vogl, Stefan Zeuzem, Jonel Trebicka, Sabine Klein   +21 more
wiley   +1 more source

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

Effects of Aqueous Extract of Ocimum gratissimum Leaf on Carbon Tetrachloride-induced Nephrotoxicity in Adult Wistar rats

Journal of Applied Sciences and Environmental Management, 2022
This study investigated the effects of aqueous leaf extract of Ocimum gratissimumon enzymatic antioxidants and renal function in carbon tetrachloride-induced nephrotoxicity. Twenty-five (25) adult Wistar rats were involved in this study.
R. O. A Ehimigbai, P. Imariebe
doaj   +1 more source

Effect of a Short Time Post Carbon Tetrachloride Treatment Interval on Rat Plasma Enzyme Levels and Percentage Mortality

Journal of Applied Sciences and Environmental Management, 2010
The effect of a short time (3 hours) post carbon tetrachloride treatment interval on rat plasma enzyme levels and percentage mortality have been examined.
FO Obi, LA Omogbai, OSJ Oriafo, OD Ovat
doaj   +1 more source

PENGARUH WAKTU PROTEKSI INFUSA BIJI Persea americana Mill. TERHADAP HEPAR DAN GINJAL TIKUS TERINDUKSI KARBONTETRAKLORIDA

Jurnal Farmasi Sains dan Komunitas, 2014
: The aim of this research is to investigate the protective activity of the infusion of seed of Persea americana Mill. (IBPA) against carbon tetrachloride-induced hepatotoxicity and nephrotoxicity in rats.
Lydia Setiawan, Inneke Devi Permatasari, Phebe Hendra   +2 more
doaj   +1 more source

THE DANGERS OF CARBON TETRACHLORIDE. [PDF]

The Lancet, 1909
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openaire   +2 more sources

IL-1Ra Protects Hepatocytes from CCl4-Induced Hepatocellular Apoptosis via Activating the ERK1/2 Pathway

Pharmaceutical Fronts, 2020
Interleukin-1 receptor antagonist is an important acute-phase protein and an immune mediator, and its expression is associated with the development of hepatitis or acute liver failure.
Ying Zheng, Xinyi Xiao, Zhuoyi Yang, Meiqi Zhou, Hui Chen, Siyi Bai, Jianwei Zhu, Yunsheng Yuan   +7 more
doaj   +1 more source

Comparisons of the effects of solute interactions on partition coefficient, kD, in selected binary immiscible solvents: a case of oxalic acid and succinic acid [version 1; peer review: 2 approved]

F1000Research, 2022
Background: The molecular distributions of solutes in binary immiscible solvents as used in partition coefficient technique serve as measures of the solute separation, concentration and beneficiation from contaminants.
Chukwu P. I., Onyeocha V. O., Onuchukwu A. I., Enemo R. E.   +3 more
doaj   +1 more source

Protective Effect of Chemically Characterized Polyphenol-Rich Fraction from Apteranthes europaea (Guss.) Murb. subsp. maroccana (Hook.f.) Plowes on Carbon Tetrachloride-Induced Liver Injury in Mice

Applied Sciences, 2021
Apteranthes europaea (Guss.) Murb. subsp. maroccana (Hook.f.) Plowes (A. europaea) is a medicinal plant widely used in traditional medicines to treat various diseases including hepatic pathogenesis.
Fatima Ez-Zahra Amrati, Mohammed Bourhia, Meryem Slighoua, Smahane Boukhira, Riaz Ullah, Essam Ezzeldin, Gamal A. E. Mostafa, Andriy Grafov, Dalila Bousta   +8 more
doaj   +1 more source