Results 91 to 100 of about 1,477,943 (397)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sensitivity of the global carbonate weathering carbon-sink flux to climate and land-use changes [PDF]

, 2019
The response of carbonate weathering carbon-sink flux (CCSF) to its environmental drivers is still not well understood on the global scale. This hinders understanding of the terrestrial carbon cycle.
Kaufmann, Georg, Liu, Zaihua, Zeng, Sibo
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Reservoir geological modeling and significance of Cambrian Xiaoerblak Formation in Keping outcrop area, Tarim Basin, NW China

Petroleum Exploration and Development, 2020
: Take the Cambrian Xiaoerblak Formation in the Keping (Kalpin) outcrop area as an example, a 28 km reservoir scale geological model was built based on description of 7 profiles, observation of more than 1000 thin sections, petrophysical analysis of 556 ...
Jianfeng ZHENG, Wenqing PAN, Anjiang SHEN, Wenfang YUAN, Lili HUANG, Xinfeng NI, Yongjin ZHU   +6 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Impact of nitrogenous fertilizers on carbonate dissolution in small agricultural catchments: Implications for weathering CO2 uptake at regional and global scales [PDF]

, 2008
The goal of this study was to highlight the occurrence of an additional proton-promoted weathering pathway of carbonate rocks in agricultural areas where N-fertilizers are extensively spread, and to estimate its consequences on riverine alkalinity and ...
Perrin, Anne-Sophie, Probst, Anne, Probst, Jean-Luc   +2 more
core   +2 more sources

Calcium Carbonate Production, Coral Cover and Diversity along a Distance Gradient from Stone Town: A Case Study from Zanzibar, Tanzania

Frontiers in Marine Science, 2017
Photosymbiotic scleractinian corals are major bioengineers in tropical coastal waters, where they build structurally complex geological features and provide substrata for a manifold of macro and microhabitats. On a local scale, ecological competition and
Natalia Herrán, Natalia Herrán, Gita R. Narayan, Claire E. Reymond, Hildegard Westphal, Hildegard Westphal   +5 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

The Role of Diagenesis in Shaping the Geochemistry of the Marine Carbonate Record

Annual Review of Earth and Planetary Science, 2020
Carbonate sediments and rocks are valuable archives of Earth's past whose geochemical compositions inform our understanding of Earth's surface evolution.
M. Fantle, B. Davis Barnes, Kimberly V. Lau   +2 more
semanticscholar   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source