Results 221 to 230 of about 30,126 (308)

Linezolid‐mediated Prevention of Fibroblast Activation and Tissue Fibrosis via Mitochondrial Translation Inhibition

open access: yesArthritis &Rheumatology, EarlyView.
Objective Beyond its role as a ribosome‐targeting antibiotic, linezolid was recently shown to modulate immune responses by inhibiting mitochondrial translation. Because mitochondrial dysfunction is implicated in various fibrotic diseases, including systemic sclerosis (SSc), this study aimed to evaluate the antifibrotic potential of linezolid and ...
Xuezhi Hong   +13 more
wiley   +1 more source

Rock art from at least 67,800 years ago in Sulawesi. [PDF]

open access: yesNature
Oktaviana AA   +39 more
europepmc   +1 more source

Exposure to Occupational Inhalants and the Risk of Developing Rheumatoid Arthritis: A Systematic Review and Meta‐Analysis

open access: yesArthritis &Rheumatology, EarlyView.
Objective Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint pain, swelling, and stiffness. Although smoking is a well‐established risk factor for RA, the role of occupational inhalants in RA development is less well recognized.
Qianwen Liu   +7 more
wiley   +1 more source

Transient Transfection of Rolling‐Circle Amplified DNA in Biomanufacturing‐Relevant Mammalian Cell Lines: A Comparison of Transfection Conditions for Optimal Protein Expression

open access: yesBiotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Rolling‐circle amplification (RCA) is a completely synthetic and rapid mechanism for scaling‐up bulk DNA that eliminates requirements for large‐scale bacterial fermentation. Several reports have described the surprising ability of large unprocessed (hyperbranched) rolling circle‐amplified DNA (RCA DNA) to effectively transfect cultured cells ...
Evelina Loghin   +8 more
wiley   +1 more source

Socioenvironmental implications of Jatropha curcas cultivation for biodiesel supply in postmining communities

open access: yesBiofuels, Bioproducts and Biorefining, EarlyView.
Abstract The long‐term viability of Jatropha curcas as a biodiesel feedstock has been widely debated. Many early initiatives failed to deliver consistent economic returns despite promising environmental attributes. This study re‐evaluated J. curcas‐based systems within an integrated environmental–economic framework, focusing on their potential role in ...
Eduardo Sansão Sozinho Maurício   +3 more
wiley   +1 more source

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