Results 41 to 50 of about 28,884 (268)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Crystals, 2018 Although the minerals belonging to the carbonate group are a widely discussed subject, their relevance remains unchanged due to their many applications in a wide range of disciplines, from mineralogy, geochemistry and geology, to biology, medicine ...
Linda Pastero
doaj +1 more source
EXAMINATION OF THERMAL PROPERTIES OF CARBON-CARBON AND GRAPHATIZED CARBON-CARBON COMPOSITES
Frontiers in Heat and Mass Transfer, 2013 Thermal characterization is essential to the proper assignment of composites to specific applications. Specific heat, thermal diffusivity, and thermal conductivity are critical in the engineering design process and in the analysis of aerospace vehicles, space systems, power generation, transportation systems, and energy storage devices including fuel ...
Messiha Saad, Melanie Patrick
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Las sales solubles en el deterioro de rocas monumentales. Revisión bibliográfica
Materiales de Construccion, 1994 This paper points out the importance of soluble salts in the deterioration/conservation of monumental stones. The most frequent salts in monuments as well as their sources are referred.
C. M. Grossi, R M. Esbert
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Calclithites of the Krosno zone in the East Carpathians (Ukraine)
Вісник Київського національного університету імені Тараса Шевченка. Серія Геологія, 2017 Results of carbonates distribution in the flysch rocks of the Krosno Zone (Ukrainian Carpathians), which are composed mainly by interstratification of sandstones, argillites and aleurolites, and sporadically limestones, dolostones and marls as well as ...
V. Guliy +5 more
doaj +1 more source
Seismic Cycle in Bituminous Dolostones (Monte Camicia Thrust Zone, Central Apennines, Italy)
Geochemistry, Geophysics, Geosystems, 2023 Seismic ruptures often propagate along fault zones cutting km‐thick sequences of carbonates (e.g., Wenchuan Mw 7.8, 2008, China; L’Aquila Mw 6.1, 2009, Italy).
Miriana Chinello +5 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source