Results 51 to 60 of about 86,603 (302)

Stable oxygen and carbon isotope compositional fields for skeletal and diagenetic components in New Zealand Cenozoic nontropical carbonate sediments and limestones: A synthesis and review [PDF]

, 1996
The stable oxygen isotope composition (δ18O) of a precipitated carbonate depends mainly on the isotope composition, salinity, and temperature of the host fluid, whereas the stable carbon isotope composition (δ13C) reflects the source of CO2 for ...
Nelson, Campbell S., Campbell S. Nelson, Smith, Abigail M., Abigail M. Smith   +3 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Pd(II)/β-ICD-Cocatalyzed Asymmetric Route to Oxindole Scaffold via Cascade Reaction of Diazoacetamides and MBH-Carbonates

, 2016
We report an efficient method for asymmetric synthesis of chiral oxindoles. Allyl palladium­(II) chloride dimer (APC)-catalyzed, in combination with β-isocupreidine (β-ICD)-cocatalyzed, reaction of diazoacetamide with Morita–Baylis–Hillman (MBH ...
Chaoqun Ma (1867639), Wenhao Hu (523363), Yang Yang (45629), Nilesh J. Thumar (3091884)   +3 more
core   +1 more source

Construction of Hierarchical Porous Polycyanurate Networks with Cobaltoporphyrin for CO₂ Adsorption and Efficient Conversion to Cyclic Di- and Tri-Carbonates

, 2022
A new porphyrin-based cyanate monomer 5,10,15,20-tetrakis­(4-cyanatophenyl)-porphyrin (TCP) was synthesized, from which a porous polycyanurate network PCN–TCP was constructed by means of one-step thermal cyclotrimerization reaction.
Gen Li (743590), Xue Zhou (68629), Zhonggang Wang (1585960)   +2 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Permian Carbonates in the Venezuelan Andes [PDF]

, 2012
In northern South America, Upper Palaeozoic strata were deposited extensively over peri-cratonic areas associated with restricted seas located between Laurentia and Gondwana, in equatorial Pangea. In many places the successions are rarely exposed, and so
Laya-Pereira, Juan Carlos, LAYA-PEREIRA, JUAN,CARLOS   +1 more
core  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source