Results 121 to 130 of about 276,189 (369)

Classifying Hypoxia in Breast Cancer Xenografts Using a Single‐Cell Mass Spectrometry Imaging Model

open access: yesAnalysis &Sensing, EarlyView.
Hypoxia is a common feature in solid tumors and is linked to aggressiveness and therapy resistance. This study uses single‐cell mass spectrometry imaging of cultured cells exposed to different oxygen levels to spatially classify hypoxia in breast cancer xenografts.
Britt S. R. Claes   +7 more
wiley   +1 more source

Catecholamine-induced vasoconstriction is sensitive to carbonic anhydrase I activation

open access: yesBrazilian Journal of Medical and Biological Research, 2001
We studied the relationship between alpha- and beta-adrenergic agonists and the activity of carbonic anhydrase I and II in erythrocyte, clinical and vessel studies. Kinetic studies were performed.
Puscas I.   +6 more
doaj  

Novel Sulfonylhydrazones With Sulfonate Ester Framework: Promising Dual Inhibitors of AChE and hCAs

open access: yesBiotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects millions of individuals worldwide. Treatment strategies for AD vary depending on cognitive and behavioral symptoms, with cholinergic replacement therapy using acetylcholinesterase (AChE) inhibitors being one of the primary approaches.
Cansu Öztürk   +3 more
wiley   +1 more source

Human Carbonic Anhydrase II as Host Protein for the Creation of Artificial Metalloenzymes : the Asymmetric Transfer Hydrogenation of Imines

open access: yes, 2013
In the presence of human carbonic anhydrase II, aryl-sulfonamide-bearing IrCp* pianostool complexes catalyze the asymmetric transfer hydrogenation of imines. Critical cofactor–protein interactions revealed by the X-ray structure of [(η5-Cp*)Ir(pico 4)Cl]
F. Monnard   +4 more
semanticscholar   +1 more source

Challenges for the development of a biotic ligand model predicting copper toxicity in estuaries and seas [PDF]

open access: yes, 2012
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2011 SETAC.An effort is ongoing to develop a biotic ligand model (BLM) that predicts copper (Cu) toxicity in estuarine and marine ...
de Polo, A, Scrimshaw, MD
core   +1 more source

Exploring the multi-target enzyme inhibition potential of new sulfonamido-thiazoline derivatives; synthesis and computational studies

open access: yesResults in Chemistry, 2022
A small library of ten new Nimesulide-iminothiazolines conjugates was synthesized by the reduction of nitro group of Nimesulide followed by conversion into variously substituted acyl thioureas.
Imran Shafique   +9 more
doaj  

In vitro evaluation of ESE-15-ol, an estradiol analogue with nanomolar antimitotic and carbonic anhydrase inhibitory activity. [PDF]

open access: yesPLoS ONE, 2012
Antimitotic compounds are still one of the most widely used chemotherapeutic anticancer drugs in the clinic today. Given their effectiveness against cancer it is beneficial to continue enhancing these drugs.
Barend Andre Stander   +5 more
doaj   +1 more source

Mechanical Metastructures of Triple Periodic Carbon Clathrates [PDF]

open access: yesarXiv, 2020
Clathrates are lightweight, cage-like, fully-sp3 three dimensional (3D) structures that are experimentally-available for several host elements of the IV group. However, carbon clathrates are as yet hypothetical structures. Herein, the mechanical properties of Type-I-C46 Type-II-C34 and Type-H-C34 carbon clathrates are explored by first-principles ...
arxiv  

Medications, epilepsy and climate change: Added layers of complexity

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Climate change—the global crisis with pervasive health impacts—has adverse consequences for people with epilepsy (PWE) who have low quality of life due to poor seizure control, socioeconomic disadvantages and comorbidities. This review focuses on the potential effects of climate change on the pharmacological characteristics of antiseizure medications ...
Medine I. Gulcebi   +2 more
wiley   +1 more source

Water networks in fast proton transfer during catalysis by human carbonic anhydrase II.

open access: yesBiochemistry, 2013
Variants of human carbonic anhydrase II (HCA II) with amino acid replacements at residues in contact with water molecules in the active-site cavity have provided insights into the proton transfer rates in this protein environment.
R. Mikulski   +7 more
semanticscholar   +1 more source

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