Classifying Hypoxia in Breast Cancer Xenografts Using a Single‐Cell Mass Spectrometry Imaging Model
Hypoxia is a common feature in solid tumors and is linked to aggressiveness and therapy resistance. This study uses single‐cell mass spectrometry imaging of cultured cells exposed to different oxygen levels to spatially classify hypoxia in breast cancer xenografts.
Britt S. R. Claes+7 more
wiley +1 more source
Catecholamine-induced vasoconstriction is sensitive to carbonic anhydrase I activation
We studied the relationship between alpha- and beta-adrenergic agonists and the activity of carbonic anhydrase I and II in erythrocyte, clinical and vessel studies. Kinetic studies were performed.
Puscas I.+6 more
doaj
Novel Sulfonylhydrazones With Sulfonate Ester Framework: Promising Dual Inhibitors of AChE and hCAs
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects millions of individuals worldwide. Treatment strategies for AD vary depending on cognitive and behavioral symptoms, with cholinergic replacement therapy using acetylcholinesterase (AChE) inhibitors being one of the primary approaches.
Cansu Öztürk+3 more
wiley +1 more source
In the presence of human carbonic anhydrase II, aryl-sulfonamide-bearing IrCp* pianostool complexes catalyze the asymmetric transfer hydrogenation of imines. Critical cofactor–protein interactions revealed by the X-ray structure of [(η5-Cp*)Ir(pico 4)Cl]
F. Monnard+4 more
semanticscholar +1 more source
Challenges for the development of a biotic ligand model predicting copper toxicity in estuaries and seas [PDF]
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2011 SETAC.An effort is ongoing to develop a biotic ligand model (BLM) that predicts copper (Cu) toxicity in estuarine and marine ...
de Polo, A, Scrimshaw, MD
core +1 more source
A small library of ten new Nimesulide-iminothiazolines conjugates was synthesized by the reduction of nitro group of Nimesulide followed by conversion into variously substituted acyl thioureas.
Imran Shafique+9 more
doaj
In vitro evaluation of ESE-15-ol, an estradiol analogue with nanomolar antimitotic and carbonic anhydrase inhibitory activity. [PDF]
Antimitotic compounds are still one of the most widely used chemotherapeutic anticancer drugs in the clinic today. Given their effectiveness against cancer it is beneficial to continue enhancing these drugs.
Barend Andre Stander+5 more
doaj +1 more source
Mechanical Metastructures of Triple Periodic Carbon Clathrates [PDF]
Clathrates are lightweight, cage-like, fully-sp3 three dimensional (3D) structures that are experimentally-available for several host elements of the IV group. However, carbon clathrates are as yet hypothetical structures. Herein, the mechanical properties of Type-I-C46 Type-II-C34 and Type-H-C34 carbon clathrates are explored by first-principles ...
arxiv
Medications, epilepsy and climate change: Added layers of complexity
Climate change—the global crisis with pervasive health impacts—has adverse consequences for people with epilepsy (PWE) who have low quality of life due to poor seizure control, socioeconomic disadvantages and comorbidities. This review focuses on the potential effects of climate change on the pharmacological characteristics of antiseizure medications ...
Medine I. Gulcebi+2 more
wiley +1 more source
Water networks in fast proton transfer during catalysis by human carbonic anhydrase II.
Variants of human carbonic anhydrase II (HCA II) with amino acid replacements at residues in contact with water molecules in the active-site cavity have provided insights into the proton transfer rates in this protein environment.
R. Mikulski+7 more
semanticscholar +1 more source