Results 111 to 120 of about 41,221 (304)

Carbonic anhydrase II simulated with a universal neural network potential [PDF]

arXiv
The carbonic anhydrase II enzyme (CA II) is one of the most significant enzymes in nature, reversibly converting CO$_2$ to bicarbonate at a remarkable rate. The precise mechanism it uses to achieve this rapid turnover remains unclear due to our inability to directly observe or simulate the full process dynamically.
arxiv  

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

Exploration of Aromatic Hydrazides as Inhibitors of Human Carbonic Anhydrases. [PDF]

Arch Pharm (Weinheim)
Hydrazide‐based derivatives were evaluated as inhibitors of human carbonic anhydrase (hCA) isoforms I, II, IV, IX, and XII. Several derivatives, particularly those with ureido‐linkers, exhibited strong inhibitory activity with inhibition constants in the low micromolar range.
Menendez GB, Giovannuzzi S, Bonardi A, Nocentini A, Gratteri P, Supuran CT.   +5 more
europepmc   +2 more sources

Carbonic anhydrase 5 regulates acid-base homeostasis in zebrafish.

PLoS ONE, 2012
The regulation of the acid-base balance in cells is essential for proper cellular homeostasis. Disturbed acid-base balance directly affects cellular physiology, which often results in various pathological conditions. In every living organism, the protein
Ruben Postel, Arnoud Sonnenberg
doaj   +1 more source

THE ROLE OF CARBONIC ANHYDRASE IN CERTAIN IONIC EXCHANGES INVOLVING THE ERYTHROCYTE [PDF]

, 1942
M. H. Jacobs, Dorothy R. Stewart
openalex   +1 more source

Nanopattern on Carbon and by Carbon [PDF]

arXiv, 2013
We have reported nanopattern formation on carbon thin film and Si(100) surfaces by low energy inert and carbon ion beams. It is interesting to observe the role of carbon as target as well as projectile for nano patterning. Using carbon thin film as target, nano patterns of carbon are formed by inert (Ar+) and self (C+) ion bombardment, whereas carbon ...
arxiv  

Hyperbaric Oxygen Regulates Tumor pH to Boost Copper‐Doped Hydroxyethyl Starch Conjugate Nanoparticles Against Cancer Stem Cells

Exploration, EarlyView.
Hypoxia and acidic microenvironments are characteristic features of solid tumors, driving tumor growth, drug resistance, and metastasis. To address these issues, we combined hyperbaric oxygen therapy with rational designed hydroxyethyl starch‐doxorubicin‐copper nanoparticles to modulate the acidic microenvironment of tumors while enhancing the efficacy
Qingyuan Deng, Ao Hua, Shiyou Li, Zhijie Zhang, Xiang Chen, Qiang Wang, Xing Wang, Zhiqin Chu, Xiangliang Yang, Zifu Li   +9 more
wiley   +1 more source

Pharmacological inhibition of carbonic anhydrases with a positively charged pyridinium sulfonamide phenocopies the neuroprotective effects of Car9 genetic ablation in a murine setting of oxygen/glucose deprivation followed by re-oxygenation and is associated with improved neuronal function in ischemic rats

Heliyon
Carbonic anhydrases constitute a family of metalloenzymes vital for maintaining acid-base balance and regulating pH in physio-pathological processes. These findings suggest carbonic anhydrases as potential therapeutic targets for treating pH-associated ...
Sara Amiranda, Mariangela Succoio, Serenella Anzilotti, Ornella Cuomo, Tiziana Petrozziello, Valentina Tedeschi, Arianna Finizio, Giorgia Mele, Seppo Parkkila, Lucio Annunziato, Giuseppina De Simone, Giuseppe Pignataro, Agnese Secondo, Nicola Zambrano   +13 more
doaj  

Catalytically inactive carbonic anhydrase‐related proteins enhance transport of lactate by MCT1

FEBS Open Bio, 2019
Carbonic anhydrases (CA) catalyze the reversible hydration of CO2 to protons and bicarbonate and thereby play a fundamental role in the epithelial acid/base transport mechanisms serving fluid secretion and absorption for whole‐body acid/base regulation ...
Ashok Aspatwar, Martti E. E. Tolvanen, Hans‐Peter Schneider, Holger M. Becker, Susanna Narkilahti, Seppo Parkkila, Joachim W. Deitmer   +6 more
doaj   +1 more source

Molluscan Shells, Spicules, and Gladii Are Evolutionarily Deeply Conserved

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Evolutionarily conserved transcription factor encoding genes and other genes are expressed in the epithelia that give rise to spicules (green) and/or shells (blue) in developmental stages of diverse mollusks, including polyplacophorans, aplacophorans, scaphopods, and cephalopods.
Cristian Camillo Barrera Grijalba, Sonia Victoria Rodríguez Monje, Gabriela Ariza Aranguren, Kathrin Lunzer, Maik Scherholz, Emanuel Redl, Tim Wollesen   +6 more
wiley   +1 more source