Results 111 to 120 of about 27,386 (335)

Legionella pneumophila Carbonic Anhydrases: Underexplored Antibacterial Drug Targets

Pathogens, 2016
Carbonic anhydrases (CAs, EC 4.2.1.1) are metalloenzymes which catalyze the hydration of carbon dioxide to bicarbonate and protons. Many pathogenic bacteria encode such enzymes belonging to the α-, β-, and/or γ-CA families.
Claudiu T. Supuran
doaj   +1 more source

Toxicity evaluation of sulfamides and coumarins that efficiently inhibit human carbonic anhydrases

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Here, we report a toxicity study, conducted on zebrafish larvae, of a series of coumarin and sulfamide compounds that were previously reported as inhibitors of human (h) metalloenzymes, carbonic anhydrases (CAs, EC 4.2.1.1).
Ashok Aspatwar, Emanuela Berrino, Silvia Bua, Fabrizio Carta, Clemente Capasso, Seppo Parkkila, Claudiu T. Supuran   +6 more
doaj   +1 more source

Searching for novel carbonic anhydrase inhibitors: from virtual screening to the lab bench [PDF]

, 2013
Carbonic Anhydrases (CAs) are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide to bicarbonate both in prokaryotes and eukaryotes.
Cadoni, Roberta, Dallocchio, Roberto, Dessì, Alessandro, Ihm, Simone, Pala, Nicolino, Roggio, Anna Maria, Sechi, Mario, Supuran, Claudiu T., Weber, Rino   +8 more
core  

Pyrenoid loss impairs carbon-concentrating mechanism induction and alters primary metabolism in Chlamydomonas reinhardtii [PDF]

, 2017
Carbon-concentrating mechanisms (CCMs) enable efficient photosynthesis and growth in CO2-limiting environments, and in eukaryotic microalgae localisation of Rubisco to a microcompartment called the pyrenoid is key.
Madeline C Mitchell, Gergana Metodieva, Metodi V Metodiev, Howard Griffiths, Moritz T Meyer, Badger, Borkhsenious, Brueggeman, Caspari, Chen, Dionisio-Sese, Eriksson, Falda, Fang, Fukuzawa, Genkov, Giordano, Goodstein, Hochmal, Horton, Im, Jin, Karlsson, Karpievitch, Kelley, Kim, Krogh, Kropat, Lavigne, Lohse, Ma, Mackinder, McKew, Metodieva, Meyer, Mitchell, Miura, Morita, Moroney, Moroney, Raven, Reinfelder, Schloss, Schulze, Spalding, Spalding, Spalding, Spalding, Spalding, Spreitzer, Tardif, Tavío, Villarejo, Wang, Wang, Wang, Wang, Yamano, Yamano, Yamano, Zones   +60 more
core   +1 more source

Gold Nanoparticles–Dynamic Constitutional Frameworks as Adaptive Hybrid Conjugates for Enzyme Immobilization

ChemistryEurope, EarlyView.
Dynamic constitutional frameworks (DCFs) and gold nanoparticles (AuNps) assemble into larger and well‐distributed conjugates providing an efficient platform for biosensing and biocatalytic applications. Dynamic constitutional frameworks (DCFs), connecting monomers via reversible covalent bonds, can initiate the assembly of gold nanoparticles (AuNps ...
Sanaa Daakour, Rosalinda Mazzei, Fabio Bazzarelli, Giuseppe Vitola, Lidietta Giorno, Mihail Barboiu   +5 more
wiley   +1 more source

Естеразна активність чинника спряження CF₁, ізольованого з хлоропластів [PDF]

, 2017
Показано здатність ізольованого чинника спряження CF₁ — каталітичної частини ATФ-синтазного комплексу хлоропластів — каталізувати гідроліз п-нітрофенілового естеру оцтової кислоти. Специфічні інгібітори карбоангідрази — ацетазоламід (АА) і етоксизоламід (
Золотарьова, О.К., Михайленко, Н.Ф., Семеніхін, А.В., Хомочкін, А.П.   +3 more
core   +1 more source

Catalytic Amyloids: Turning Fibrils Into Biocatalysts

Chemistry – A European Journal, EarlyView.
Amyloids, traditionally associated with diseases, have emerged as versatile catalytic scaffolds. From natural amyloid sequences to bioinspired and de novo designs, we highlight strategies to construct catalytic active sites and anchor enzymes onto fibrils, creating versatile nanomaterials with tunable activities. ABSTRACT Amyloids have been regarded as
Alessandra Esposito, Linda Leone, Flavia Nastri, Angela Lombardi   +3 more
wiley   +1 more source

Comparative Study of the Antibacterial Activity of N, N-Diethylamido Substituted p-Toluenesulfonamides to their α-Toluenesulfonamide Counterparts [PDF]

, 2015
Reaction of p-toluenesulfonyl chloride with amino acids gave sulfonamides p-T1a-k which upon amidation afforded p-T2a-k. Similarly, treatment involving α-toluenesulfonyl chloride and amino acids afforded the sulfonamides α-T1a-k.
Adekoya, J. A.
core   +1 more source

Celecoxib Derivatives Containing Pyrazole Linked‐Sulfonamide Moiety: Carbonic Anhydrase I–II and Acetylcholinesterase Inhibition Profiles, Molecular Docking Studies [PDF]

, 2023
Serpil Gerni, Cansu Öztürk, Züleyha Almaz, Çetin Bayrak, Ayşe Tan   +4 more
openalex   +1 more source

Bottom‐up Strategies for Generating Polymer Protocells That Mimic Cellular Communication

Chemistry – A European Journal, EarlyView.
This review focuses on polymeric protocells produced using a bottom‐up approach. Polymer‐based assemblies guarantee stability and designability by adjusting the properties of the amphiphilic copolymers used. The review covers protocell architectures, production, and their intra‐ and intercellular communication mechanisms.
Gloria Saorin, Xinan Huang, Voichita Mihali, Cornelia G. Palivan   +3 more
wiley   +1 more source