Results 11 to 20 of about 34,597 (238)

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Palladium Iodide Catalyzed Multicomponent Carbonylative Synthesis of 2-(4-Acylfuran-2-yl)acetamides

Molecules, 2023
2-Propargyl-1,3-dicarbonyl compounds have been carbonylated under oxidative conditions and with the catalysis of the PdI2/KI catalytic system to selectively afford previously unreported 2-(4-acylfuran-2-yl)acetamides in fair to good yields (54–81%) over ...
Ida Ziccarelli, Lucia Veltri, Tommaso Prestia, Roberta Amuso, Maria A. Chiacchio, Raffaella Mancuso, Bartolo Gabriele   +6 more
doaj   +1 more source

Oxidative stress in Duchenne muscular dystrophy: focus on the NRF2 redox pathway [PDF]

, 2017
Oxidative stress is involved in the pathogenesis of Duchenne muscular dystrophy (DMD), an X-linked genetic disorder caused by mutations in the dystrophin gene and characterized by progressive, lethal muscle degeneration and chronic inflammation.
Bertini, Enrico, Catteruccia, Michela, D'Amico, Adele, FORCINA, LAURA, MUSARO', Antonio, PELOSI, LAURA, Petrillo, Sara, Petrini, Stefania, Piemonte, Fiorella, Travaglini, Lorena, Verardo, Margherita   +10 more
core   +5 more sources

Effect of chronic heat stress on the carbonylation of glycolytic enzymes in breast muscle and its correlation with the growth performance of broilers

Poultry Science, 2023
: Chronic heat stress has detrimental effects on the growth performance of broilers, and the potential mechanism is under exploration. In this study, the protein carbonyl modification was introduced to glycolytic enzymes to evaluate its relationship with
Yingsen Liu, Zhen Liu, Tong Xing, Jiaolong Li, Lin Zhang, Liang Zhao, Feng Gao   +6 more
doaj   +1 more source

Cell signaling promoting protein carbonylation does not cause sulfhydryl oxidation: implications to the mechanism of redox signaling [PDF]

, 2017
Reactive oxygen species (ROS) have been recognized as second messengers, however, targeting mechanisms for ROS in cell signaling have not been defined.
Almansour, Faisal, Cucinotta, Camilla, Marcocci, Lucia, Rybka, Vladyslava, Suzuki, Yuichiro J   +4 more
core   +3 more sources

Development of covalent triazine frameworks as heterogeneous catalytic supports [PDF]

, 2019
Covalent triazine frameworks (CTFs) are established as an emerging class of porous organic polymers with remarkable features such as large surface area and permanent porosity, high thermal and chemical stability, and convenient functionalization that ...
Krishnaraj, Chidharth, Leus, Karen, Tahir, Norini, Van Der Voort, Pascal   +3 more
core   +1 more source

Effective Synthesis of 4-Quinolones by Reductive Cyclization of 2′-Nitrochalcones Using Formic Acid as a CO Surrogate

Molecules, 2023
4-Quinolones are the structural elements of many pharmaceutically active compounds. Although several approaches are known for their synthesis, the introduction of an aryl ring in position 2 is problematic with most of them. The reductive cyclization of o-
Francesco Ferretti, Manar Ahmed Fouad, Cecilia Abbo, Fabio Ragaini   +3 more
doaj   +1 more source

Impact of Controlling the Site Distribution of Al Atoms on Catalytic Properties in Ferrierite-Type Zeolites [PDF]

, 2011
Zeolites with the ferrierite (FER) topology are synthesized using a combination of tetramethylammonium (TMA) cations with differently sized cyclic amines (pyrrolidine (Pyr), hexamethyleneimine (HMI), and 1,4- diazabicyclo[2.2.2]octane (DAB)).
Bhan A., Boronat M., Burton A., Carpenter J. R., Cheung P., Cheung P., Corma A., Fan W., Frillette V. J., Gabova V., Gabova V., Gies H., Gil B., Gómez-Hortigüela L., Jiang J., Jongkind H., Lewis J. E., Manuel Moliner, Mark E. Davis, Martínez-Alvarez C., Moliner M., Pinar A. B., Shantz D. F., Sun J., Wagner P., Wichterlova B., Yuriy Román-Leshkov, Zones S. I.   +27 more
core   +3 more sources

A New Pd-Based Catalytic System for the Reductive Carbonylation of Nitrobenzene to Form N-(4-hydroxyphenyl)acetamide Selectively in One Pot

Reactions, 2023
N-(4-hydroxyphenyl)acetamide (commonly named paracetamol or acetaminophen) is a target molecules for many industries that produce chemicals for pharmaceutical applications.
Andrea Vavasori, Marco Capponi, Lucio Ronchin   +2 more
doaj   +1 more source

Reactive Palladium–Ligand Complexes for ¹¹C-Carbonylation at Ambient Pressure: A Breakthrough in Carbon-11 Chemistry

Pharmaceuticals, 2023
The Pd–Xantphos-mediated 11C-carbonylation protocol (also known as the “Xantphos- method”), due to its simplistic and convenient nature, has facilitated researchers in meeting a longstanding need for preparing 11C-carbonyl-labeled radiopharmaceuticals at
Kenneth Dahl, Anton Lindberg, Neil Vasdev, Magnus Schou   +3 more
doaj   +1 more source