Protein Carbonylation as a Biomarker of Oxidative Stress and a Therapeutic Target in Neonatal Brain Damage [PDF]
Antioxidants, 2023 Oxidative stress (OS) constitutes a pivotal factor within the mechanisms underlying brain damage, for which the immature brain is particularly vulnerable.
José Martínez-Orgado +6 more
doaj +3 more sources
Protein Carbonylation: Emerging Roles in Plant Redox Biology and Future Prospects [PDF]
Plants, 2021 Plants are sessile in nature and they perceive and react to environmental stresses such as abiotic and biotic factors. These induce a change in the cellular homeostasis of reactive oxygen species (ROS).
Adesola J. Tola +2 more
doaj +3 more sources
Reactive oxygen species-induced protein carbonylation promotes deterioration of physiological activity of wheat seeds. [PDF]
PLoS ONE, 2022 During the seed aging process, reactive oxygen species (ROS) can induce the carbonylation of proteins, which changes their functional properties and affects seed vigor.
Bang-Bang Li +4 more
doaj +3 more sources
Protein Carbonylation and Lipid Peroxidation in Hematological Malignancies [PDF]
Antioxidants, 2020 Among the different mechanisms involved in oxidative stress, protein carbonylation and lipid peroxidation are both important modifications associated with the pathogenesis of several diseases, including cancer.
Alba Rodríguez-García +5 more
doaj +3 more sources
Proteome-wide analysis of hydrogen peroxide-induced protein carbonylation in Arabidopsis thaliana [PDF]
Frontiers in Plant Science, 2022 IntroductionProtein carbonylation is a non-enzymatic and irreversible post-translational modification that occurs naturally in living organisms under the direct or indirect effect of reactive oxygen species (ROS). In animals, signaling pathways involving
Georges Yannick Fangue-Yapseu +2 more
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Protein Carbonylation in Patients with Myelodysplastic Syndrome: An Opportunity for Deferasirox Therapy [PDF]
Antioxidants, 2019 Control of oxidative stress in the bone marrow (BM) is key for maintaining the interplay between self-renewal, proliferation, and differentiation of hematopoietic cells.
Alba Rodríguez-García +12 more
doaj +3 more sources
Specific protein carbonylation in human breast cancer tissue compared to adjacent healthy epithelial tissue. [PDF]
PLoS ONE, 2018 Protein carbonylation is an irreversible post-translational modification induced by severe oxidative stress. Reactive oxygen species (ROS) are constantly produced in cells and play important roles in both cancer progression and cancer suppression.
Baikuntha Aryal, V Ashutosh Rao
doaj +3 more sources
Protein carbonylation detection methods: A comparison [PDF]
Data in Brief, 2018 The data reported here are a comparison among four different methods for the detection of carbonylated proteins, a validated biomarker of oxidative stress.
Esra'a Alomari +5 more
doaj +3 more sources
Iron Availability Influences Protein Carbonylation in Arabidopsis thaliana Plants. [PDF]
Int J Mol Sci, 2023 Protein carbonylation is an irreversible form of post-translational modification triggered by reactive oxygen species in animal and plant cells. It occurs either through the metal-catalyzed oxidation of Lys, Arg, Pro, and Thr side chains or the addition ...
Tola AJ, Missihoun TD.
europepmc +2 more sources
Protein carbonylation in food and nutrition: a concise update. [PDF]
Amino Acids, 2022 Protein oxidation is a topic of indisputable scientific interest given the impact of oxidized proteins on food quality and safety. Carbonylation is regarded as one of the most notable post-translational modifications in proteins and yet, this reaction ...
Estévez M +2 more
europepmc +2 more sources