A novel two-way rebalancing strategy for identifying carbonylation sites
BMC Bioinformatics, 2023 Background As an irreversible post-translational modification, protein carbonylation is closely related to many diseases and aging. Protein carbonylation prediction for related patients is significant, which can help clinicians make appropriate ...
Linjun Chen +5 more
doaj +1 more source
Combined Intake of Fish Oil and D-Fagomine Prevents High-Fat High-Sucrose Diet-Induced Prediabetes by Modulating Lipotoxicity and Protein Carbonylation in the Kidney. [PDF]
Antioxidants (Basel), 2023 Obesity has been recognized as a major risk factor for chronic kidney disease, insulin resistance being an early common metabolic feature in patients suffering from this syndrome.
Méndez L +7 more
europepmc +2 more sources
The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro +14 more
wiley +1 more source
Reciprocal carbonyl–carbonyl interactions in small molecules and proteins [PDF]
Nature Communications, 2017 AbstractCarbonyl-carbonyl n→π* interactions where a lone pair (n) of the oxygen atom of a carbonyl group is delocalized over the π* orbital of a nearby carbonyl group have attracted a lot of attention in recent years due to their ability to affect the 3D structure of small molecules, polyesters, peptides, and proteins.
Abdur Rahim +4 more
openaire +3 more sources
CarSPred: a computational tool for predicting carbonylation sites of human proteins. [PDF]
PLoS ONE, 2014 Protein carbonylation is one of the most pervasive oxidative stress-induced post-translational modifications (PTMs), which plays a significant role in the etiology and progression of several human diseases.
Hongqiang Lv +5 more
doaj +1 more source
Adipose oxidative stress and protein carbonylation. [PDF]
J Biol Chem, 2019 Increased oxidative stress and abundance of reactive oxygen species (ROS) are positively correlated with a variety of pathophysiologies, including cardiovascular disease, type 2 diabetes, Alzheimer's disease, and neuroinflammation. In adipose biology, diabetic obesity is correlated with increased ROS in an age- and depot-specific manner and is ...
Hauck AK +3 more
europepmc +4 more sources
Protein Carbonylation Sites Prediction using Biomarkers of Oxidative Stress in Various Human Diseases: A Systematic Literature Review [PDF]
, 2021 Protein carbonylation is a non-enzymatic, irreversible, post translational modification (PTM). Carbonylation basically occurs due to the ROS, these species cause the oxidation of proteins and it will lead towards post translational modification of ...
Ashraf, Adeel +2 more
core +1 more source
A Simplified Method to Assay Protein Carbonylation by Spectrophotometry
, 2022 International audienceProtein carbonylation is an irreversible oxidation process leading to a loss of function of carbonylatedproteins. Carbonylation is largely considered as a hallmark of oxidative stress, the level of protein carbonyl-ation being an ...
Issakidis-Bourguet, Emmanuelle +3 more
core +1 more source
Protein Carbonylation and Decarboylation [PDF]
Circulation Research, 2008 See related article, pages 310–318 Although the Greek physician Galenos (129 to 216 AD) recognized early that ventilation of the lungs is important for the transfer of an unknown substance from the air into the blood, it took surprisingly long to discover that oxygen is a major “fuel” for our metabolism that oxidizes nutrients to generate ...
Marco Cattaruzza, Markus Hecker
openaire +1 more source
Redox proteomics identification of oxidatively modified myocardial proteins in human heart failure: implications for protein function. [PDF]
PLoS ONE, 2012 Increased oxidative stress in a failing heart may contribute to the pathogenesis of heart failure (HF). The aim of this study was to identify the oxidised proteins in the myocardium of HF patients and analyse the consequences of oxidation on protein ...
Maura Brioschi +6 more
doaj +1 more source