Protein Carbonylation and Adipocyte Mitochondrial Function [PDF]
Journal of Biological Chemistry, 2012 Carbonylation is the covalent, non-reversible modification of the side chains of cysteine, histidine, and lysine residues by lipid peroxidation end products such as 4-hydroxy- and 4-oxononenal. In adipose tissue the effects of such modifications are associated with increased oxidative stress and metabolic dysregulation centered on mitochondrial energy ...
Curtis, Jessica M. +12 more
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ASN Neuro, 2012 While the build-up of oxidized proteins within cells is believed to be toxic, there is currently no evidence linking protein carbonylation and cell death.
Anushka Dasgupta +2 more
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Targeting Hepatic Protein Carbonylation and Oxidative Stress Occurring on Diet-Induced Metabolic Diseases through the Supplementation with Fish Oils. [PDF]
Mar Drugs, 2018 The present study addressed the ability of long-chain ω-3 polyunsaturated fatty acids (ω-3 PUFA), i.e., eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), to ameliorate liver protein damage derived from oxidative stress and induced by ...
Muñoz S +7 more
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MDD-carb: a combinatorial model for the identification of protein carbonylation sites with substrate motifs. [PDF]
BMC Syst Biol, 2017 BackgroundCarbonylation, which takes place through oxidation of reactive oxygen species (ROS) on specific residues, is an irreversibly oxidative modification of proteins.
Kao HJ +6 more
europepmc +2 more sources
Effects of chronic heat stress on Ca2+ homeostasis, apoptosis, and protein carbonylation profiles in the breast muscle of broilers [PDF]
Poultry Science: Heat stress (HS) largely impairs the quality of broiler breast meat through protein oxidative modification. This study aimed to investigate the carbonylation pattern of Ca2+ channels and apoptotic proteins in the breast muscle of heat-stressed broilers.
Yingsen Liu +6 more
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Protein carbonylation, cellular dysfunction, and disease progression [PDF]
Journal of Cellular and Molecular Medicine, 2006 Carbonylation of proteins is an irreversible oxidative damage, often leading to a loss of protein function, which is considered a widespread indicator of severe oxidative damage and disease-derived protein dysfunction. Whereas moderately carbonylated proteins are degraded by the proteasomal system, heavily carbonylated proteins tend to form high ...
I. Dalle Donne +5 more
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Plasma Protein Carbonylation in Haemodialysed Patients: Focus on Diabetes and Gender. [PDF]
Oxid Med Cell Longev, 2018 Patients with end-stage renal disease (ESRD) undergoing haemodialysis (HD) experience oxidative/carbonyl stress, which is postulated to increase after the HD session.
Colombo G +10 more
europepmc +2 more sources
Obesity-induced protein carbonylation in murine adipose tissue regulates the DNA-binding domain of nuclear zinc finger proteins. [PDF]
J Biol Chem, 2018 In obesity-linked insulin resistance, oxidative stress in adipocytes leads to lipid peroxidation and subsequent carbonylation of proteins by diffusible lipid electrophiles.
Hauck AK +6 more
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Stress-Specific Carbonylation and Proteasome 20S Activity in Potato Under Drought, Elevated Temperature, and Combined Stresses: Linking Oxidative Damage to Proteome Regulation [PDF]
PlantsDrought and elevated temperature are major abiotic stresses that limit potato growth and productivity; however, their combined effects on biomass and oxidative damage to proteins remain poorly understood.
Dominika Boguszewska-Mańkowska +3 more
doaj +2 more sources
ASN Neuro, 2013 Previous work from our laboratory implicated protein carbonylation in the pathophysiology of both MS (multiple sclerosis) and its animal model EAE (experimental autoimmune encephalomyelitis).
Anushka Dasgupta +3 more
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