Results 11 to 20 of about 13,056 (198)
Protein Carbonylation and Adipocyte Mitochondrial Function [PDF]
Journal of Biological Chemistry, 2012 Carbonylation is the covalent, non-reversible modification of the side chains of cysteine, histidine, and lysine residues by lipid peroxidation end products such as 4-hydroxy- and 4-oxononenal. In adipose tissue the effects of such modifications are associated with increased oxidative stress and metabolic dysregulation centered on mitochondrial energy ...
Matthew D Stone +2 more
exaly +5 more sources
ASN Neuro, 2012 While the build-up of oxidized proteins within cells is believed to be toxic, there is currently no evidence linking protein carbonylation and cell death.
Anushka Dasgupta +2 more
doaj +3 more sources
Cell Signaling by Protein Carbonylation and Decarbonylation [PDF]
Antioxidants & Redox Signaling, 2010 Reactive oxygen species (ROS) serve as mediators of signal transduction. However, mechanisms of how ROS influence the target molecules to elicit signaling event have not been defined. Our laboratory recently accumulated evidence for the role of protein carbonylation in the mechanism of ROS signaling.
Chi Ming, Wong +3 more
openaire +4 more sources
Specific protein carbonylation in human breast cancer tissue compared to adjacent healthy epithelial tissue. [PDF]
PLoS ONE, 2018 Protein carbonylation is an irreversible post-translational modification induced by severe oxidative stress. Reactive oxygen species (ROS) are constantly produced in cells and play important roles in both cancer progression and cancer suppression.
Baikuntha Aryal, V Ashutosh Rao
doaj +2 more sources
Quantitation of protein carbonylation by dot blot [PDF]
Analytical Biochemistry, 2012 Protein carbonylation is the most commonly used measure of oxidative modification of proteins. It is frequently measured spectrophotometrically or immunochemically by derivatizing proteins with the classical carbonyl reagent, 2,4-dinitrophenylhydrazine.
Nancy B Wehr, Rodney L Levine
exaly +3 more sources
Protein carbonylation and metabolic control systems [PDF]
Trends in Endocrinology and Metabolism, 2012 Oxidative stress is linked to the production of reactive lipid aldehydes that non-enzymatically alkylate cysteine, histidine, or lysine residues in a reaction termed protein carbonylation. Reactive lipid aldehydes and their derivatives are detoxified via a variety of phase I and phase II systems, and when antioxidant defenses are compromised or ...
Eric K Long +2 more
exaly +3 more sources
Adipose oxidative stress and protein carbonylation. [PDF]
J Biol Chem, 2019 Increased oxidative stress and abundance of reactive oxygen species (ROS) are positively correlated with a variety of pathophysiologies, including cardiovascular disease, type 2 diabetes, Alzheimer's disease, and neuroinflammation. In adipose biology, diabetic obesity is correlated with increased ROS in an age- and depot-specific manner and is ...
Hauck AK +3 more
europepmc +4 more sources
ASN Neuro, 2013 Previous work from our laboratory implicated protein carbonylation in the pathophysiology of both MS (multiple sclerosis) and its animal model EAE (experimental autoimmune encephalomyelitis).
Anushka Dasgupta +3 more
doaj +2 more sources
Effects of chronic heat stress on Ca2+ homeostasis, apoptosis, and protein carbonylation profiles in the breast muscle of broilers [PDF]
Poultry Science: Heat stress (HS) largely impairs the quality of broiler breast meat through protein oxidative modification. This study aimed to investigate the carbonylation pattern of Ca2+ channels and apoptotic proteins in the breast muscle of heat-stressed broilers.
Yingsen Liu +6 more
doaj +2 more sources
Stress-Specific Carbonylation and Proteasome 20S Activity in Potato Under Drought, Elevated Temperature, and Combined Stresses: Linking Oxidative Damage to Proteome Regulation [PDF]
PlantsDrought and elevated temperature are major abiotic stresses that limit potato growth and productivity; however, their combined effects on biomass and oxidative damage to proteins remain poorly understood.
Dominika Boguszewska-Mańkowska +3 more
doaj +2 more sources