Adipose oxidative stress and protein carbonylation. [PDF]
J Biol Chem, 2019 Increased oxidative stress and abundance of reactive oxygen species (ROS) are positively correlated with a variety of pathophysiologies, including cardiovascular disease, type 2 diabetes, Alzheimer's disease, and neuroinflammation.
Hauck AK +3 more
europepmc +5 more sources
Functionalized Au15 nanoclusters as luminescent probes for protein carbonylation detection. [PDF]
Commun Chem, 2021 Atomically precise, ligand-protected gold nanoclusters (AuNCs) attract considerable attention as contrast agents in the biosensing field. However, the control of their optical properties and functionalization of surface ligands remain challenging.
Combes GF +16 more
europepmc +2 more sources
Rules governing selective protein carbonylation. [PDF]
PLoS ONE, 2009 BACKGROUND:Carbonyl derivatives are mainly formed by direct metal-catalysed oxidation (MCO) attacks on the amino-acid side chains of proline, arginine, lysine and threonine residues.
Etienne Maisonneuve +6 more
doaj +5 more sources
Explainable Deep Multilevel Attention Learning for Predicting Protein Carbonylation Sites [PDF]
Advanced ScienceProtein carbonylation refers to the covalent modification of proteins through the attachment of carbonyl groups, which arise from oxidative stress. This modification is biologically significant, as it can elicit modifications in protein functionality ...
Jian Zhang +6 more
doaj +2 more sources
Detection of Protein Carbonylation in Gingival Biopsies from Periodontitis Patients with or Without Diabetes Mellitus—A Pilot Study [PDF]
Dentistry JournalBackground: Protein carbonylation is an irreversible post-translational modification that is considered indicative of oxidative damage. Objective: The purpose of the study was to examine by an immunohistochemical method for the first time the extent and ...
Alexandra Efthymiou +5 more
doaj +2 more sources
Andrologia, 2019 The cryopreservation of sperm is a well established technique that plays an essential role in dissemination of elite germplasm of livestock. Despite having numerous advantages, the cryopreservation induces certain stresses on sperm including structural ...
S. Lone +3 more
semanticscholar +3 more sources
Protein carbonylation and metabolic control systems [PDF]
Trends in Endocrinology & Metabolism, 2012 Oxidative stress is linked to the production of reactive lipid aldehydes that non-enzymatically alkylate cysteine, histidine, or lysine residues in a reaction termed protein carbonylation. Reactive lipid aldehydes and their derivatives are detoxified via a variety of phase I and phase II systems, and when antioxidant defenses are compromised or ...
Jessica M, Curtis +5 more
openaire +4 more sources
Toxic consequences and oxidative protein carbonylation from chloropicrin exposure in human corneal epithelial cells. [PDF]
Toxicol Lett, 2020 Chloropicrin (CP), a warfare agent now majorly used as a soil pesticide, is a strong irritating and lacrimating compound with devastating toxic effects.
Goswami DG +8 more
europepmc +2 more sources
Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging. [PDF]
Aging (Albany NY), 2018 Non-enzymatic protein modifications occur inevitably in all living systems. Products of such modifications accumulate during aging of cells and organisms and may contribute to their age-related functional deterioration. This review presents the formation
Gonos ES +6 more
europepmc +2 more sources
Hepatic protein Carbonylation profiles induced by lipid accumulation and oxidative stress for investigating cellular response to non-alcoholic fatty liver disease in vitro. [PDF]
Proteome Sci, 2019 Non-alcoholic fatty liver disease (NAFLD) is caused by excessive accumulation of fat within the liver, leading to further severe conditions such as non-alcoholic steatohepatitis (NASH).
Chienwichai P +7 more
europepmc +2 more sources