Rapid Response to Trametinib Combined With Chemotherapy for Infant BRAF‐Fused Chiasmatic Glioma
ABSTRACT Infants, less than 1 year, with chiasmatic gliomas (ICG) present a major therapeutic challenge due to large tumor size, decreased vision, rapid progression, and poor response to vincristine/carboplatin chemotherapy. The majority have a BRAF fusion, which may respond to downstream MEK inhibitors but response time is slow. There are no safety or
Helen Toledano +7 more
wiley +1 more source
Eicosapentaenoic Acid Suppresses Tumor Growth and Enhances Chemosensitivity via AKT/mTOR Signaling in Uterine Serous Carcinoma. [PDF]
Zhang H +9 more
europepmc +1 more source
PD‐L1‐Inhibitor‐Associated Hidradenitis Suppurativa
Journal of Cutaneous Pathology, EarlyView.
Annie Jin +2 more
wiley +1 more source
ABSTRACT Although most malignant germ cell tumors (GCTs) are highly curable with cisplatin‐based therapy, options for patients with multiply relapsed/refractory disease remain limited. For this population, we report the first pediatric use of gemcitabine, docetaxel, melphalan, and carboplatin (GemDMC) as part of sequential cycles of high‐dose ...
Maria Frost +10 more
wiley +1 more source
Comparative carboplatin pharmacokinetics in four different avian species [PDF]
Antonissen, Gunther +6 more
core +1 more source
ABSTRACT Background Childhood cancer survivors (CCS) have an increased risk of long‐term health complications, including treatment‐related hearing loss. Although early detection is important, many adult survivors do not attend hearing screenings in clinical centers because visits can be logistically or emotionally burdensome.
Philippa Jörger +9 more
wiley +1 more source
Distortion product otoacoustic emission (DPOAE) reveals hearing loss up to 16 kHz in pediatric chemotherapy patients. [PDF]
Hecker DJ +11 more
europepmc +1 more source
Dacomitinib, a pan-inhibitor of ErbB receptors, suppresses growth and invasive capacity of chemoresistant ovarian carcinoma cells [PDF]
et al,, Ghasemi, Reza
core +2 more sources
Chemotherapy treatment experiments were conducted on three breast cancer cell lines cultured in 2D, spheroids, and the novel 3D support: FN‐silk networks. The breast cancer cells cultured in FN‐silk networks were generally less sensitive to the drugs tested, compared to 2D cultures, potentially giving higher clinical relevance.
Suha Karrani +5 more
wiley +1 more source
Chloroquine Potentiates the Chemotherapeutic Effect of Carboplatin and ATR/Chk1 Inhibitors by Increasing the Replication Stress. [PDF]
Zamkova M +3 more
europepmc +1 more source

