Results 191 to 200 of about 129,195 (289)

Results of the Childhood Cancer and Leukaemia Group's United Kingdom Relapsed Wilms Tumour Trial

Pediatric Blood &Cancer, Volume 73, Issue 5, May 2026.
ABSTRACT Background The United Kingdom relapsed Wilms tumour (UKW‐R) trial aimed to improve the historically low survival rates after relapse of Wilms tumour (WT) through a prospective national risk‐stratified protocol. The trial also evaluated efficacy and toxicity of high‐dose melphalan.
Sucheta J. Vaidya, Veronica Moroz, Juliet Hale, Vesna Pavasovic, Rachel Hobson, Patricia Sartori, Daniel Saunders, Mark Powis, Gordan M. Vujanic, Stephen Baker, Kathy Pritchard‐Jones   +10 more
wiley   +1 more source

Evaluating carboplatin and PARP inhibitor combination efficacy using high-grade serous carcinoma spheroids and organoids. [PDF]

Cancer Biol Ther
Tomas EJ, Davis J, Ramos Valdes Y, Shepherd TG.   +3 more
europepmc   +1 more source

The Efficacy and Safety of Bevacizumab/Irinotecan/Temozolomide (BIT) for Relapsed/Refractory Neuroblastoma: The UK Children's Cancer and Leukaemia Group Experience

Pediatric Blood &Cancer, Volume 73, Issue 5, May 2026.
ABSTRACT Background Patients with high‐risk neuroblastoma who either are refractory to induction chemotherapy or relapse following multi‐modal treatment have a dismal prognosis. Based on data from the BEACON trial, since 2021 the UK national guidelines recommend bevacizumab, irinotecan, and temozolomide (BIT) for patients with relapsed/refractory ...
Thomas J. Jackson, Menna Shamma, Upeka Senanayake, Shaimaa Sahmoud, Kathleen Duffin, Victoria Howard, David King, Ayesha Fathani, Blanche Lumb, Andrei Pobischan, Irum Latif Memon, Monzir Ahmed, Rhian Thomas, Gerard Millen, Yasmeen Alomari, Sucheta Vaidya, Lynley V. Marshall, Sally L. George, Ramya Ramanujachar, Juliet Gray, Paola Angelini   +20 more
wiley   +1 more source

Losartan, toceranib, and carboplatin combination therapy for progressive pulmonary metastasis in canine osteosarcoma: a case report. [PDF]

Ir Vet J
Kwak JH, Jung M, Choi SN, Jeong KS.
europepmc   +1 more source

Chemosensory response to Pt-based chemotherapeutics via bitter taste receptors in vitro reveals a new mechanism for bitter taste disorders. [PDF]

Sci Rep
Zehentner S, Mistlberger-Reiner A, Pirkwieser P, Orth N, Boger V, Kahlenberg K, Kreißl J, Grimm C, Ley JP, Somoza V.   +9 more
europepmc   +1 more source

Molecular subtype concordance and metastatic patterns in muscle‐invasive bladder cancer

The Journal of Pathology: Clinical Research, Volume 12, Issue 3, May 2026.
Abstract Molecular subtypes are potential prognostic and predictive tools in muscle‐invasive bladder cancer (MIBC). However, subtype concordance between primary tumors and metastases, as well as subtype‐specific differences in metastatic patterns, remain poorly characterized.
Csilla Olah, Dániel Juhász, Melinda Váradi, Henning Reis, Mulham Al‐Nader, Osama Mahmoud, Barbara T. Grünwald, Viktor Grünwald, Boris Hadaschik, Péter Nyirády, Tibor Szarvas   +10 more
wiley   +1 more source

Tumor-Infiltrating Nociceptor Neurons in Ovarian Cancer Treatment Resistance. [PDF]

Adv Biol (Weinh)
Jorgensen A, Vermeer DW, Jung E, Williamson CS, Omran DK, Schwartz LE, Yoon JY, Barr J, Tetlow AL, Trinidad CV, Drapkin R, Godwin AK, Vermeer PD.   +12 more
europepmc   +1 more source

Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

Advanced Materials Technologies, Volume 11, Issue 9, 6 May 2026.
This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang, He Huang, Hongliang Dong, Qiang Ma, Hongyan Jin   +4 more
wiley   +1 more source

Severe multiorgan toxicities after the first cycle of standard-dose etoposide-cisplatin therapy for metastatic nonseminoma successfully managed with etoposide-carboplatin: a case report. [PDF]

J Med Case Rep
Mochizuki T, Sawada N, Nakanishi Y, Kira S, Mitsui T.   +4 more
europepmc   +1 more source