Results 71 to 80 of about 296,130 (365)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Exploring the cocrystallization potential of urea and benzamide [PDF]

, 2018
The cocrystallization landscape of benzamide and urea interacting with aliphatic and aromatic carboxylic acids was studied both experimentally and theoretically. Ten new cocrystals of benzamide were synthesized using an oriented samples approach via a fast dropped evaporation technique. Information about types of known bi-component cocrystals augmented
arxiv   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

An ISFET-based anion sensor for the potentiometric detection of organic acids in liquid chromatography [PDF]

, 2000
An ion-selective field effect transistor (ISFET) was applied as a potentiometric detector in liquid chromatography (LC) for the determination of organic acids.
Berg, A. van den, Dedem, G.W.K. van, Frank, J., Nagels, L.J., Picioreanu, S., Poels, I., Schasfoort, R.B.M.   +6 more
core   +2 more sources

Mapping Hsp104 interactions using cross‐linking mass spectrometry

FEBS Open Bio, EarlyView.
This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal, Karolina Michalska, Andrzej Joachimiak, Lukasz A. Joachimiak   +3 more
wiley   +1 more source

Amide Synthesis through the In Situ Generation of Chloro- and Imido-Phosphonium Salts [PDF]

, 2020
We describe a methodology for the amidation of carboxylic acids by generating phosphonium salts in situ from N-chlorophthalimide and triphenylphosphine. Aliphatic, benzylic, and aromatic carboxylic acids can be transformed into their amide counter parts ...
Floreancig, Jack T., Irving, Charles D., Laulhé, Sébastien   +2 more
core   +1 more source

Mucus Physically Restricts Influenza A Viral Particle Access to the Epithelium

Advanced Biology, Volume 9, Issue 4, April 2025.
The infectious potential of respiratory viruses depends on their ability to navigate through a layer of mucus that serves as a protective barrier in the lung. It is demonstrated that influenza A virus penetration through mucus is significantly limited by the gel's internal microstructure and, to a lesser extent, by adhesive binding to mucin glycans ...
Logan Kaler, Elizabeth M. Engle, Maria Corkran, Ethan Iverson, Allison Boboltz, Maxinne A. Ignacio, Taj Yeruva, Margaret A. Scull, Gregg A. Duncan   +8 more
wiley   +1 more source

Palladium Nanoparticle–Graphene Catalysts for Asymmetric Hydrogenation [PDF]

, 2013
We report for the first time the application of palladium nanoparticle-graphene (Pd/Gn) catalysts in the asymmetric hydrogenation of aliphatic a,b-unsaturated carboxylic acids using cinchonidine as chiral modifier. Pd/ Gns were prepared by deposition–
Bartók, Mihály, Bertóti, Imre, Puskás, Róbert, Szépvölgyi, János, Szőllősi, György, Szőri, Kornél   +5 more
core   +1 more source

Reactions of Chromyl Chloride with Carboxylic Acids and Carboxylic Acid Anhydrides

Zeitschrift für Naturforschung B, 1985
Abstract Chromyl Chloride reacts with carboxylic acids [RCOOH where R = C2H5, n-C3H7, CH2CI, CHCl2 and CCI3] to give reduced chromium(III) carboxylates, [Cr3 O(OOCR)6 (H2O)3 ]Cl. Magnetic susceptibility, UV-visible and IR measurements are all consistent with their trinuclear basic structures.
Ramesh Kapoor, Pratibha Kapoor, R. D. Sharma   +2 more
openaire   +2 more sources

Hydrogel‐Based Capacitive Sensor Model for Ammonium Monitoring in Aquaculture

Advanced Engineering Materials, EarlyView.
Traditional techniques for monitoring aquaculture water quality, particularly ammonium levels, harm fish. This work presents a novel capacitive sensor with an ionic hydrogel transducer to monitor ammonium concentration in real time based on the ammonium‐induced hydrogel dissociation and osmotic pressure. Monitoring aquaculture water quality, especially
Mohammad Mirzaee, Mahdi Askari‐sedeh, Ali Zolfagharian, Mostafa Baghani   +3 more
wiley   +1 more source