Results 61 to 70 of about 3,110 (305)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Effect of annealing process on the abnormal grain growth behavior during carburizing of 20CrMnTi steel

Materials Research Express, 2020
Abnormal grain growth (AGG) as an important physical metallurgical behavior is to be avoided during carburizing due to its adverse effect on properties such as fatigue, impact toughness and the quenching distortion.
Tao Jia, Jian Huang, Haojie Wang, Zhaodong Wang   +3 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Effect of vacuum carburizing on surface properties and microstructure of a tungsten heavy alloy

Materials Research Express, 2020
Vacuum carburizing of the R2M tungsten alloy was carried out to obtain a carburized layer that improves the surface properties. The effects of various carburizing temperatures and times on the structure and hardness were studied by Optical microscopy(OM),
Wei Li, Aiwen Li, Yilong Liang, Zhenglai Zhang, Jie Cui   +4 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Study on the Heat Treatment Process of High Strength-toughness Automobile Chain Roller

Jixie chuandong, 2016
The organization and performance of 20 CrNiMo automobile chain roller after the heat treatment of carburizing and quenching + low tempering,carburizing and quenching + medium- temperature tempering and carburizing and quenching + isothermal salt bath ...
Yang Weiming, Xing Jianheng, Lu Xudong
doaj  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Determination of Optimum Size of Rubber Fruit Shell Charcoal Powder Grain To Increase The Value of Surface Harrdness of Steel St 37 In Pack Carburizing Process

, 2017
The development of use of Pack Carburizing process to increase the value of steel surface hardness has encouraged to be conducted a research to improve the efficiency of process. One of the research conducted by Saparin (2011) by utilizing shell charcoal
Rodiawan, S.T., M.Eng.Prac., -, Edward Prawiro, -, Suhdi, -   +2 more
core  

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Experimental study of pack carburizing of carbon steel [PDF]

, 2011
The main purpose of this project is experimental study of pack carburizing of carbon steels by using two parameters (holding time and carburizing temperature). This study was conducted by using furnace.
Hazizi Azri, Ahmad Sabri
core