Results 61 to 70 of about 1,065,405 (318)

Nucleotides as an Anti‐Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study)

Advanced Science, EarlyView.
The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang, Lixia Song, Rui Fan, Qianqian Chen, Ruisheng Fu, Mei You, Yuxiao Wu, Meng Cai, Yong Li, Meihong Xu   +9 more
wiley   +1 more source

The clinical efficacy of first-generation carcinoembryonic antigen (CEACAM5)-specific CAR T cells is limited by poor persistence and transient pre-conditioning-dependent respiratory toxicity

Cancer Immunology and Immunotherapy, 2017
The primary aim of this clinical trial was to determine the feasibility of delivering first-generation CAR T cell therapy to patients with advanced, CEACAM5+ malignancy.
F. Thistlethwaite, D. Gilham, R. Guest, D. Rothwell, M. Pillai, D. Burt, A. Byatte, N. Kirillova, J. Valle, Sur Sharma, K. Chester, N. Westwood, S. Halford, S. Nabarro, S. Wan, E. Austin, R. Hawkins   +16 more
semanticscholar   +1 more source

A Promising Point‐of‐Care Testing Strategy: Ultrasmooth Gold Nanogroove Arrays Biosensor Combined with Initial Rate Analysis

Advanced Science, EarlyView.
This work reports a nanoplasmonic biosensing platform with exceptional surface sensitivity (0.618 nm nm−1, Δn = 0.117 nmol) and narrow linewidth (≈20 nm) under normal incidence. By integrating a miscellaneous‐protein strategy with initial rate analysis (IRA), this sensor can detect 1 ng mL−1 of AFP in serum with a broad linear range (1–104 ng mL−1 ...
Yi Liu, Shan Xing, Zhan Si, Kai He, Manchun Zheng, Yang Shen, Chongjun Jin   +6 more
wiley   +1 more source

Diagnostic and prognostic value of carcinoembryonic antigen in pancreatic cancer: a systematic review and meta-analysis

OncoTargets and Therapy, 2017
Background Carcinoembryonic antigen (CEA) is one of the most widely used tumor markers and is increased in 30%–60% of patients with pancreatic cancer. Although carbohydrate antigen 19-9 (CA19-9) is the most important serum biomarker in pancreatic cancer,
Qingcai Meng, S. Shi, C. Liang, Dingkong Liang, Wenyan Xu, S. Ji, Bo Zhang, Q. Ni, Jin Xu, Xianjun Yu   +9 more
semanticscholar   +1 more source

Perovskite‐Graphene Heterostructure Biosensor Integrated with Biotunable Nanoplasmonic Ternary Logic Gate for Ultrasensitive Cytokine Detection

Advanced Science, EarlyView.
This work proposes the first perovskite/graphene heterostructure‐based FET biosensor with uniquely biotunable ternary logic gating functionality for the detection of human IL6 cytokines. The biosensor integrates a lateral perovskite‐on‐graphene heterostructure phototransistor with a vertical bio‐nano‐photonic filter, achieving ultrahigh sensitivity ...
Jiaxing Sun, Lin Zhou, Zening Li, Guolin He, Hongju Mao, Jianlong Zhao, John A. Hunt, Xianfeng Chen   +7 more
wiley   +1 more source

The Carcinoembryonic Antigen (CEA): Past, Present, and Future

McGill Journal of Medicine, 2020
N ...
Phil Gold, Neil Goldberg
doaj   +1 more source

Clinical implications of carcinoembryonic antigen distribution in serum exosomal fraction—Measurement by ELISA

PLoS ONE, 2017
Background Serum exosomal proteins have great potential as indicators of disease status in cancer, inflammatory or metabolic diseases. The association of a fraction of various serum proteins such as carcinoembryonic antigen (CEA) with circulating ...
S. Yokoyama, Akihiro Takeuchi, Shunsuke Yamaguchi, Y. Mitani, Takashi Watanabe, K. Matsuda, T. Hotta, J. Shively, H. Yamaue   +8 more
semanticscholar   +1 more source

Plasmonic Molecular Entrapment for Label‐Free Methylated DNA Detection and Machine‐Learning Assisted Quantification

Advanced Science, EarlyView.
Plasmonic molecular entrapment (PME) is label‐free detection and quantification method for DNA methylation. This technique provides direct hotspot site generation around target analytes, overcoming mismatch geometrical properties. The PME demonstrates superior SERS performance and quantification capability, offering promising potential for epigenetic ...
Muhammad Shalahuddin Al Ja'farawy, Vo Thi Nhat Linh, Chaewon Mun, Jun‐Yeong Yang, Jun Young Kim, Rowoon Park, Sung‐Gyu Park, Dong‐Ho Kim, Min‐Young Lee, Ho Sang Jung   +9 more
wiley   +1 more source

The Roles of Carcinoembryonic Antigen in Liver Metastasis and Therapeutic Approaches

Gastroenterology Research and Practice, 2017
Metastasis is a highly complicated and sequential process in which primary cancer spreads to secondary organic sites. Liver is a well-known metastatic organ from colorectal cancer.
J. Lee, Seong-Wook Lee
semanticscholar   +1 more source

An MOF‐Enhanced Anti‐Fouling Immunoprobe Platform for Efficient Direct Screening of Pancreatic Cancer

Advanced Science, EarlyView.
This work introduces an electrochemical sensing method that employs an innovative platform based on metal‐organic framework (MOF) for detecting biomarkers. The platform integrates an antifouling surface, oriented antibody immobilization, and an enhanced electron transfer layer.
Wenjuan Yang, Shujuan Mao, Hao Zhu, Handong Yao, Wei Jin, Lingyan Feng, Xinghua Gao, Xuefeng Wang, Wei Chen, Min Tu, Yuan Zhang   +10 more
wiley   +1 more source