Results 71 to 80 of about 58,306 (228)

Targeting the intratumoral microbiota to overcome cancer immunotherapy resistance

Interdisciplinary Medicine, EarlyView.
This review delineates the mechanisms of intratumoral microbiota in cancer immunotherapy resistance, and offers strategies for microbiota‐targeted precision immunotherapy. Abstract Cancer remains a significant global health threat. The tumor microenvironment (TME) is a sophisticated ecological niche that exerts a pivotal effect on treatment outcomes ...
Bufu Tang, Tong Jiang, Yaling Lin, Wei Zhang, Hongjie Fan, Minjie Yang, Bingzhe Li, Yaozu Liu, Changyu Li, Xuran Jin, Wen Zhang, Zhiping Yan, Qianqian Zhao, Xuefeng Kan, Xudong Qu   +14 more
wiley   +1 more source

Potential interactions between traditional Chinese medicine and osimertinib: a Case Report

Frontiers in Pharmacology
Osimertinib, a third-generation EGFR tyrosine kinase inhibitor, played a crucial role in the treatment of EGFR-mutated non-small cell lung cancer. This case firstly reported a case of drug-drug interaction between traditional Chinese medicine (TCM) and ...
Min Zhang, Huiwen Ma, Wanyi Chen, Zhongzhen Yuan   +3 more
doaj   +1 more source

Changes of CEA Diagnostic Performance Under the New Reference Interval Stratified by Age and Sex

Journal of Clinical Laboratory Analysis, EarlyView.
Our study included patients with lung cancer, breast cancer, and colorectal cancer and apparently healthy individuals, conducted a large case–control study to assess the effects of age and sex on serum concentrations and positive rates of CEA, established age‐ and sex‐stratified reference intervals using indirect methods.
Ke Zhang, Xiarui Ye
wiley   +1 more source

The Clinicopathological Characteristics and Prognosis of Cholangiolocarcinoma: A Multicenter Study With a Central Pathology Review

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Cholangiolocarcinoma (CLC) is a rare liver cancer with ≥ 80% ductular configuration (DC). Given its rarity, its clinicopathological characteristics remain poorly understood, and its status as a distinct disease entity remains controversial.
Takamichi Ishii, Kenta Makino, Etsuro Hatano, Mina Komuta, Jun Akiba, Yoshihiro Sakamoto, Shun‐Ichi Ariizumi, Goro Honda, Toru Hisaka, Yutaka Takeda, Akira Shimizu, Kentaro Yasuchika, Takashi Mizuno, Daisuke Asano, Atsushi Fujio, Naoto Gotohda, Chie Kitami, Koji Amaya, Hiroshi Sadamori, Manabu Kawai, Akiyoshi Nakakura, Masafumi Nakamura, Itaru Endo   +22 more
wiley   +1 more source

A Novel Magnetoelastic Immunosensor for Ultrasensitively Detecting Carcinoembryonic Antigen

Nanoscale Research Letters, 2018
A novel wireless immunosensor is developed for the ultra-sensitive detection of carcinoembryonic antigen. The optimum dimension of the microchips, as magnetoelastic sensitive units, was evaluated by simulation and experiments.
Yixia Zhang, Xing Guo, Lu Fan, Qiang Zhang, Shengbo Sang   +4 more
doaj   +1 more source

Periodontitis and gastric disorders: Systematic review and meta‐analysis of functional dyspepsia and Helicobacter pylori gastritis

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis has been associated with other systemic inflammatory diseases, such as cardiovascular disease, diabetes mellitus, and rheumatoid arthritis; through the translocation of oral bacteria and local inflammatory mediators systemically.
Hadeel Mohammed Abbood, Jasim Mohammed Abbood, Ekin Yay‐Kus, Iain L. C. Chapple   +3 more
wiley   +1 more source

Prognostic Factors for Patients Under 45 Undergoing Surgery for Colorectal Liver Metastases: A SEER Population‐Based Study

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives Colorectal cancer (CRC) has been on the rise in adults younger than 50. Surgical resection is a potentially curative treatment option for patients with colorectal liver metastases (CRLM). The aim of this study was to describe patient and tumor characteristics associated with disease‐specific survival in young patients
Gabrielle Grob, Fang Fang, Matvey Karpov, Eric Feliberti, Marybeth Hughes, Rachel Burke, Winifred Lo   +6 more
wiley   +1 more source

Proteomics‐Based Identification of the Pyroptosis‐Related Biomarker PCSK9 and Its Association With the Pathogenesis of Rheumatoid Arthritis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Rheumatoid arthritis (RA) is a common autoimmune disease, and early diagnosis is critical for effective treatment. This study aims to identify potential biomarkers related to pyroptosis through serum proteomics analysis, offering new insights for the early diagnosis of RA.
Lei Wang, Hao‐Jie Chen, Ting‐Ting Wu, Xin‐Yi Shen, Ying‐Ying Gao, Yu‐Feng Yin, Tian Ren, Xin Chu, Jing Cao, Tao Cheng, Ming‐Jun Wang   +10 more
wiley   +1 more source

Integrating CT‐Based Radiomics Analysis With Serum CEA Level to Predict Neoadjuvant Chemoradiotherapy Response in Colorectal Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Response to neoadjuvant chemoradiotherapy (NACRT) in locally advanced colorectal cancer (CRC) varies widely, and accurately identifying poor responders is crucial for guiding timely treatment modification. This study aimed to develop an integrated predictive model combining radiomics derived from routine radiotherapy non‐contrast planning ...
Sin‐Hua Moi, Ming‐Yii Huang, Shu‐Han Yang, Chien‐Jang Chen, Ying‐Pei Jhong, Tun‐Wei Hsu, Chien‐Chih Ke   +6 more
wiley   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source