Results 71 to 80 of about 308,405 (401)

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

open access: yesMolecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka   +10 more
wiley   +1 more source

Scientific Ignorance and Reliable Patterns of Evidence in Toxic Tort Causation: Is There a Need for Liability Reform? [PDF]

open access: yes, 2001
As a first step to preserving the central aims of tort law, courts will need to recognize the wide variety of respectable, reliable patterns of evidence on which scientists themselves rely for drawing inferences about the toxicity of substances.
Cranor, Carl F., Eastmond, David A.
core   +2 more sources

PP2A Deficiency Enhances Carcinogenesis of Lgr5+ Intestinal Stem Cells Both in Organoids and In Vivo

open access: yesCells, 2019
In most cancers, cellular origin and the contribution of intrinsic and extrinsic factors toward transformation remain elusive. Cell specific carcinogenesis models are currently unavailable. To investigate cellular origin in carcinogenesis, we developed a
Yu-Ting Yen   +6 more
doaj   +1 more source

The Influence of Electromagnetic Field Pollution on Human Health: A Systematic Review

open access: yesSiriraj Medical Journal, 2021
Objective: Recent technological advances have exponentially expanded globally; harbouring upon Electromagnetic fields (EMF). The utilization of Electromagnetic field has become universal from everyday usage of electronic appliances such as micro wave ...
Monalisha Sahu   +2 more
doaj   +1 more source

The State of Middle School and High School Science Labs in the Kansas City Region [PDF]

open access: yes, 2007
Shares findings from an audit of 170 school science labs, and makes recommendations for improvement in the areas of safety, facilities, equipment and materials, instruction and learning, and district ...

core  

Polyethylene glycol, unique among laxatives, suppresses aberrant crypt foci, by elimination of cells. [PDF]

open access: yes, 2006
OBJECTIVE: Polyethylene glycol (PEG), an osmotic laxative, is a potent inhibitor of colon cancer in rats. In a search for the underling mechanisms, the hypothesis that fecal bulking and moisture decrease colon carcinogenesis was tested.
Corpet, Denis E.   +3 more
core   +2 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Sex differences in lymphoma incidence and mortality by subtype: A population‐based study

open access: yesAmerican Journal of Hematology, Volume 98, Issue 1, Page 23-30, January 2023., 2023
A higher incidence and a trend toward higher mortality in men for most lymphoma subtypes is seen in this Swedish population‐based cohort study on adults (age 18‐99) diagnosed with lymphoma 2000‐2019. Male‐to‐female incidence rate ratio (IRR) by male‐to‐female excess mortality ratio (EMR), both adjusted for age and year of diagnosis, by lymphoma subtype.
Cecilia Radkiewicz   +9 more
wiley   +1 more source

Review of trace toxic elements (Pb, Cd, Hg, As, Sb, Bi, Se, Te) and their deportment in gold processing. Part 1: Mineralogy, aqueous chemistry and toxicity [PDF]

open access: yes, 2011
A literature review on the deportment of trace toxic elements (Pb, Cd, Hg, As, Sb, Bi, Se, and Te) in gold processing by cyanidation is presented which compiles the current knowledge in this area and highlights the gaps.
Breuer, P.L.   +4 more
core   +2 more sources

Head and neck squamous cell carcinoma

open access: yesNature Reviews Disease Primers, 2020
Head and neck squamous cell carcinomas (HNSCCs) originate from the mucosal epithelium in the oral cavity, pharynx and larynx, and are caused by viral infection or carcinogen exposure.

semanticscholar   +1 more source

Home - About - Disclaimer - Privacy