Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka+10 more
wiley +1 more source
Scientific Ignorance and Reliable Patterns of Evidence in Toxic Tort Causation: Is There a Need for Liability Reform? [PDF]
As a first step to preserving the central aims of tort law, courts will need to recognize the wide variety of respectable, reliable patterns of evidence on which scientists themselves rely for drawing inferences about the toxicity of substances.
Cranor, Carl F., Eastmond, David A.
core +2 more sources
PP2A Deficiency Enhances Carcinogenesis of Lgr5+ Intestinal Stem Cells Both in Organoids and In Vivo
In most cancers, cellular origin and the contribution of intrinsic and extrinsic factors toward transformation remain elusive. Cell specific carcinogenesis models are currently unavailable. To investigate cellular origin in carcinogenesis, we developed a
Yu-Ting Yen+6 more
doaj +1 more source
The Influence of Electromagnetic Field Pollution on Human Health: A Systematic Review
Objective: Recent technological advances have exponentially expanded globally; harbouring upon Electromagnetic fields (EMF). The utilization of Electromagnetic field has become universal from everyday usage of electronic appliances such as micro wave ...
Monalisha Sahu+2 more
doaj +1 more source
The State of Middle School and High School Science Labs in the Kansas City Region [PDF]
Shares findings from an audit of 170 school science labs, and makes recommendations for improvement in the areas of safety, facilities, equipment and materials, instruction and learning, and district ...
core
Polyethylene glycol, unique among laxatives, suppresses aberrant crypt foci, by elimination of cells. [PDF]
OBJECTIVE: Polyethylene glycol (PEG), an osmotic laxative, is a potent inhibitor of colon cancer in rats. In a search for the underling mechanisms, the hypothesis that fecal bulking and moisture decrease colon carcinogenesis was tested.
Corpet, Denis E.+3 more
core +2 more sources
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani+14 more
wiley +1 more source
Sex differences in lymphoma incidence and mortality by subtype: A population‐based study
A higher incidence and a trend toward higher mortality in men for most lymphoma subtypes is seen in this Swedish population‐based cohort study on adults (age 18‐99) diagnosed with lymphoma 2000‐2019. Male‐to‐female incidence rate ratio (IRR) by male‐to‐female excess mortality ratio (EMR), both adjusted for age and year of diagnosis, by lymphoma subtype.
Cecilia Radkiewicz+9 more
wiley +1 more source
Review of trace toxic elements (Pb, Cd, Hg, As, Sb, Bi, Se, Te) and their deportment in gold processing. Part 1: Mineralogy, aqueous chemistry and toxicity [PDF]
A literature review on the deportment of trace toxic elements (Pb, Cd, Hg, As, Sb, Bi, Se, and Te) in gold processing by cyanidation is presented which compiles the current knowledge in this area and highlights the gaps.
Breuer, P.L.+4 more
core +2 more sources
Head and neck squamous cell carcinoma
Head and neck squamous cell carcinomas (HNSCCs) originate from the mucosal epithelium in the oral cavity, pharynx and larynx, and are caused by viral infection or carcinogen exposure.
semanticscholar +1 more source