Results 81 to 90 of about 77,097 (309)

Occupational exposure to chromium(VI) compounds

Medycyna Pracy, 2015
This article discusses the effect of chromium(VI) (Cr(VI)) on human health under conditions of acute and chronic exposure in the workplace. Chromium(VI) compounds as carcinogens and/or mutagens pose a direct danger to people exposed to them.
Jolanta Skowroń, Katarzyna Konieczko
doaj   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

RBM10 Deficiency Promotes Anti‐PD‐1 Resistance in LUAD via STING Alternative Splicing‐Driven CCL7 Signaling and Macrophage Polarization

Advanced Science, EarlyView.
RBM10 deficiency promotes anti‐PD‐1 resistance in lung adenocarcinoma by altering STING alternative splicing, which enhances CCL7 secretion and CCR2‐dependent M2 macrophage polarization. A positive feedback loop via mitochondrial transfer sustains this immunosuppression.
Weitong Gao, Ruqiong Wang, Bo An, Lishuang Qi, Zihan Jing, Xingmei Ren, Yang Zhou, Mingjun Xu, Jiaojiao Li, Jie Liu, Liying Wang, Gang Xu, Rou Li, Dexin Jia, Yan Yu   +14 more
wiley   +1 more source

Candida in potentially malignant oral disorders

Journal of Pharmacy and Bioallied Sciences, 2015
Oro-pharyngeal cancer is a significant component in the global burden of cancer. A considerable proportion of oral squamous carcinomas develop from preexsiting potentially malignant disorder of the oral cavity.
S Leena Sankari, K Gayathri, N Balachander, L Malathi   +3 more
doaj   +1 more source

Carcinogenicity of chloroform. [PDF]

Environmental Health Perspectives, 1979
Chloroform is carcinogenic in rats, mice, and probably in dogs. Chloroform induced carcinomas of the liver and kidney and malignant tumors in other organs in rats and mice. Liver neoplasms have been described in three strains of mice. Carcinomas of the kidney were found in a first study in mice and in the repeat of that study.
openaire   +2 more sources

Carcinogen-modified dendritic cells induce immunosuppression by incomplete T-cell activation resulting from impaired antigen uptake and reduced CD86 expression

, 2000
Exposure of the skin to environmental stimuli, such as chemical or physical carcinogens, modifies the local skin environment, including depletion of epidermal Langerhans' cells (LC).
Gregory Woods (14753302), Kathleen Doherty (14735404), Muller, HK (15477911), Roslyn Malley (14743228), Rist, MJ (15486611)   +4 more
core  

ML Workflows for Screening Degradation‐Relevant Properties of Forever Chemicals

Advanced Science, EarlyView.
The environmental persistence of per‐ and polyfluoroalkyl substances (PFAS) necessitates efficient remediation strategies. This study presents physics‐informed machine learning workflows that accurately predict critical degradation properties, including bond dissociation energies and polarizability.
Pranoy Ray, Andrew R. Castillo, Manoj Kolel‐Veetil, Surya R. Kalidindi   +3 more
wiley   +1 more source

Myricetin stimulates the absorption of the pro-carcinogen PhIP

, 2006
The effect of the flavonoid myricetin on the transport of the pro-carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through differentiated Caco-2 monolayers, a model for the intestinal epithelium, is described.
Alink, G.M., Schutte, M.E., Rietjens, I.M.C.M., Groten, J.P., Sandt, J.J.M., van de   +4 more
core   +2 more sources

Hygiene and legal aspects of occupational exposure assessment to cytostatics

Medycyna Pracy, 2018
The employers responsibilities for the assessment of occupational exposure to cytostatics in the workplace were analyzed in the light of existing legal regulations.
Małgorzata Kupczewska-Dobecka, Anna Pałaszewska-Tkacz, Sławomir Czerczak, Katarzyna Konieczko   +3 more
doaj   +1 more source

Tobacco carcinogen NNK promotes pancreatic cancer proliferation via LINC00857/β-catenin

Introduction Smoking is a key risk factor for pancreatic cancer (PC). Nicotinederived nitrosamine ketone (NNK), a major tobacco smoke constituent, has been shown to promote cancer growth, but its specific role in PC progression remains unclear.
Ruiqi Cao, Zheng Wang, Qingyong Ma, Shengzhan Zhang, Jie Hao, Weikun Qian, Zheng Wu, Qiqi Wang, Jiantao Mo, Xin Chen, Cancan Zhou, Zhengyuan Feng   +11 more
core   +1 more source