Results 71 to 80 of about 63,809 (265)

Strategies for inducing diabetes in laboratory animals: Advances from chemical, surgical, immunologic, dietary, and genetic approaches

Animal Models and Experimental Medicine, EarlyView.
This review summarizes the principal experimental approaches used to induce diabetes in animal models. Strategies include chemical agents (streptozotocin, alloxan, dithizone, gold thioglucose), dietary interventions (high‐fat and high‐sugar diets), surgical methods (total or partial pancreatectomy), genetic models (db/db, ob/ob, Goto‐Kakizaki [GK ...
Milad Faraji, Maedeh Faraji, Nasrin Kazemipour   +2 more
wiley   +1 more source

Pteridium aquilinum (L.) Kuhn—A Review of Its Toxicology, Pharmacology, and Phytochemistry

Plants
Pteridium aquilinum (L.) Kuhn, known as bracken fern, is considered a poisonous plant due to its toxic substances. This species contains toxic substances and enzymes: thiaminase and an anti-thiamine substance, which cause thiamine deficiency syndrome ...
Hisashi Kato-Noguchi, Midori Kato
doaj   +1 more source

Formulation and evaluation of sustained release matrix tablet of rabeprazole using wet granulation technique

Journal of Pharmacy and Bioallied Sciences, 2014
Introduction: Rabeprazole, a member of substituted benzimidazoles, inhibits the final step in gastric acid secretions. This drug claims to cause fastest acid separation (due to higher pKa), and more rapidly converts to the active species to aid gastric ...
Ruqaiyah Khan, Md Shamim Ashraf, Muhammad Afzal, Imran Kazmi, Mohammed Asadullah Jahangir, Rajbala Singh, Ramesh Chandra, Firoz Anwar   +7 more
doaj   +1 more source

Comparative analysis of TP53 gene in Tupaia belangeri subspecies (Tupaia belangeri yaoshanensis vs. Tupaia belangeri chinensis) and identification of mutations in spontaneous tumor cases

Animal Models and Experimental Medicine, EarlyView.
This study provides the first evidence of natural TP53 variation between tree shrew subspecies and identifies somatic TP53 mutations in spontaneous tree shrew sarcomas. The high structural and functional conservation of tree shrew p53 with humans supports its utility as a relevant model for TP53‐related cancer research.
Yingying Cao, Haibo Tang, Liang Liang, Jing Leng, Weijian Huang   +4 more
wiley   +1 more source

Health Damage and Repair Mechanism Related to Formaldehyde Released from Wood-based Panels

BioResources, 2023
Wood-based panels, which contain wood raw materials along with urea-formaldehyde (UF) or phenol-formaldehyde (PF) resins, can increase the indoor air concentration of formaldehyde. Formaldehyde can stimulate the upper respiratory mucosa and cross-linking
Fan Gao, Xiaohen Yue, Hongqi Yang, Yafeng Yang, Su Shiung Lam, Wanxi Peng, Xiangmeng Chen   +6 more
doaj   +2 more sources

TRAFFIC - RELATED CONCENTRATIONS OF BTEX, FORMALDEHYDE AND ACETALDEHYDE IN TEHRAN; CONCENTRATIONS AND SPATIAL VARIABILITY

Journal of Air Pollution and Health, 2018
Introduction: Traffic and mobile sources are possibly responsible to the most of the ambient volatile organic compounds (VOCs) in urban areas.
Mostafa Hadei, Abbas Shahsavani, Majid Kermani, Baharan Emam, Maryam Yarahmadi, Reza Bakhtiari   +5 more
doaj  

Safety and Feasibility of Magnetic Separation‐Based Blood Purification

Advanced NanoBiomed Research, EarlyView.
We present the preclinical biological safety and translational feasibility of a magnetic nanoparticle‐based extracorporeal blood purification platform for removal of disease‐causing blood factors. ISO 10993‐compliant studies and exaggerated worst‐case exposure models demonstrate efficient nanoparticle extraction (≥99.9%), favorable biocompatibility ...
Carlos A. Mora, Laurine Rijsbergen, Jan Waskowski, Gaelle Clermont, Florian Dingreville, Chandrashekara Vishwanath, Rajesh Karunanithi, Alexander Gogos, Jean‐Claude Metzger, Manuel Baumgartner, Joerg C. Schefold, Inge K. Herrmann   +11 more
wiley   +1 more source

Beyond Blast Injury: Occupational Hygiene, Safety, and Toxicology Considerations for Mixed-Metal and Energetic-Chemical Exposures to Explosive Ordnance Disposal Personnel

Toxics
Explosive ordnance (EO), including AXO (abandoned explosive ordnance), IEDs (improvised explosives devices), and UXO (unexploded ordnance), are widely recognised for their blast and fragmentation hazards, but they also represent a persistent and under ...
Bryan G. Fry, Kelly Johnstone, Stacey Pizzino   +2 more
doaj   +1 more source

Unrecognized risks of nickel-related respiratory cancer among Canadian electrolysis workers

Scandinavian Journal of Work, Environment & Health, 2012
OBJECTIVES: Nickel compounds, inclusive of water-soluble salts, have been classified as human carcinogens by the International Agency for Research on Cancer (IARC).
Tom K Grimsrud, Aage Andersen
doaj   +1 more source

Nicotine: carcinogenicity and effects on response to cancer treatment – A review

Frontiers in Oncology, 2015
Tobacco use is considered the single most important man-made cause of cancer that can be avoided. The evidence that nicotine is involved in cancer development is reviewed and discussed in this paper.
Tore eSanner, Tom K eGrimsrud
doaj   +1 more source