Results 81 to 90 of about 238,323 (340)
An integrated in vitro carcinogenicity test that distinguishes between genotoxic carcinogens, non-genotoxic carcinogens, and non-carcinogens [PDF]
MutagenesisAbstract Chemical safety testing plays a crucial role in product and pharmacological development, as well as chemoprevention; however, in vitro genotoxicity safety tests do not always accurately predict the chemicals that will be in vivo carcinogens.
Katherine E Chapman +5 more
openaire +3 more sources
Advanced Sustainable Systems, EarlyView.This study evaluates the environmental trade‐offs of different rice husk management strategies using a life cycle assessment (LCA) approach. It compares biochar production for water treatment and soil improvement with direct incineration for energy generation.
José Lugo‐Arias +7 more
wiley +1 more source
Advanced Science, EarlyView.Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu +7 more
wiley +1 more source
The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges
Advanced Science, EarlyView.This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li +3 more
wiley +1 more source
Population health risk related to increased content of benzpyrene in soil
Analiz Riska Zdorovʹû, 2017 The article deals with the problem of soil contamination with benzpyrene within sanitary-hygienic zone of an oil refinery plant. We proved that benzpyrene penetrated into soils due to oil-containing wastes and sedimentation of polycyclic aromatic ...
V.V. Suchkov +5 more
doaj +1 more source
Advanced Science, EarlyView.Lung squamous cell carcinoma (LUSC) is often preceded by sequential premalignant lesions with an increasing probability of malignant progression. Using single‐cell RNA sequencing, the dynamic cellular evolution from normal lung to LUSC tissues is delineated; clonal structure of premalignant and malignant epithelium is reveled; the conversion of immune ...
Baohong Luo +16 more
wiley +1 more source
Tobacco carcinogen research to aid understanding of cancer risk and influence policy
Laryngoscope Investigative Otolaryngology, 2018 Education regarding the health effects associated with tobacco use has made important progress worldwide over the last few decades. Still, tobacco remains a significant cause of cancer and other diseases.
Hitesh Singhavi +6 more
doaj +1 more source
Advanced Science, EarlyView.Identifying biomarkers associated with PTC, particularly those related to PTMC progression, is crucial for precise risk stratification and treatment planning. This study utilized single‐cell RNA sequencing on 19 surgical tissue specimens, confirmed PROS1/MERTK axis as a critical component of the cellular microenvironment and a key regulatory mechanism ...
Wenqian Zhang +11 more
wiley +1 more source
Advanced Science, EarlyView.The bottom‐up strategy based on multiomics data is used for the SynCom design, and it successfully inhibited F. nucleatum growth and achieved stable colonization in vivo. In addition, it promoted tryptophan metabolism and secondary bile acid conversion, reduced lipid accumulation, relieved microbiome disorder, decreased inflammatory reaction, and ...
Zhongkun Zhou +11 more
wiley +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 1984 We have examined the distribution of individual adducts in repetitive DNA sequences of rat liver in vivo after a single dose of the carcinogen N-hydroxy-2-acetyl-aminofluorene.
R. Gupta
semanticscholar +1 more source