Results 151 to 160 of about 650,641 (407)
Electric Transport Properties of the p53 Gene and the Effects of Point Mutations [PDF]
arXiv, 2007 In this work, charge transport (CT) properties of the p53 gene are numerically studied by the transfer matrix method, and using either single or double strand effective tight-binding models. A statistical analysis of the consequences of known p53 point mutations on CT features is performed. It is found that in contrast to other kind of mutation defects,
arxiv
Advanced Science, EarlyView.Mesoporous gold nanospheres confined platinum nanoclusters (MGNSs@Pt) is developed as robust hydroxyl radical and oxygen nanogenerators for multimodal therapies. Their NIR‐II LSPR property also allowed MGSNs to be ideal phototheranostic agents. The chemodynamic and photothermal therapy efficiently induced the tumor cell apoptosis, enabling the MGNSs@Pt
Fei Cun +7 more
wiley +1 more source
BMC Infectious Diseases, 2017 Background Epstein Barr virus (EBV) plays a causal role in some diseases, including infectious mononucleosis, lymphoproliferative diseases and nasopharyngeal carcinoma.
Pengfei Cao +9 more
doaj +1 more source
Statistical Approaches for Modelling Cancer Bioassays [PDF]
arXiv, 2013 This paper discusses the possible ways to analyse the data, adopting a matrix notation, so often used in Bioassays. The paper also reviews the Multistage Models (MM). The MM class of models is applied for extrapolation, to the region of Low-Dose. The effect of covariates in experimental carcinogenesis is introduced and the relative efficiency is ...
arxiv
Advanced Science, EarlyView.CXCL6's function in cholangiocarcinoma is underexplored. Here it is discovered that CXCL6 is upregulated in cholangiocarcinoma tissues and promotes proliferation and metastasis of it. CXCL6 functions through the CXCR1/2‐JAK‐STAT/PI3K axis and reshaping tumor lipid metabolism.
Tian He +15 more
wiley +1 more source
Advanced Science, EarlyView.Plasmonic molecular entrapment (PME) is label‐free detection and quantification method for DNA methylation. This technique provides direct hotspot site generation around target analytes, overcoming mismatch geometrical properties. The PME demonstrates superior SERS performance and quantification capability, offering promising potential for epigenetic ...
Muhammad Shalahuddin Al Ja'farawy +9 more
wiley +1 more source
Correlated fragile site expression allows the identification of candidate fragile genes involved in immunity and associated with carcinogenesis [PDF]
BMC Bioinformatics 2006, 7:413, 2006 Common fragile sites (cfs) are specific regions in the human genome that are particularly prone to genomic instability under conditions of replicative stress. Several investigations support the view that common fragile sites play a role in carcinogenesis.
arxiv
Advanced Science, EarlyView.During the G2/M phase, mucin1 (MUC1) activates protein phosphatase 2A (PP2A), leading to reduced phosphorylation of protein kinase C ζ (PKCζ) and NUMB, which promotes symmetric division and expansion of cancer stem‐like cells (CSLCs), thereby driving tumorigenesis. Combined inhibition of the MUC1–PP2A axis using LB100/GO203 with etoposide restores PKCζ
Shengze Li +15 more
wiley +1 more source