Results 261 to 270 of about 650,641 (407)

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Retraction: Downregulation of long non-coding RNA ANRIL suppresses lymphangiogenesis and lymphatic metastasis in colorectal cancer. [PDF]

Oncotarget
Sun Z, Ou C, Ren W, Xie X, Li X, Li G.
europepmc   +1 more source

An Experimental Study of the Pathological Effects of Cigarette Condensate in the Lungs with Special Reference to Carcinogenesis

, 1961
J. W. S. Blacklock
openalex   +2 more sources

Summary of the discussion on mammary carcinogenesis in the rat [PDF]

, 1982
Broerse, J. J., Gerber, G. B., Kellerer, Albrecht M.   +2 more
core   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

RETRACTED: Rehman et al. Piperine Regulates Nrf-2/Keap-1 Signalling and Exhibits Anticancer Effect in Experimental Colon Carcinogenesis in Wistar Rats. <i>Biology</i> 2020, <i>9</i>, 302. [PDF]

Biology (Basel)
Rehman MU, Rashid S, Arafah A, Qamar W, Alsaffar RM, Ahmad A, Almatroudi NM, Alqahtani SMA, Rashid SM, Ahmad SB.   +9 more
europepmc   +1 more source

FINE STRUCTURAL ALTERATIONS IN CELL PARTICLES DURING CHEMICAL CARCINOGENESIS [PDF]

, 1961
Joseph C. Arcos, Hans H. Gosch, David Zickafoose   +2 more
openalex   +1 more source

Outcome of IWGT workshop on transcriptomic biomarkers for genotoxicity: Key considerations for bioinformatics

Environmental and Molecular Mutagenesis, EarlyView.
Abstract As a part of the International Workshop on Genotoxicity Testing (IWGT) in 2022, a workgroup was formed to evaluate the level of validation and regulatory acceptance of transcriptomic biomarkers that identify genotoxic substances. Several such biomarkers have been developed using various molecular techniques and computational approaches. Within
Matthew J. Meier, Florian Caiment, J. Christopher Corton, Roland Frötschl, Yurika Fujita, Danyel Jennen, Roman Mezencev, Carole Yauk   +7 more
wiley   +1 more source

Inflammation-Associated Carcinogenesis in Inflammatory Bowel Disease: Clinical Features and Molecular Mechanisms. [PDF]

Cells
Hisamatsu T, Miyoshi J, Oguri N, Morikubo H, Saito D, Hayashi A, Omori T, Matsuura M.   +7 more
europepmc   +1 more source

MECHANISM OF VIRAL CARCINOGENESIS BY DNA MAMMALIAN VIRUSES, II. VIRAL-SPECIFIC RNA IN TUMOR CELLS INDUCED BY “WEAKLY” ONCOGENIC HUMAN ADENOVIRUSES

, 1967
Kei Fujinaga, Maurice Green
openalex   +1 more source