Results 1 to 10 of about 230,259 (343)

Carcinogenicity of occupational exposure as a firefighter.

The Lancet Oncology, 2022
www.thelancet.com/oncology Published online June 30, 2022 https://doi.org/10.1016/S1470-2045(22)00390-4 1 In June, 2022, 25 scientists from eight countries met at the International Agency for Research on Cancer (IARC) in Lyon, France, to finalise their ...
P. Demers, D. DeMarini, K. Fent, D. Glass, J. Hansen, Olorunfemi Adetona, M. H. Andersen, Laura E. Beane Freeman, A. Caban-Martinez, R. Daniels, T. Driscoll, J. Goodrich, J. Graber, T. Kirkham, K. Kjaerheim, D. Kriebel, A. Long, L. Main, M. Oliveira, S. Peters, L. Teras, E. Watkins, J. Burgess, A. Stec, Paul A. White, N. DeBono, L. Benbrahim-Tallaa, A. de Conti, F. el Ghissassi, Y. Grosse, L. Stayner, E. Suonio, S. Viegas, R. Wedekind, P. Boucheron, B. Hosseini, Joanne Kim, H. Zahed, Heidi Mattock, F. Madia, M. Schubauer-Berigan   +40 more
semanticscholar   +3 more sources

DCAMCP: A Deep Learning Model Based on Capsule Network and Attention Mechanism for Molecular Carcinogenicity Prediction

Journal of Cellular and Molecular Medicine, 2023
The carcinogenicity of drugs can have a serious impact on human health, so carcinogenicity testing of new compounds is very necessary before being put on the market.
Qi Zhao, Shuaidong Yin, Jianqiang Sun
exaly   +2 more sources

Integrative network toxicology and molecular docking reveal epigenetic and endocrine-disrupting mechanisms of PFAS in ovarian cancer [PDF]

Frontiers in Pharmacology
ObjectivePer- and polyfluoroalkyl substances (PFAS) are omnipresent, persistent contaminants associated with rising ovarian cancer incidence; however, the molecular circuitry linking PFAS to ovarian tumorigenesis remains obscure.MethodsHere, an ...
Yulu Wang, Xueli Liu, Yanan Ding, Zhanjie Zhao, Haotian Chen, Haotian Chen, Xiaojuan Wu, Xiaojuan Wu, Yanzhou Yang, Pengge Pan, Luyi Li, Luyi Li, Hui Gao   +12 more
doaj   +2 more sources

Dose–Response Relationships for Lung Tumor and Pleural Mesothelioma Induction by Repetitive Intratracheal Instillation of a Multiwalled Carbon Nanotube, MWCNT-7, in Rats: Comparison with Inhalation Carcinogenicity Based on Lung Burden [PDF]

Nanomaterials
The multiwalled carbon nanotube, MWCNT-7, is carcinogenic to rat lungs when inhaled over the course of 2 years, but does not induce pleural mesothelioma. In contrast, intratracheal instillation of MWCNT-7 causes both lung tumors and pleural mesotheliomas.
Ai Maeno, Motoki Hojo, Yoshimitsu Sakamoto, Yukio Yamamoto, Kiyomi Ikushima, Kai Igarashi, Satoshi Yokota, Yuhji Taquahashi, Norihiro Kobayashi, Hiroyuki Tsuda, Aya Naiki-Ito, Takamasa Numano, Jun Kanno, Akihiko Hirose, Akiko Inomata, Junichi Kamiie, Dai Nakae   +16 more
doaj   +2 more sources

Ni(II) Ions May Target the Entire Melatonin Biosynthesis Pathway—A Plausible Mechanism of Nickel Toxicity

Molecules, 2022
Nickel is toxic to humans. Its compounds are carcinogenic. Furthermore, nickel allergy is a severe health problem that affects approximately 10–20% of humans.
Nina E. Wezynfeld, Arkadiusz M. Bonna, Dawid Płonka, Wojciech Bal, Tomasz Frączyk   +4 more
doaj   +1 more source

Human papillomavirus genomics: Understanding carcinogenicity.

Tumour Virus Research, 2023
Human papillomavirus (HPV) causes virtually all cervical cancers and many cancers at other anatomical sites in both men and women. However, only 12 of 448 known HPV types are currently classified as carcinogens, and even the most carcinogenic type ...
Chase W. Nelson, L. Mirabello
semanticscholar   +1 more source

Assessment of Systemic Toxicity, Genotoxicity, and Early Phase Hepatocarcinogenicity of Iron (III)-Tannic Acid Nanoparticles in Rats

Nanomaterials, 2022
Iron-tannic acid nanoparticles (Fe-TA NPs) presented MRI contrast enhancement in both liver cancer cells and preneoplastic rat livers, while also exhibiting an anti-proliferative effect via enhanced autophagic death of liver cancer cells.
Chi Be Hlaing, Arpamas Chariyakornkul, Chalermchai Pilapong, Charatda Punvittayagul, Somdet Srichairatanakool, Rawiwan Wongpoomchai   +5 more
doaj   +1 more source

Insights into the potential carcinogenicity of micro- and nano-plastics.

Mutation research. Reviews in mutation research, 2023
There is a growing concern regarding the potential health effects that continuous exposure to environmental micro- and nano-plastics (MNPLs) may cause on humans. Due to their persistent nature, MNPLs may accumulate in different organs and tissues and may
J. Domenech, B. Annangi, R. Marcos, Alba Hernández, J. Catalán   +4 more
semanticscholar   +1 more source

Cadmium, carcinogen, co-carcinogen and anti carcinogen [PDF]

Indian Journal of Clinical Biochemistry, 2001
As a stress agent, inducing apoptosis and blocking it, Cd can have both helpful and harmful effects. The atmosphere is a thin envelope which makes the worid a global village. Cd is the most toxic metal in air. As both the first and second messenger of the stress response, it is synergistically toxic with all other stressors, including many other ...
R, Chandra, S K, Dass, P, Tomar, M, Tiwari   +3 more
openaire   +2 more sources

Toxicological Properties of 7-Methylguanine, and Preliminary Data on its Anticancer Activity

Frontiers in Pharmacology, 2022
7-Methylguanine (7-MG) competitively inhibits the DNA repair enzyme poly(ADP-ribose) polymerase (PARP) and RNA-modifying enzyme tRNA-guanine transglycosylase (TGT) and represents a potential anticancer drug candidate.
Kirill Kirsanov, Kirill Kirsanov, Timur Fetisov, Elena Antoshina, Lubov Trukhanova, Tatiana Gor’kova, Olga Vlasova, Irina Khitrovo, Ekaterina Lesovaya, Ekaterina Lesovaya, Nataliya Kulbachevskaya, Tatiana Shcherbakova, Gennady Belitsky, Marianna Yakubovskaya, Vytas Švedas, Vytas Švedas, Dmitry Nilov   +16 more
doaj   +1 more source