Results 91 to 100 of about 352,926 (358)

Summary of Workshop to Review an OMB Report on Regulatory Risk Assessment and Management [PDF]

open access: yes, 1992
Summary of the results of an invitational workshop conducted to peer review the 1990 OMB report, CURRENT REGULATORY ISSUES IN Risk ASSESSMENT AND Risk MANAGENMENTIN REGULATORY PROGRAM OF THE UNITED STATES GOVERNMENT, APRIL 1, 1990 - MARCH 31 ...
Evans, John S.   +3 more
core   +2 more sources

Geochemistry and risk assessment of street dust in Luanda, Angola, a tropical urban environment [PDF]

open access: yes, 2005
A total of 92 samples of street dust were collected in Luanda, Angola, were sieved below 100 μm, and analysed by ICP-MS for 35 elements after an aqua-regia digestion.
Ferreira Baptista, Lopes   +1 more
core   +2 more sources

Tailoring a Functional Synthetic Microbial Community Alleviates Fusobacterium nucleatum‐infected Colorectal Cancer via Ecological Control

open access: yesAdvanced Science, EarlyView.
The bottom‐up strategy based on multiomics data is used for the SynCom design, and it successfully inhibited F. nucleatum growth and achieved stable colonization in vivo. In addition, it promoted tryptophan metabolism and secondary bile acid conversion, reduced lipid accumulation, relieved microbiome disorder, decreased inflammatory reaction, and ...
Zhongkun Zhou   +11 more
wiley   +1 more source

Health effects of exposure to static magnetic field − a review of literature

open access: yesMedycyna Pracy, 2019
The authors discuss the effects of static magnetic field (SMF) exposure based on reviewed literature reports. The systematic review covered both research carried out directly with people as well as studies with animals.
Marek Zmyślony, Piotr Politański
doaj   +1 more source

Evaluation of polycyclic aromatic hydrocarbons using analytical methods, toxicology, and risk assessment research: seafood safety after a petroleum spill as an example. [PDF]

open access: yes, 2014
BackgroundPolycyclic aromatic hydrocarbons (PAHs) are abundant and widespread environmental chemicals. They are produced naturally and through man-made processes, and they are common in organic media, including petroleum.
Ansari, Shakeel   +15 more
core   +1 more source

POLE Deficiency Exacerbates Diesel Engine Exhaust‐Induced Genomic Instability and Malignant Transformation of Bronchial Epithelial Cells

open access: yesAdvanced Science, EarlyView.
This study establishes a diesel engine exhaust (DEE)‐induced malignant transformation model in bronchial epithelial cells. Whole genome sequencing(WGS) and RNA‐seq reveal DEE‐induced mutational signatures and gene expression profiles. Mechanistically, DEEaffect polymerase epsilon (POLE) and mismatch repair, driving genomic instability and promoting ...
Pimei Zhang   +8 more
wiley   +1 more source

Bacterial reduction of N-oxides of tobacco- specific nitrosamines (TSNA) [PDF]

open access: yes, 1996
1 Contrary to established metabolic pattern, a recent investigation of NNK metabolism produced in rat urine higher levels of 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone (NNK) and 4-(methylnitrosamino)-1-(3-pyri dyl)-1-butanol (NNAL) than their N ...
Calmels S.   +4 more
core   +1 more source

Scaffolding Protein ENH Promotes Tumor Angiogenesis and Growth Through Macrophage Recruitment and Polarization

open access: yesAdvanced Science, EarlyView.
In tumor cells, ENH prompts the interaction between YAP and KPNA2. This interaction enables YAP to translocate into the nucleus, where it enhances the transcription of CCL5. Consequently, this up‐regulation of CCL5 drives the infiltration of tumor‐associated macrophages (TAMs) and their polarization toward the M2 phenotype, ultimately facilitating ...
Yueli Shi   +14 more
wiley   +1 more source

Plasma DNMT1 Activity for Assessing Tumor Burden and Predicting Neoadjuvant Therapy Response in Breast Cancer

open access: yesAdvanced Science, EarlyView.
In this work, a detection method is presented for the activity of plasma DNA methyltransferase 1 (DNMT1), namely DNMT1 Identification by Variable Activity (DIVA). DIVA can detect plasma DNMT1 at levels as low as 10−7 U mL−1, also it successfully evaluated tumor burden and predicted the neoadjuvant therapy responses of breast cancer patients.
Yingran Wang   +10 more
wiley   +1 more source

Redressing the Silent Interim: Precautionary Action & Short Term Tests in Toxicological Risk Assessment [PDF]

open access: yes, 2001
The author recommends that a stronger emphasis be placed on creating and implementing short-term tests that use iterative, conservative-based, tiered procedures in conjunction with a precautionary attitude during the interim phase of toxicological risk ...
Riley, Timothy
core   +1 more source

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