Results 81 to 90 of about 354,109 (308)

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

open access: yesAdvanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang   +8 more
wiley   +1 more source

Contribution of thirdhand smoke to overall tobacco smoke exposure in pediatric patients: study protocol. [PDF]

open access: yes, 2019
BackgroundThirdhand smoke (THS) is the persistent residue resulting from secondhand smoke (SHS) that accumulates in dust, objects, and on surfaces in homes where tobacco has been used, and is reemitted into air.
Geraci, Maegan A   +12 more
core   +1 more source

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

open access: yesAdvanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao   +12 more
wiley   +1 more source

Heavy metals health risk assessment through consumption of some foodstuffs marketed in city of Hamedan, Iran [PDF]

open access: yesCaspian Journal of Environmental Sciences, 2019
Since global studies on the health risk assessment of heavy metals in foodstuffs, including biscuits, potato chips, chocolates, and traditional pastries are limited, hence, this study was conducted to determine the contents and the human health risk ...
S Sobhanardakani
doaj   +1 more source

Health Hazard Manual For Cutting Oils, Coolants, and Metalworking Fluids [PDF]

open access: yes, 1991
[Excerpt] The metalworker can be exposed to cutting oils during application by two basic routes of entry: skin contact and inhalation. The higher risk jobs tend to be those with high cutting speeds, heavy oil flow, and continuous contact, which may ...
Brown, Nellie J
core   +1 more source

The two-stage clonal expansion model in occupational cancer epidemiology: Results from three cohort studies [PDF]

open access: yes, 2010
Copyright © 2010 by the BMJ Publishing Group Ltd. All rights reserved.Objectives: The objective of this work was to apply the two-stage clonal expansion model, with the intention to expand the literature on epidemiological applications of the model and ...
Gore, R, Kriebel, D, Zeka, A
core   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu   +13 more
wiley   +1 more source

Risks of Carcinogenic Pollution in Wood Industry within European Regulations

open access: yesDrvna Industrija
Many materials used in wood industry are considered to have carcinogenic or mutagenic effects, which is a health risk for workers in production. Carcinogenic chemical compounds, apart from causing cancer, also pose a great risk for human health in other ...
Antonio Kruljac, Anka Ozana Čavlović
doaj   +1 more source

Redressing the Silent Interim: Precautionary Action & Short Term Tests in Toxicological Risk Assessment [PDF]

open access: yes, 2001
The author recommends that a stronger emphasis be placed on creating and implementing short-term tests that use iterative, conservative-based, tiered procedures in conjunction with a precautionary attitude during the interim phase of toxicological risk ...
Riley, Timothy
core   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

open access: yesAdvanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu   +16 more
wiley   +1 more source

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