Results 61 to 70 of about 282,417 (263)

Single‐molecule methods, activation‐induced cytidine deaminase, and quantum mechanical approach to explore and prevent carcinogenesis

View
Recent advancements in single‐molecule methods have not only made it possible to obtain precise measurements for complex biological processes but also to produce simple mathematical models for intricate biochemical mechanisms, which would otherwise be ...
Asad Ullah, Neelam Mabood, Mujib Ullah, Mohsin Shafi, Muhammad Maqbool   +4 more
doaj   +1 more source

Machine Learning for Green Solvents: Assessment, Selection and Substitution

Advanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta, Janhavi Nistane, Abhishek Sose, Harikrishna Sahu, Rampi Ramprasad   +4 more
wiley   +1 more source

Health effects of exposure to static magnetic field − a review of literature

Medycyna Pracy, 2019
The authors discuss the effects of static magnetic field (SMF) exposure based on reviewed literature reports. The systematic review covered both research carried out directly with people as well as studies with animals.
Marek Zmyślony, Piotr Politański
doaj   +1 more source

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source

Heavy metals health risk assessment through consumption of some foodstuffs marketed in city of Hamedan, Iran [PDF]

Caspian Journal of Environmental Sciences, 2019
Since global studies on the health risk assessment of heavy metals in foodstuffs, including biscuits, potato chips, chocolates, and traditional pastries are limited, hence, this study was conducted to determine the contents and the human health risk ...
S Sobhanardakani
doaj   +1 more source

RBM10 Deficiency Promotes Anti‐PD‐1 Resistance in LUAD via STING Alternative Splicing‐Driven CCL7 Signaling and Macrophage Polarization

Advanced Science, EarlyView.
RBM10 deficiency promotes anti‐PD‐1 resistance in lung adenocarcinoma by altering STING alternative splicing, which enhances CCL7 secretion and CCR2‐dependent M2 macrophage polarization. A positive feedback loop via mitochondrial transfer sustains this immunosuppression.
Weitong Gao, Ruqiong Wang, Bo An, Lishuang Qi, Zihan Jing, Xingmei Ren, Yang Zhou, Mingjun Xu, Jiaojiao Li, Jie Liu, Liying Wang, Gang Xu, Rou Li, Dexin Jia, Yan Yu   +14 more
wiley   +1 more source

Risks of Carcinogenic Pollution in Wood Industry within European Regulations

Drvna Industrija
Many materials used in wood industry are considered to have carcinogenic or mutagenic effects, which is a health risk for workers in production. Carcinogenic chemical compounds, apart from causing cancer, also pose a great risk for human health in other ...
Antonio Kruljac, Anka Ozana Čavlović
doaj   +1 more source

Gut Microbiota, Immunity, and Metabolism in the Progression From Chronic Liver Disease to Hepatocellular Carcinoma

Advanced Science, EarlyView.
This review explains how chronic liver injury progresses toward hepatocellular carcinoma through interconnected changes in gut microbes, metabolism, immunity, fibrosis, and diet. It highlights microbial metabolites, bile‐acid signaling, immune dysfunction, and nutritional or microbiome‐based interventions as opportunities to identify risk earlier ...
Yi Hu, Caiyan Lin, Lijie Zhang, Xue Jiang, Huawen Li, Yangzhe Wu   +5 more
wiley   +1 more source

The impact of vaping and smoking on nicotine intake and toxicant exposure among youth in England compared with youth in North America

Public Health Research
Background Youth vaping prevalence varies across countries and may be related to differing regulations/products. The emergence of cheap disposable vapes and high-concentration nicotine salts heightened concerns related to youth’s ease of access ...
Ann McNeill, Deborah Robson, David Hammond, Jessica L Reid, Maciej L Goniewicz, Ashleigh C Block, Richard J O’Connor, Maria Nikolaidou, Eve Taylor, Katherine East, Eileen Brobbin, Sarah Aleyan, Marzena Orzol, Kirstie Soar, John Robins, Leonie S Brose   +15 more
doaj   +1 more source

ML Workflows for Screening Degradation‐Relevant Properties of Forever Chemicals

Advanced Science, EarlyView.
The environmental persistence of per‐ and polyfluoroalkyl substances (PFAS) necessitates efficient remediation strategies. This study presents physics‐informed machine learning workflows that accurately predict critical degradation properties, including bond dissociation energies and polarizability.
Pranoy Ray, Andrew R. Castillo, Manoj Kolel‐Veetil, Surya R. Kalidindi   +3 more
wiley   +1 more source