Results 121 to 130 of about 372,123 (339)

Detection of genotoxic and non-genotoxic renal carcinogens in vitro in NRK-52E cells using a transcriptomics approach. (2012). [PDF]

There is a need to develop quick, cheap, sensitive and specific methods to detect the carcinogenic potential of chemicals. Currently there is no in vitro model system for reliable detection of non-genotoxic carcinogens (NGTX) and current tests for ...
Bloch, KM, Boei, JWA, Evans, AR, Gmuender, H, Jennings, P, Lock, EA, McMorrow, T, Radford, R, Ryan, MP, Slattery, C, van Delft, JHM, Yaqoob, N   +11 more
core  

Polystyrene Microplastics Exposure Aggravates Clear Cell Renal Cell Carcinoma Progression via the NF‐κB and TGF‐β Signaling Pathways

Advanced Science, EarlyView.
This research provides the first comprehensive evidence that PS‐MPs exacerbate ccRCC progression by activating the NF‐κB and TGF‐β pathways. These findings establish PS‐MPs as an environmental risk factor for ccRCC progression and identify the NF‐κB and TGF‐β signaling as potential therapeutic targets to mitigate the adverse effects of ‐PS‐MPs exposure.
Shiqi Ye, Jianfeng Xiang, Siqi Zhou, Qintao Ge, Aihetaimujiang Anwaier, Kun Chang, Gang Wei, Jiahe Lu, Xi Tian, Shuxuan Zhu, Yuchen Jiang, Wei Zhang, Tingting Cai, Moran Xu, Dingwei Ye, Danfeng Xu, Tao Wang, Hailiang Zhang, Wenhao Xu   +18 more
wiley   +1 more source

Enhanced‐Type Quantitative Luminescence Recognition for Per‐ and Polyfluoroalkyl Substances (PFAS) by a Metal–Organic Framework Single Crystal

Angewandte Chemie, EarlyView.
A millimeter‐sized luminescent metal–organic framework (MOF) single crystal is developed as a robust, reusable sensor for per‐ and polyfluoroalkyl substances (PFAS). Unlike conventional sensing conducted by MOF powders, the single crystal enables easy usage, improved stability, and enhanced luminescence response, facilitating practical PFAS detection ...
Zongsu Han, Yifan Guo, Kun‐Yu Wang, Wenxuan Li, Jiatong Huo, Qingya Huang, Vladimir I. Bakhmutov, Yihao Yang, Rong‐Ran Liang, Peter R. Taylor, Wei Shi, Hong‐Cai Zhou   +11 more
wiley   +2 more sources

Carcinogenic Chemicals in Occupational Settings: A Tool for Comparison and Translation between Different Classification Systems

Hygiene
In the European Union, Occupational Safety and Health legislation generally refers to European Regulation (CE) n. 1272/2008 to define and classify carcinogens of concern for occupational risk assessment and exposure assessment.
Carolina Zellino, Andrea Spinazzè, Francesca Borghi, Davide Campagnolo, Giacomo Fanti, Marta Keller, Alessio Carminati, Sabrina Rovelli, Andrea Cattaneo, Domenico Maria Cavallo   +9 more
doaj   +1 more source

Hierarchically Porous Nitrogen‐Doped Carbon with High Conductivity for Rapid and Efficient Cr(VI) Reduction

Advanced Science, EarlyView.
The d‐PNC(1100, 10%) catalyst, synthesized via a zinc‐based ionic liquid self‐sacrificing pore‐forming strategy to create a defect‐rich, hierarchical, nitrogen‐doped porous structure, enhances conductivity, promotes rapid mass transfer and synergistic catalytic activity, driving efficient Cr(VI) reduction in OA solution to generate Cr(III)‐OA complexes.
Danyan Lin, Jie Yang, Fengfeng Chen, Xishi Tai, Zhongshan Chen, Xinrong Guo, Xiangke Wang, Wen Yao   +7 more
wiley   +1 more source

A theory for the tissue specificity of BRCA1/2 related and other hereditary cancers [PDF]

, 2010
Women who inherit a defective BRCA1 or BRCA2 gene have risks for breast and ovarian cancer that are so high and seem so selective that many mutation carriers choose to have prophylactic surgery. There has been much conjecture to explain such apparently
Bernard Friedenson
core   +1 more source

Nanozymes Integrated Biochips Toward Smart Detection System

Advanced Science, EarlyView.
This review systematically outlines the integration of nanozymes, biochips, and artificial intelligence (AI) for intelligent biosensing. It details how their convergence enhances signal amplification, enables portable detection, and improves data interpretation.
Dongyu Chen, Wang Zheng, Zhihui Zhang, Shenping Yu, Xinxin Hang, Han Wu, Xiao‐Wei Xiang, Wei Mu, Yanli Jiao, Zaizai Dong, Lingqian Chang   +10 more
wiley   +1 more source

Spatial heterogeneity of KRAS mutations in colorectal cancers in northern France

Cancer Management and Research, 2019
Anthony Turpin,1–3 Michael Genin,4 Mohamed Hebbar,1,2 Florent Occelli,5 Caroline Lanier,5 Francis Vasseur,4 Clotilde Descarpentries,6 Diane Pannier,7 Anne Ploquin1 1Medical oncology unit, Hôpital Claude Huriez, F-59000 Lille, France; 2Lille ...
Turpin A, Genin M, Hebbar M, Occelli F, Lanier C, Vasseur F, Descarpentries C, Pannier D, Ploquin A   +8 more
doaj  

Synergetic Relay Between Atomic Hydrogen and Chlorine Radicals Enables Efficient Nitrate‐to‐Nitrogen Gas Conversion

Advanced Science, EarlyView.
Using photoelectrochemical (PEC) deep denitrification technology, a novel synergistic reduction‐oxidation process enables efficient conversion of nitrate (NO3−) to nitrogen (N2), while suppressing key intermediate ammonium (NH4+) and toxic nitrite (NO2−) accumulation.
Yongjie Wang, Ying Tao, Chi Zhang, Shan Hu, Yuxin Shi, Jixing Wang, Jiacheng Zhang, Chen Cheng, Ying Wang, Guisheng Li, Zichao Lian, Dieqing Zhang   +11 more
wiley   +1 more source

Serum Bile Acids Are Useful Indicators of Intrahepatic Recurrence After Initial Curative Hepatectomy for Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim Bile acids accumulation in hepatocytes causes liver damage and contributes to the development of hepatocellular carcinoma. However, the association between serum bile acid levels and postoperative intrahepatic recurrence in hepatocellular carcinoma remains unclear.
Tomoaki Bekki, Masahiro Ohira, Yuki Imaoka, Seiichi Simizu, Tomoyuki Abe, Shintaro Kuroda, Hiroyuki Tahara, Kentaro Ide, Tsuyoshi Kobayashi, Hideki Ohdan   +9 more
wiley   +1 more source