An integrated in vitro carcinogenicity test that distinguishes between genotoxic carcinogens, non-genotoxic carcinogens, and non-carcinogens [PDF]
MutagenesisAbstract Chemical safety testing plays a crucial role in product and pharmacological development, as well as chemoprevention; however, in vitro genotoxicity safety tests do not always accurately predict the chemicals that will be in vivo carcinogens.
Katherine E Chapman +5 more
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Cadmium, carcinogen, co-carcinogen and anti carcinogen [PDF]
Indian Journal of Clinical Biochemistry, 2001 As a stress agent, inducing apoptosis and blocking it, Cd can have both helpful and harmful effects. The atmosphere is a thin envelope which makes the worid a global village. Cd is the most toxic metal in air. As both the first and second messenger of the stress response, it is synergistically toxic with all other stressors, including many other ...
Priyanka Tomar +3 more
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Global and regional burden of cancer in 2016 arising from occupational exposure to selected carcinogens: a systematic analysis for the Global Burden of Disease Study 2016. [PDF]
, 2020 OBJECTIVES: This study provides a detailed analysis of the global and regional burden of cancer due to occupational carcinogens from the Global Burden of Disease 2016 study.
GBD 2016 Occupational Carcinogens Collaborators
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Oxidative Stress in the Carcinogenicity of Chemical Carcinogens [PDF]
Cancers, 2013 This review highlights several in vivo studies utilizing non-genotoxic and genotoxic chemical carcinogens, and the mechanisms of their high and low dose carcinogenicities with respect to formation of oxidative stress. Here, we survey the examples and discuss possible mechanisms of hormetic effects with cytochrome P450 inducers, such as phenobarbital, a-
Anna Kakehashi +3 more
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Nonmutagenic carcinogens induce intrachromosomal recombination in dividing yeast cells. [PDF]
, 1993 A large number of animal and human carcinogens without apparent genotoxic activity exist (nonmutagenic carcinogens) that are difficult or impossible to detect with the currently used short-term tests.
Schiestl, RH
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Threshold in Carcinogenicity of Genotoxic Carcinogens [PDF]
Journal of Carcinogenesis & Mutagenesis, 2014 Nowadays the idea of threshold in the carcinogenicity of chemical carcinogens has attracted interest in the field of carcinogenesis. With genotoxic agents there is considerable experimental evidence in support of the idea. Here, we report on the low dose carcinogenicity in rats observed with heterocyclic amines contained in cooked food, 2-amino-3,8 ...
Hideki Wanibuchi +3 more
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Preventing hereditary cancers caused by opportunistic carcinogens [PDF]
, 2011 Objectives Previous studies reported inherited BRCA1/2 deficits appear to cause cancer by impairing normal protective responses to some carcinogens.
Bernard Friedenson
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Cell transformation assays for prediction of carcinogenic potential: State of the science and future research needs [PDF]
, 2011 Copyright @ 2011 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use ...
A. D. Scott +65 more
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The Carcinogenicity of Chromium [PDF]
Environmental Health Perspectives, 1981 The carcinogenicity of chromium compounds is reviewed with specific attention to the gaps in knowledge for risk estimation and research needs. The most important problems at present are whether trivalent chromium compounds cause cancer, and whether there is a difference in cancer causing effects between the soluble and the slightly soluble hexavalent ...
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Carcinogenicity of chloroform. [PDF]
Environmental Health Perspectives, 1979 Chloroform is carcinogenic in rats, mice, and probably in dogs. Chloroform induced carcinomas of the liver and kidney and malignant tumors in other organs in rats and mice. Liver neoplasms have been described in three strains of mice. Carcinomas of the kidney were found in a first study in mice and in the repeat of that study.
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