A Tukey type trend test for repeated carcinogenicity bioassays, motivated by multiple glyphosate studies [PDF]
arXiv, 2020 In the last two decades, significant methodological progress to the simultaneous inference of simple and complex randomized designs, particularly proportions as endpoints, occurred. This includes: i) the new Tukey trend test approach, ii) multiple contrast tests for binomial proportions, iii) multiple contrast tests for poly-k estimates, and Add-1 ...
arxiv
A versatile trend test for the evaluation of tumor incidences in long-term carcinogenicity bioassays [PDF]
arXiv, 2020 For the evaluation of carcinogenicity bioassays a new trend test is proposed which is based on a maximum of arithmetic, ordinal, and logarithmic regression scores as well as the Williams-type contrasts for either crude proportions or more appropriate poly3-estimates for the tumor-by-time relationships. This test provides an almost appropriate power for
arxiv
A Comparative Study of Disordered and Ordered Protein Folding Dynamics Using Computational Simulation [PDF]
arXiv, 2022 Folding protein dynamics has been an area of high interest for quite some time, especially given the increased focus on the field of Biophysics. Because folding dynamics occur on such short time scales, empirical techniques developed for more "static" protein events, such as X-ray crystallography, nuclear magnetic resonance, and green fluorescent ...
arxiv
, 2010 Mycotoxins are metabolites of molds considered to be a major risk factor affecting human and animal health. It is estimated that 25% of the world’s crop production is contaminated with mycotoxins. Mold contamination occurs extensively in fields and it is particularly severe in tropical countries.
M. Peraica, A.-M. Domijan
openaire +3 more sources
From GWAS to transcriptomics in prospective cancer design - new statistical challenges [PDF]
arXiv, 2013 Background. With the increasing interest in post-GWAS research which represents a transition from genome-wide association discovery to analysis of functional mechanisms, attention has been lately focused on the potential of including various biological material in epidemiological studies.
arxiv
Nanoscale intracellular mass-density alteration as a signature of the effect of alcohol on early carcinogenesis: A transmission electron microscopy (TEM) study [PDF]
arXiv, 2015 Alcohol consumption interferes with the functioning of multiple organ systems, causing changes in the chemistry, physiology and pathology of tissues and cellular organelles. Although epigenetic modifications underlie the development of cancer, exposure to carcinogenic chemicals, such as alcohol, can also contribute to disease development.
arxiv
Modeling and simulation of a low grade urinary bladder carcinoma [PDF]
arXiv, 2013 In this work, we present a mathematical model of the initiation and progression of a low-grade urinary bladder carcinoma. We simulate the crucial processes involved in tumor growth, such as oxygen diffusion, carcinogen penetration, and angiogenesis, within the framework of the urothelial cell dynamics.
arxiv
Superior-catalytic performance of Ni-Co Layered double hydroxide nanosheets for the reduction of p-nitrophenol [PDF]
arXiv, 2022 Layered double-hydroxides (LDHs) are superior to the conventional (Transition Metal Oxides) TMOs as their lamellar morphology accommodates higher active sites contributing to the facile electron transfer towards the material degradation relations, thus attracts an immense attention for catalysis application.
arxiv
An integrated in vitro carcinogenicity test that distinguishes between genotoxic carcinogens, non-genotoxic carcinogens, and non-carcinogens [PDF]
MutagenesisAbstract Chemical safety testing plays a crucial role in product and pharmacological development, as well as chemoprevention; however, in vitro genotoxicity safety tests do not always accurately predict the chemicals that will be in vivo carcinogens.
Katherine E Chapman +5 more
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Risk Agoras: Dialectical Argumentation for Scientific Reasoning [PDF]
arXiv, 2013 We propose a formal framework for intelligent systems which can reason about scientific domains, in particular about the carcinogenicity of chemicals, and we study its properties. Our framework is grounded in a philosophy of scientific enquiry and discourse, and uses a model of dialectical argumentation.
arxiv