Results 121 to 130 of about 454,519 (294)

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta   +2 more
wiley   +1 more source

Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response. [PDF]

, 2019
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and confers a poor prognosis. Beyond standard systemic therapy with multikinase inhibitors, recent studies demonstrate the potential for robust and durable responses ...
Fong, Lawrence, Keenan, Bridget P, Kelley, Robin K   +2 more
core   +1 more source

Multimodality Treatment with Conventional Transcatheter Arterial Chemoembolization and Radiofrequency Ablation for Unresectable Hepatocellular Carcinoma [PDF]

, 2012
Background/Aims: To evaluate the efficacy of multimodality treatment consisting of conventional transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA) in patients with non-resectable and non-ablatable hepatocellular carcinoma ...
Albrecht T, Bloomston M, Bosch FX, Bruix J, Bruix J, Buscarini E, Buscarini L, Buscarini L, C. Trumm, Camma C, Clasen S, Dupuy DE, El-Serag HB, F. Bamberg, F.T. Kolligs, Geschwind JF, Jemal A, Kagawa T, Kettenbach J, Kim JH, Kirikoshi H, Lencioni R, Lencioni R, Lencioni R, Lencioni RA, Lin SM, Lin SM, Livraghi T, Livraghi T, Llovet JM, Llovet JM, Lo CM, M. Rentsch, M.F. Reiser, Marelli L, Marrero JA, N. Ashoori, Oken MM, P. Paprottka, Parkin DM, Poon RT, Rossi S, Sherman M, Shiina S, T.F. Jakobs, Veltri A, Vetter D, Yamakado K, Zhang L   +48 more
core   +1 more source

Discovery of new drug therapeutic indications from gene mutation information for hepatocellular carcinoma [PDF]

arXiv, 2017
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is a leading cause of cancer-related death worldwide. However, cure is not possible with currently used therapies, and there is not so much approved targeted therapy for HCC despite numerous attempts and clinical trials. So, it is essential to identify additional therapeutic
arxiv  

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

Modularity of the metabolic gene network as a prognostic biomarker for hepatocellular carcinoma [PDF]

arXiv, 2017
Abnormal metabolism is an emerging hallmark of cancer. Cancer cells utilize both aerobic glycolysis and oxidative phosphorylation (OXPHOS) for energy production and biomass synthesis. Understanding the metabolic reprogramming in cancer can help design therapies to target metabolism and thereby to improve prognosis.
arxiv  

Tissue Like Density Sheets of Hepatoblastoma Cultures Obtained with Thin Suspended Hydrogels Mimicking In Vivo Inter‐Capillary Distances

Advanced Materials Technologies, EarlyView.
Inserts for standard well plates are produced using vacuum forming, resulting in well‐defined bottom thicknesses down to 50 µm. After opening apertures through the bottom, hydrogels can be cast to similar thicknesses. Introducing HepG2 cells into this very thin hydrogel allows for 3D cell cultures with densities close to in vivo conditions.
Alexander Jönsson, Hakan Gürbüz, Louise Wildfang, Pernille Rose Jensen, Martin Dufva   +4 more
wiley   +1 more source

Achieving Optimal Health With Host‐Directed Therapies (HDTs) in Infectious Diseases—A New Horizon

Advanced Therapeutics, EarlyView.
Host‐directed therapies (HDTs) represent a transformative approach in infectious disease management by targeting host factors to enhance immune responses and inhibit viral replication. This innovative strategy leverages advanced genomics and gene editing technologies, offering promising avenues for improved patient outcomes and a new horizon in ...
Amol D. Gholap, Pankaj R. Khuspe, Sagar R. Pardeshi, Md Jasim Uddin, Ushasi Das, Navnath T. Hatvate, Satish Rojekar, Prabhanjan Giram, Mohammad Khalid, Yahya E. Choonara, Md. Faiyazuddin   +10 more
wiley   +1 more source

ONC206 targeting ClpP induces mitochondrial dysfunction and protective autophagy in hepatocellular carcinoma cells

Neoplasia: An International Journal for Oncology Research
Hepatocellular carcinoma (HCC) is the most common form of liver cancer, accounting for approximately 90 % of all cases. ONC201, a member of the imipridone drug family, has shown promising therapeutic potential and a good safety profile in both malignant ...
Jiahao Cao, Fei Cao, Chuanzheng Wang, Zhen Jiao, Yuting You, Xiaomin Wang, Wenxiu Zhao   +6 more
doaj  

Diagnostic performance of tumor markers AFP and PIVKA-II in Chinese hepatocellular carcinoma patients

Tumor Biology, 2017
Alpha-fetoprotein is an effective biomarker as an aid in hepatocellular carcinoma detection in many countries. However, alpha-fetoprotein has its limitations, especially in early hepatocellular carcinoma diagnosis. Protein induced by vitamin K absence or
Shujing Huang, Feifei Jiang, Ying Wang, Yanhua Yu, Siqian Ren, Xiaowei Wang, Peng Yin, Jinli Lou   +7 more
doaj   +1 more source