Results 131 to 140 of about 454,519 (294)

Interplay of miRNAs and Canonical Wnt Signaling Pathway in Hepatocellular Carcinoma

Frontiers in Pharmacology, 2018
Hepatocellular carcinoma is one of the leading causes of cancer death worldwide and the activation of canonical Wnt signaling pathway is universal in hepatocellular carcinoma patients.
Xiaobo Nie, Yiran Liu, Yiran Liu, Wei-Dong Chen, Wei-Dong Chen, Yan-Dong Wang   +5 more
doaj   +1 more source

Clinical applications of squamous cell carcinoma antigen-immunoglobulins M to monitor chronic hepatitis C [PDF]

, 2015
Hepatitis C virus (HCV) is the main cause of chronic liver disease and cirrhosis in Western countries. Over time, the majority of cirrhotic patients develop hepatocellular carcinoma (HCC), one of the most common fatal cancers worldwide - fourth for ...
Fassina, Giorgio, Gallotta, Andrea, MARTINI, ANDREA, PONTISSO, PATRIZIA   +3 more
core   +1 more source

Accelerated Bone Healing via Electrical Stimulation

Advanced Science, EarlyView.
Electrical stimulation significantly impacts bone healing by enhancing osteoblast proliferation, differentiation, and vascularization through calmodulin/calcineurin/NFAT signaling. It also boosts macrophage function and cell migration, presenting a comprehensive approach to accelerating bone repair.
Jianfeng Sun, Wenqing Xie, Yuxiang Wu, Zhou Li, Yusheng Li   +4 more
wiley   +1 more source

HCC-Check: A Novel Diagnostic Tool for Early Detection of Hepatocellular Carcinoma Based on Cytokeratin-1 and Epithelial Membrane Antigen: A Cross-Sectional Study

Technology in Cancer Research & Treatment
Background: Hepatocellular carcinoma is frequently diagnosed in advanced stages, leading to a poorer prognosis. Therefore, early diagnosis and identification of biomarkers may significantly improve outcomes.
Kareem A. Attallah MSc, Mohamed S. Albannan PhD, Khaled Farid MD, PhD, Sherine M. Rizk PhD, Nevine Fathy PhD   +4 more
doaj   +1 more source

Protein induced by vitamin K absence or antagonist-II (PIVKA-II) specifically increased in Italian hepatocellular carcinoma patients [PDF]

, 2016
OBJECTIVE: As a marker for Hepatocellular Carcinoma (HCC), Protein Induced by Vitamin K Absence II (PIVKA-II) seems to be superior to alpha fetoprotein (AFP).
Anastasi, Emanuela, Angeloni, Antonio, D'Ettorre, Gabriella, DE VITO, Corrado, Frati, Luigi, Gennarini, Giuseppina, Palombi, S, Viggiani, Valentina   +7 more
core   +1 more source

The FBXW7‐RPAP2 Axis Controls the Growth of Hepatocellular Carcinoma Cells and Determines the Fate of Liver Cell Differentiation

Advanced Science, EarlyView.
The study shows that RPAP2, acting as an oncoprotein, promotes hepatocellular carcinoma (HCC) progression, with its stability being negatively regulated by FBXW7, yet positively by HSP90 and USP7. The FBXW7‐RPAP2 axis plays a crucial role in controlling HCC cell growth and influencing liver cell differentiation.
Danrui Cui, Shengpeng Shao, Ruirui Qu, Xiaoyu Chen, Shanghong Jiang, Linchen Wang, Longyuan Gong, Tianqi Li, Danyi Zhai, Wenfeng Song, Penghong Song, Yi Sun, Tingbo Liang, Xiufang Xiong, Yongchao Zhao   +14 more
wiley   +1 more source

Ribonuclease 1 Induces T‐Cell Dysfunction and Impairs CD8+ T‐Cell Cytotoxicity to Benefit Tumor Growth through Hijacking STAT1

Advanced Science, EarlyView.
T‐cell immunotherapy eliminates cancer growth by activating T cells, but immunosuppressive factors hinders their effectiveness, resulting in treatment failure. Here, ribonuclease 1 (RNase1) causes T‐cell dysfunction and promotes exhausted T‐cell signatures in cancers.
Wen‐Hao Yang, Bao‐Yue Huang, Hsing‐Yu Rao, Peng Ye, Bi Chen, Hao‐Ching Wang, Chih‐Hung Chung, Heng‐Hsiung Wu, Hung‐Rong Yen, Shao‐Chun Wang, Jong‐Ho Cha, Xiuwen Yan, Muh‐Hwa Yang, Mien‐Chie Hung   +13 more
wiley   +1 more source

Abnormal prothrombin (DES-y-Carboxy Prothrombin) in hepatocellular carcinoma [PDF]

, 1991
Des-γ-carboxy prothrombin (DCP), a protein induced by vitamin K absence or antagonist-II (PIVKA-II) was measured by an enzyme immunoassay (E-1023) using anti-DCP monoclonal antibody in 92 patients with various hepatobiliary diseases. Thirty-six of the 38
Carr, B, Iwaki, Y, Iwatsuki, S, Nakao, A, Starzl, E, Virji, A   +5 more
core  

CCL20/CXCL5 Drives Crosstalk Between Anaplastic Thyroid Cancer Stem Cells and Tumor‐Associated Macrophages to Promote Tumor Progression

Advanced Science, EarlyView.
This study elucidates the crosstalk between tumor‐associated macrophages (TAMs) and anaplastic thyroid cancer stem cells (ATCSCs). The findings reveal that CCL20 from THP‐1‐M2 activates the IRAK‐1/NF‐κB1/2 pathway in ATCSCs, thereby enhancing CXCL5 secretion.
Qi Liu, Yan Wang, Mingyuan Song, Jiapeng Huang, Jinyuan Shi, Wei Sun, Xiaoyu Ji, Yuang Chang, Bing Ma, Ping Zhang, Yuanyuan Yan, Hao Zhang   +11 more
wiley   +1 more source

Tracing the Evolution of Sex Hormones and Receptor‐Mediated Immune Microenvironmental Differences in Prostate and Bladder Cancers: From Embryonic Development to Disease

Advanced Science, EarlyView.
Prostate and bladder cancers activate genes and pathways similar to those in the developmental stage by aggregating and analyzing current data. In this process, sex hormones and their receptors maybe a key role in causing and reversing the “cold” and “hot” immune tumor phenotypes, potentially enhancing the immune response.
Dengxiong Li, Zhipeng Wang, Qingxin Yu, Jie Wang, Ruicheng Wu, Zhouting Tuo, Koo Han Yoo, Dilinaer Wusiman, Luxia Ye, Yiqing Guo, Yubo Yang, Fanglin Shao, Ziyu Shu, Uzoamaka Okoli, William C. Cho, Wuran Wei, Dechao Feng   +16 more
wiley   +1 more source