Results 161 to 170 of about 454,519 (294)

Hepatocellular Carcinoma (HCC) Surveillance – Comprehensive Management in Liver Cirrhosis Patients [PDF]

, 2017
Gani, R. A. (Rino)
core   +1 more source

Paediatric hepatoblastoma and hepatocellular carcinoma: retrospective study. [PDF]

, 2002
OBJECTIVES: To compare and contrast clinical characteristics and outcomes of hepatoblastoma or hepatocellular carcinoma in paediatric patients. DESIGN: Retrospective study. SETTING: University teaching hospital, Hong Kong.
Chan, GC, Chan, KL, Chiang, AK, Fan, ST, Ha, SY, Tam, PK   +5 more
core  

Chemotherapy‐Mediated Induction of PD‐L1 via SEI1 Facilitates Myeloma Immune Evasion

Advanced Science, EarlyView.
Chemotherapy induces DNA damage, activating cyclic guanosine monophosphate (GMP)‐adenosine monophosphate (AMP) synthase (cGAS)/stimulator of interferon genes (STING), which phosphorylates interferon regulatory factor 7 (IRF7) to drive SERTA‐containing domain 1 (SEI1) transcription.
Rui Chen, Zongwei Li, Zhihong Fang, Zou Li, Daoyan Yang, Yuan Li, Shurong Liu, Zhiqiang Liu, Rui Liu, Huan Liu   +9 more
wiley   +1 more source

EIF4A3‐Mediated Biogenesis of CircFADS1 Promotes the Progression of Hepatocellular Carcinoma via Wnt/β‐Catenin Pathway

Advanced Science, EarlyView.
In this study, a novel circRNA, circFADS1 is identified, which is expressed at higher levels in HCC. circFADS1 is associated with poor prognosis in HCC patients and promotes HCC cell proliferation while inhibiting apoptosis. Mechanistically, circFADS1 exerts its biological function through the EIF4A3/GSK3β/β‐catenin axis and is closely associated with ...
Lei Tang, Yang Ji, Chuangye Ni, Zhenggang Xu, Yanjun Shen, Hao Lu, Chuanyong Zhang, Shikun Yang   +7 more
wiley   +1 more source

Cost‐Effective Identification of Hepatocellular Carcinoma from Cirrhosis or Chronic Hepatitis Virus Infection Using Eight Methylated Plasma DNA Markers

Advanced Science, EarlyView.
Early detection of hepatocellular carcinoma in patients with liver cirrhosis and/or hepatitis virus B/C infection improves survival. Through marker discovery, 8 methylated DNA markers are identified and a logistic regression model (COMET‐LR) is built in the training set, which achieved 90.0% sensitivity at 97.4% specificity in the validation set.
Tian Yang, Mingda Wang, Nanya Wang, Mingxin Pan, Yu Xu, Qiancheng You, Lanqing Yao, Jiahao Xu, Lihui Gu, Xiaodong Sun, Lei Zhang, Jiayue Xu, Bingsi Li, Guoqiang Wang, Shangli Cai, Guoyue Lv, Feng Shen   +16 more
wiley   +1 more source

Lactylation‐Driven HECTD2 Limits the Response of Hepatocellular Carcinoma to Lenvatinib

Advanced Science, EarlyView.
HECTD2 serves as an E3 ubiquitin ligase of KEAP1 to facilitate the antioxidative response and contributes to lenvatinib resistance in hepatocellular carcinoma. Lactylation of histone 3 on lysine residue 18 drives HECTD2 transcription. Targeting HECTD2 using PLGA‐PEG‐based nanoparticles offers novel strategies to overcome lenvatinib resistance in ...
Runyu Dong, Yao Fei, Yiren He, Peng Gao, Bo Zhang, Menglin Zhu, Zhixiong Wang, Longfei Wu, Shuai Wu, Xiaoming Wang, Juan Cai, Zhiqiang Chen, Xueliang Zuo   +12 more
wiley   +1 more source

Integrative Multi‐Omics Approaches Reveal Selectivity Profiles and Molecular Mechanisms of FIIN‐2, a Covalent FGFR Inhibitor

Advanced Science, EarlyView.
Using integrative multi‐omics analyses, this study maps FIIN‐2's targets and signaling networks in liver cancer cells, and identifies covalent AMPKα1 binding as a novel autophagy‐activating mechanism. The findings resolve both on‐target FGFR inhibition and off‐target protein engagement, providing a molecular roadmap to refine covalent kinase inhibitors
Ying Fu, Dandan Zhu, Xiaojuan Chen, Lingzhi Qu, Ming Guo, Shuhong Zhang, Guangyu Xu, Zhuchu Chen, Maoyu Li, Yongheng Chen   +9 more
wiley   +1 more source

CMTM6 promotes hepatocellular carcinoma invasion and metastasis and tumor-associated neutrophil immunoinfiltration through the Wnt/β-catenin pathway

European Journal of Medical Research
Background CMTM6 has been closely associated with the onset and progression of various tumor types. However, the precise mechanism by which CMTM6 operates in hepatocellular carcinoma remains elusive, necessitating further investigation.
Panpan Kong, Huan Yang, Huifang Liu, Qing Tong, Mamumaimaitijiang-Abula Yi, Yong Zhao, Dong Yan   +6 more
doaj   +1 more source

Targeting Histone Deacetylase 11 with a Highly Selective Inhibitor for the Treatment of MASLD

Advanced Science, EarlyView.
A potent HDAC11‐specific inhibitor, B6, is identified using substrate‐mimic and bioisosteric replacement strategies. B6 demonstrates high oral bioavailability, extensive liver distribution, and a favorable safety profile. B6 effectively alleviates metabolic dysfunction‐associated steatotic liver disease by increasing the expression of LKB1 and ...
Feng Zhang, Kairui Yue, Simin Sun, Shengyuan Lu, Geng Jia, Yang Zha, Shuang Zhang, C. James Chou, Chenzhong Liao, Xiaoyang Li, Yajun Duan   +10 more
wiley   +1 more source

Deciphering the Oncogenic Landscape of Hepatocytes Through Integrated Single‐Nucleus and Bulk RNA‐Seq of Hepatocellular Carcinoma

Advanced Science, EarlyView.
By combining snRNA‐seq and bulk RNA‐seq, this study identified key hepatocyte subtypes, genes, and pathways in HCC. It established a Quantile Distribution Model, providing potential targets for HCC diagnosis and treatment. It categorized HCC into metabolic, inflammatory, and matrix classes, each with sensitive drugs identified.
Huanhou Su, Xuewen Zhou, Guanchuan Lin, Chaochao Luo, Wei Meng, Cui Lv, Yuting Chen, Zebin Wen, Xu Li, Yongzhang Wu, Changtai Xiao, Jian Yang, Jiameng Lu, Xingguang Luo, Yan Chen, Paul KH Tam, Chuanjiang Li, Haitao Sun, Xinghua Pan   +18 more
wiley   +1 more source