Results 161 to 170 of about 1,627,756 (267)

Lenvatinib Plus Paclitaxel as Second‐Line Therapy for Advanced Gastric Cancer Patients: A Dose Escalation Exploratory Study

open access: yesAdvanced Science, EarlyView.
This study determines the maximum tolerated dose of lenvatinib in combination with paclitaxel as second‐line therapy for advanced gastric cancer patients. A dynamic network biomarker panel associated with patient prognosis and response to treatment is established.
Chenfei Zhou   +8 more
wiley   +1 more source

Epidemiology and surveillance for hepatocellular carcinoma: New trends.

open access: yesJournal of Hepatology, 2020
A. Singal, P. Lampertico, P. Nahon
semanticscholar   +1 more source

NamiRNA‐Enhancer Network: The Changing Era Challenge and Chance of miRNA

open access: yesAdvanced Science, EarlyView.
MiRNAs (miRNAs) regulate diverse biological processes across species. Unlike canonical miRNA‐mediated gene repression, Nuclear Activating miRNAs (NamiRNAs) can efficiently upregulate gene expression by targeting enhancers. This review systematically summarizes recent advances in NamiRNA research, elucidates the theory of NamiRNA‐Enhancer‐mediated Gene ...
Lu Chen   +13 more
wiley   +1 more source

Patients‐Derived Organoids Sequencing‐based FOXP4 Facilitates Radioresistance by Transcriptionally Modifying GPX4 to Regulate ferroptosis in Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
FOXP4 regulates GPX4 transcription to suppress ferroptosis. In CRC patients, initial biopsies established PDO cultures alongside concurrent chemoradiotherapy. Post‐treatment MRI with mrTRG scoring stratified radioresistant/sensitive cohorts. Parallelly, 8Gy‐irradiated PDOs underwent viability‐based stratification.
Qianping Chen   +17 more
wiley   +1 more source

CACYBP expression predicts prognosis in hepatocellular carcinoma: A meta-analysis and bioinformatics validation. [PDF]

open access: yesMedicine (Baltimore)
Odat RM   +8 more
europepmc   +1 more source

Interfacial Roughness‐Reinforced Magnetic Nanosheet Colloidal Gels for Stable Embolization and Magnetothermal Therapy of Hepatic Tumor

open access: yesAdvanced Science, EarlyView.
A rough‐interface reinforcement strategy is implemented to construct nanosheet‐mica‐based magnetic colloidal hydrogels with enhanced mechanical robustness and injectability. These hydrogels achieve stable vascular embolization and effective magnetothermal performance, offering synergistic therapeutic benefits in hepatic tumor treatment.
Xingyu Liu   +11 more
wiley   +1 more source

PLAUR+ Neutrophils Drive Anti‐PD‐1 Therapy Resistance in Patients with Hepatocellular Carcinoma by Shaping an Immunosuppressive Microenvironment

open access: yesAdvanced Science, EarlyView.
The present study reveals that PLAUR+ neutrophils are enriched in immunotherapy non‐responders and correlate with poor prognosis. PLAUR+ neutrophils dictate immunotherapy resistance in hepatocellular carcinoma by forming an immunosuppressive tumor microenvironment characterized by CD8+ T cell exclusion and macrophage‐dependent immune suppression.
Shaoqing Liu   +11 more
wiley   +1 more source

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