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Comparison of genomic landscapes of large cell neuroendocrine carcinoma, small cell lung carcinoma, and large cell carcinoma [PDF]
Thoracic Cancer, 2019 Background The classification of large cell neuroendocrine carcinoma (LCNEC) has generated considerable debate and has been revised since its recognition as a separate entity. Although it shares clinical features with small cell lung carcinoma (SCLC) and
Zhen Zhou +10 more
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Management of Large Cell Neuroendocrine Carcinoma [PDF]
Frontiers in Oncology, 2021 BackgroundLarge cell neuroendocrine carcinoma (LCNEC) is a rare, aggressive cancer with a dismal prognosis. The majority of cases occur in the lung and the gastrointestinal tract; however, it can occur throughout the body.
Virginia Corbett +3 more
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Molecular Characterization and Prognostication of Large Cell Neuroendocrine Carcinoma and Large Cell Carcinoma [PDF]
Frontiers in Oncology, 2022 PurposeLarge cell neuroendocrine carcinoma (LCNEC) and classic large cell carcinoma (LCC) are two distinct entities with different histological and biological characteristics. However, the mutational profiles and the clinical behavior of the two subtypes
Ying Chen +7 more
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Pulmonary Large Cell Neuroendocrine Carcinoma
Pathology and Oncology Research, 2022 Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a rare subtype of malignant pulmonary tumor. The incidence rate of LCNEC was reported to be 0.3%–3% in lung cancers.
Lan Yang +11 more
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Successful treatment of large-cell neuroendocrine carcinoma of the prostate with pembrolizumab: a case report [PDF]
Journal of Medical Case ReportsBackground Large-cell neuroendocrine carcinoma of the prostate is an extremely rare disease and classified into two subtypes: de novo and treatment-induced large-cell neuroendocrine carcinoma that arises from adenocarcinoma via lineage plasticity in ...
Erika Yamashita +11 more
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Different detection rates of brain metastasis in different pathological types of lung cancer by 18F-FAPI PET/CT [PDF]
BMC CancerBackground The purpose of this study was to evaluate the utility of fluorine-18-fibroblast activation protein inhibitor (18F-FAPI) PET/CT for detecting brain metastasis (BM) in different pathological types of lung cancer using craniocerebral MRI as the ...
Haoqian Li +8 more
doaj +2 more sources
, 2020 Originally large cell carcinoma was defined by the absence of visible glandular or squamoid features. Due to immunohistochemistry introduced into NSCLC diagnosis, this exclusion was extended. Solid carcinomas negative for either TTF1 or p40 without visible glandular or squamoid differentiation are now large cell carcinomas.
Helmut Popper, Bruno Murer
openaire +2 more sources
A Case of Bladder Large Cell Carcinoma with Review of the Literature
Case Reports in Oncology, 2022 Neuroendocrine (NE) tumors of the bladder are infrequent. Among them, large cell NE tumor has been outlined only in case reports and short case series, which describes them as aggressive malignancies with dismal prognosis requiring a multidisciplinary ...
Paolo Lopedote +2 more
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Diagnostic Pathology, 2022 Background Large cell neuroendocrine carcinoma (LCNEC) is a high-grade malignant pulmonary neuroendocrine tumour. The distinction of pulmonary large cell carcinoma (LCC) and LCNEC is based on the presence of neuroendocrine morphology and the expression ...
Zuoyu Liang +10 more
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Pulmonary Combined Large Cell Neuroendocrine Carcinoma
Pathology and Oncology Research, 2022 Pulmonary combined large-cell neuroendocrine carcinoma (CLCNEC) is a rare neuroendocrine tumor pertained to lung large cell neuroendocrine carcinoma (LCNEC) with aggressive behavior and poor prognosis generally.
Meihui Li +9 more
doaj +1 more source