Results 41 to 50 of about 12,476,747 (249)

Acute Presentation of Large Size Clear Cell Ovarian Carcinoma as Double Torsed Ovarian Tumor

Medicina, 2022
We report a 46-year-old patient who presented to the emergency department with complaints of acute abdominal pain, nausea, and vomiting. An abdominal CT scan revealed a large (207 × 155 × 182 mm) thin-walled inhomogeneous tumor connected to the uterus ...
Diana Bužinskienė, Vilius Rudaitis, Karolina Misevičiūtė   +2 more
doaj   +1 more source

MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells [PDF]

, 2011
Background: Esophageal squamous cell carcinoma (ESCC) is often diagnosed at later stages until they are incurable. MicroRNA (miR) is a small, non-coding RNA that negatively regulates gene expression mainly via translational repression.
Yamashita, S., Nakayama Toshiyuki, Matsushima Kayoko, Nagayasu, T., Inoue, N., Hidaka, S., Ohtsuru Akira, Yibin Kang, Hayashi, T., Hajime Isomoto, Masaki Kunizaki, Shigeru Kohno, Mitsutake Norisato, Hidaka Shigekazu, Ohtsuru, A., Takeshi Nagayasu, Naoki Inoue, Nakao Kazuhiko, Mitsutake, N., Nakashima Masahiro, Yamaguchi Naoyuki, Gregory Philip A, Kang Yibin, Matsushima, K., Isomoto Hajime, Ujifuku Kenta, Goodall, G., Kenta Ujifuku, Machida Haruhisa, Nakayama, T., Yamaguchi, N., Korpal Manav, Tomayoshi Hayashi, Kang, Y., Norisato Mitsutake, Philip A Gregory, Naoyuki Yamaguchi, Yamashita Shunichi, Haruhisa Machida, et al., Nagayasu Takeshi, Kohno, S., Machida, H., Nakashima, M., Manav Korpal, Shigekazu Hidaka, Kunizaki, M., Inoue Naoki, Toshiyuki Nakayama, Shunichi Yamashita, Akira Ohtsuru, Goodall Gregory J, Gregory J Goodall, Korpal, M., Kazuhiko Nakao, Isomoto, H., Hayashi Tomayoshi, Gregory, P., Ujifuku, K., Kunizaki Masaki, Kayoko Matsushima, Masahiro Nakashima, Kohno Shigeru   +62 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

The role of the chemokine receptor CXCR4 in oral squamous cell carcinoma metastasis [PDF]

, 2010
PhDOral Squamous Cell Carcinoma (OSCC) is the sixth most common cancer worldwide. The greatest cause of mortality and surgical morbidity is due to the common spread of tumour cells from the primary lesion to the lymph nodes of the neck. This pathway is
Collier, Jonathan Marc
core   +4 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Characterization of POU2F3-expressing large cell neuroendocrine carcinoma of the lung: A comprehensive analysis of morphology, immunohistochemistry, and genomic alterations

Cancer Treatment and Research Communications
Large cell neuroendocrine carcinoma (LCNEC) is a neuroendocrine carcinoma (NEC) of the lung that is characterized by its heterogeneous morphology, diverse immunophenotypes, and complex genomic profiles. Among LCNECs, a subset expressing the transcription
Ryota Matsuoka, Kei Asayama, Tomoki Nakagawa, Yoshihiko Murata, Ayako Suzuki, Yutaka Suzuki, Naohiro Kobayashi, Yukio Sato, Nobuyuki Hizawa, Hiroyoshi Tsubochi, Shunsuke Endo, Koichi Hagiwara, Toshiro Niki, Noriyoshi Fukushima, Kentaro Inamura, Daisuke Matsubara   +15 more
doaj   +1 more source

Large cell neuroendocrine carcinoma of the kidney with cardiac metastasis: a case report

Journal of Medical Case Reports, 2017
Background Primary large cell neuroendocrine carcinoma of the kidney is a rare and generally very aggressive disease. We present a case of a patient with primary large cell neuroendocrine carcinoma of the kidney with cardiac metastasis. Case presentation
Moeka Shimbori, Kimito Osaka, Takashi Kawahara, Ryo Kasahara, Sayuki Kawabata, Kazuhide Makiyama, Keiichi Kondo, Noboru Nakaigawa, Shoji Yamanaka, Masahiro Yao   +9 more
doaj   +1 more source