Results 1 to 10 of about 6,085 (188)

Evaluation of the efficacy of cisplatin-etoposide and the role of thoracic radiotherapy and prophylactic cranial irradiation in LCNEC. [PDF]

ERJ Open Research, 2017
In small-cell lung cancer (SCLC), the role of chemotherapy and radiotherapy is well established. Large-cell neuroendocrine carcinoma (LCNEC) shares several clinicopathological features with SCLC, but its optimal therapy is not defined.
Flavia Longo, Arsela Prelaj, Carla Ferrara   +2 more
exaly   +8 more sources

Treatment of Advanced-Stage Large Cell Neuroendocrine Cancer (LCNEC) of the Lung: A Tale of Two Diseases [PDF]

Frontiers in Oncology, 2021
LCNEC of the lung comprises a small proportion of pulmonary malignancies. Traditionally, they have been classified based on histologic and immunohistochemistry characteristics with features of small cell and non-small cell lung cancer.
Chao H Huang
exaly   +5 more sources

DLL3 expression is a predictive marker of sensitivity to adjuvant chemotherapy for pulmonary LCNEC [PDF]

Thoracic Cancer, 2020
Background The mammalian Notch family ligands delta‐like 3 (DLL3) is reported to be a potential therapeutic target for large cell neuroendocrine carcinomas (LCNEC). The effect of DLL3 expression on LCNEC prognosis has not yet been elucidated.
Megumi Nishikubo, Hiroyuki Ogawa
exaly   +4 more sources

Prevalence of TP-53/Rb-1 Co-Mutation in Large Cell Neuroendocrine Carcinoma [PDF]

Frontiers in Oncology, 2021
IntroductionLarge cell neuroendocrine carcinoma (LCNEC) is a rare and highly aggressive high-grade neuroendocrine neoplasm, which can arise from anywhere in the body.
Hoda Saghaeiannejad Esfahani, Cory M. Vela, Aman Chauhan, Aman Chauhan   +3 more
doaj   +2 more sources

Molecular Characterization and Prognostication of Large Cell Neuroendocrine Carcinoma and Large Cell Carcinoma

Frontiers in Oncology, 2022
PurposeLarge cell neuroendocrine carcinoma (LCNEC) and classic large cell carcinoma (LCC) are two distinct entities with different histological and biological characteristics. However, the mutational profiles and the clinical behavior of the two subtypes
Ying Chen, Xiaoying Cui, Di Wang, Guojie Xia, Minyan Xing, Lei Cheng, Liming Sheng, Xianghui Du   +7 more
doaj   +1 more source

Pulmonary large cell carcinoma with neuroendocrine morphology shows genetic similarity to large cell neuroendocrine carcinoma

Diagnostic Pathology, 2022
Background Large cell neuroendocrine carcinoma (LCNEC) is a high-grade malignant pulmonary neuroendocrine tumour. The distinction of pulmonary large cell carcinoma (LCC) and LCNEC is based on the presence of neuroendocrine morphology and the expression ...
Zuoyu Liang, Weiya Wang, Qianrong Hu, Ping Zhou, Ying Zhang, Yuan Tang, Qian Wu, Yiyun Fu, Xue Li, Yang Shao, Lili Jiang   +10 more
doaj   +1 more source

Comparative Study of Pulmonary Combined Large-Cell Neuroendocrine Carcinoma and Combined Small-Cell Carcinoma in Surgically Resected High-Grade Neuroendocrine Tumors of the Lung

Frontiers in Oncology, 2021
ObjectivesPulmonary large-cell neuroendocrine carcinoma (LCNEC) and small-cell lung cancer (SCLC) are both classified as pure and combined subtypes. Due to the low incidence and difficult diagnosis of combined LCNEC (C-LCNEC) and combined SCLC (C-SCLC ...
Yanan Wang, Fangfei Qian, Ya Chen, Zhengyu Yang, Minjuan Hu, Jun Lu, Yanwei Zhang, Wei Zhang, Lei Cheng, Baohui Han   +9 more
doaj   +1 more source

Response to selpercatinib in a patient with RET fusion-positive pulmonary large-cell neuroendocrine carcinoma: A case report

Frontiers in Oncology, 2023
Large-cell neuroendocrine carcinoma (LCNEC) is a rare subtype of non-small-cell lung cancer associated with a poor prognosis. LCNEC is genetically heterogeneous, and studies have revealed distinct molecular subtypes of LCNEC, which may have therapeutic ...
Aakriti Arora, Jacob Zaemes, Metin Ozdemirli, Chul Kim   +3 more
doaj   +1 more source

Molecular Pathology of Pulmonary Large Cell Neuroendocrine Carcinoma: Novel Concepts and Treatments

Frontiers in Oncology, 2021
Pulmonary large cell neuroendocrine carcinoma (LCNEC) is an aggressive neoplasm with poor prognosis. Histologic diagnosis of LCNEC is not always straightforward.
Masayo Yoshimura, Kurumi Seki, Andrey Bychkov, Andrey Bychkov, Junya Fukuoka, Junya Fukuoka   +5 more
doaj   +1 more source

Outcomes for Surgery in Stage IA Large Cell Lung Neuroendocrine Compared With Other Types of Non-Small Cell Lung Cancer: A Propensity Score Matching Study Based on the Surveillance, Epidemiology, and End Results (SEER) Database

Frontiers in Oncology, 2020
BackgroundPulmonary large cell neuroendocrine cancer (LCNEC) is commonly classified as non-small cell lung cancer (NSCLC). Even for stage I disease, after surgery the survival is always poor, but clinical research on LCNEC is scant and always with ...
Liqing Zou, Liqing Zou, Tiantian Guo, Tiantian Guo, Luxi Ye, Luxi Ye, Yue Zhou, Yue Zhou, Li Chu, Li Chu, Xiao Chu, Xiao Chu, Jianjiao Ni, Jianjiao Ni, Jianjiao Ni, Zhengfei Zhu, Zhengfei Zhu, Zhengfei Zhu, Xi Yang, Xi Yang   +19 more
doaj   +1 more source