Results 11 to 20 of about 6,085 (188)

Selective Tumor‐to‐Tumor Metastasis of the LCNEC Component of a Combined Lung Carcinoma to Clear Cell Renal Cell Carcinoma Despite a Concurrent Meningioma [PDF]

IJU Case Reports, Volume 9, Issue 4, July 2026.
ABSTRACT Introduction Tumor‐to‐tumor metastasis is a rare pathological phenomenon. We report an extremely rare case in which the large cell neuroendocrine carcinoma (LCNEC) component of a combined lung carcinoma selectively metastasized to clear cell renal cell carcinoma (RCC) despite the presence of a concurrent meningioma. Case Presentation A 65‐year‐
Nakanori Fujii, Yoshinobu Hoshii, Koichiro Hiyoshi, Takanori Tokunaga, Kosuke Shimizu, Keita Kobayashi, Hiroshi Hirata, Koji Shiraishi   +7 more
wiley   +3 more sources

Comprehensive analysis of pulmonary Large Cell Neuroendocrine Carcinoma (LCNEC) [PDF]

, 2018
Neuroendocrine tumours in the lungs such as large-cell neuroendocrine carcinoma (LCNEC) are a rare occurrence in the Netherlands. Pathologists, oncologists and lung cancer oncologists are all confronted with various problems regarding the diagnosis and treatment of LCNEC. Firstly, making the diagnosis is difficult due to the lack of standards for small
Derks, Jules Louis
openaire   +8 more sources

DLL3 expression in large cell neuroendocrine carcinoma (LCNEC) and association with molecular subtypes and neuroendocrine profile [PDF]

Lung Cancer, 2019
For stage IV pulmonary large cell neuroendocrine carcinoma (LCNEC), the only therapeutic option is palliative chemotherapy. DLL3 is a new therapeutic target, which seems to be often expressed in SCLC and LCNEC. It has recently been reported that DLL3 mRNA expression is particularly upregulated in the LCNEC subgroup with STK11/KEAP1 and TP53 co ...
B.C.M. Hermans, J.L. Derks, E. Thunnissen, R.J. van Suylen, M.A. den Bakker, H.J.M. Groen, E.F. Smit, R.A. Damhuis, E.C. van den Broek, A. Ruland, E.J.M. Speel, A.M.C. Dingemans   +11 more
openaire   +5 more sources

Clinicopathological characteristics and prognostic factors of pulmonary large cell neuroendocrine carcinoma: A large population‐based analysis

Thoracic Cancer, 2019
Background The study was conducted to compare the clinicopathological characteristics, survival outcomes, and metastatic patterns between pulmonary large cell neuroendocrine carcinoma (LCNEC) and other non‐small cell lung cancer (ONSCLC), and to identify
Qiao Yang, Zihan Xu, Xiewan Chen, Linpeng Zheng, Yongxin Yu, Xianlan Zhao, Mingjing Chen, Bangyu Luo, Jianmin Wang, Jianguo Sun   +9 more
doaj   +2 more sources

Characterization of POU2F3-expressing large cell neuroendocrine carcinoma of the lung: A comprehensive analysis of morphology, immunohistochemistry, and genomic alterations

Cancer Treatment and Research Communications
Large cell neuroendocrine carcinoma (LCNEC) is a neuroendocrine carcinoma (NEC) of the lung that is characterized by its heterogeneous morphology, diverse immunophenotypes, and complex genomic profiles. Among LCNECs, a subset expressing the transcription
Ryota Matsuoka, Kei Asayama, Tomoki Nakagawa, Yoshihiko Murata, Ayako Suzuki, Yutaka Suzuki, Naohiro Kobayashi, Yukio Sato, Nobuyuki Hizawa, Hiroyoshi Tsubochi, Shunsuke Endo, Koichi Hagiwara, Toshiro Niki, Noriyoshi Fukushima, Kentaro Inamura, Daisuke Matsubara   +15 more
doaj   +3 more sources

Comparison of genomic landscapes of large cell neuroendocrine carcinoma, small cell lung carcinoma, and large cell carcinoma

Thoracic Cancer, 2019
Background The classification of large cell neuroendocrine carcinoma (LCNEC) has generated considerable debate and has been revised since its recognition as a separate entity. Although it shares clinical features with small cell lung carcinoma (SCLC) and
Zhen Zhou, Lei Zhu, Xiaomin Niu, Shengping Shen, Yi Zhao, Jie Zhang, Junyi Ye, Han Han‐Zhang, Junjun Liu, Chenglin Liu, Shun Lu   +10 more
doaj   +2 more sources

Primary Large Cell Neuroendocrine Carcinoma of the Bladder Successfully Treated With Radical Cystectomy Alone: A Case Report [PDF]

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Primary large‐cell neuroendocrine carcinoma of the bladder is highly invasive and has a poor prognosis. However, early curative treatment may lead to a good prognosis.
Shun Aoki, Takashi Kawahara, Yuri Nishino, Hideki Tsukada, Takayuki Hirano, Genta Iwamoto, Shusei Fusayasu, Jun‐ichi Teranishi, Kazuhide Makiyama, Hiroyuki Hayashi, Hiroji Uemura, Masatoshi Moriyama, Junichi Ohta   +12 more
wiley   +2 more sources

Long lasting octreotide LAR therapy in large cell neuroendocrine carcinoma (LCNEC) of the lung [PDF]

Clinical Management Issues, 2015
In this article we report a case of a patient with large cell neuroendocrine carcinoma (LCNEC) of the lung. Patients with LCNEC usually have poor prognosis and the benefit of adjuvant chemotherapy for these patients has not been fully established. This case suggests that octreotide LAR, a somatostatine analogue (SSA), can be useful in the treatment of ...
Alfredo Butera, Butera, Alfredo
openaire   +4 more sources

Incidence, survival comparison, and novel prognostic evaluation approaches for stage iii-iv pulmonary large cell neuroendocrine carcinoma and small cell lung cancer

BMC Cancer, 2023
Background Pulmonary large cell neuroendocrine carcinoma (LCNEC) and small cell lung cancer (SCLC) are two types of high-grade neuroendocrine carcinomas of the lung with poor prognosis.
Liling Huang, Yu Feng, Tongji Xie, Haohua Zhu, Le Tang, Yuankai Shi   +5 more
doaj   +2 more sources

Ambient air pollution and survival in SCLC/LCNEC: Analysis of a single centre retrospective cohort

European Journal of Cancer
Small cell lung cancer (SCLC) and large cell neuroendocrine carcinoma of the lung (LCNEC) are the deadliest forms of lung cancer with dismal prognosis. Recent evidence suggests that, beyond cigarette smoke, air pollution can have a role in the pathogenesis of non-small cell lung cancer (NSCLC) and is associated with poorer survival.
Ammoni, Luca Carlofrancesco, Cortesi, Valentina, Borghetti, Paolo, Baggi, Alice, Vultaggio, Camilla, Amoroso, Vito, Facheris, Giorgio, Facchetti, Mattia, Bianchi, Susanna, Lagana', Marta, Cosentini, Deborah, Nonnis, Daniela, Magrini, Stefano Maria, Berruti, Alfredo, Grisanti, Salvatore   +14 more
openaire   +4 more sources